scholarly journals Gold nanorods as photothermal agents and autofluorescence enhancer to track cell death during plasmonic photothermal therapy

2015 ◽  
Author(s):  
Ravi Kumar Kannadorai ◽  
Geraldine Giap Ying Chiew ◽  
Kathy Qian Luo ◽  
Quan Liu
Keyword(s):  
Cell Death ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Plasmonic Photothermal Therapy

scholarly journals A Novel Fast Photothermal Therapy Using Hot Spots of Gold Nanorods for Malignant Melanoma Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 880 ◽  
Author(s):  
Yanhua Yao ◽  
Nannan Zhang ◽  
Xiao Liu ◽  
Qiaofeng Dai ◽  
Haiying Liu ◽  
...  
Keyword(s):  
Cell Death ◽  
Malignant Melanoma ◽  
Gold Nanorods ◽  
Plasmon Resonance ◽  
Photothermal Therapy ◽  
Treatment Time ◽  
High Energy ◽  
Melanoma Cells ◽  
Photothermal Effect ◽  
A375 Cells

In this paper, the plasmon resonance effects of gold nanorods was used to achieve rapid photothermal therapy for malignant melanoma cells (A375 cells). After incubation with A375 cells for 24 h, gold nanorods were taken up by the cells and gold nanorod clusters were formed naturally in the organelles of A375 cells. After analyzing the angle and space between the nanorods in clusters, a series of numerical simulations were performed and the results show that the plasmon resonance coupling between the gold nanorods can lead to a field enhancement of up to 60 times. Such high energy localization causes the temperature around the nanorods to rise rapidly and induce cell death. In this treatment, a laser as low as 9.3 mW was used to irradiate a single cell for 20 s and the cell died two h later. The cell death time can also be controlled by changing the power of laser which is focused on the cells. The advantage of this therapy is low laser treatment power, short treatment time, and small treatment range. As a result, the damage of the normal tissue by the photothermal effect can be greatly avoided.

Plasmonic Photothermal Therapy with Gold Nanorods/Reduced Graphene Oxide Core/Shell Nanocomposites

2016 ◽  
pp. 3287-3294
Author(s):  
Kostiantyn Turcheniuk ◽  
Charles-Henri Hage ◽  
Jolanda Spadavecchia ◽  
Laurent Heliot ◽  
Rabah Boukherroub ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Core Shell ◽  
Reduced Graphene ◽  
Plasmonic Photothermal Therapy

scholarly journals Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice

2017 ◽  
Vol 114 (15) ◽  
pp. E3110-E3118 ◽  
Author(s):  
Moustafa R. K. Ali ◽  
Mohammad Aminur Rahman ◽  
Yue Wu ◽  
Tiegang Han ◽  
Xianghong Peng ◽  
...  
Keyword(s):  
Cell Death ◽  
Mechanism Of Action ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Mouse Tumor ◽  
Maximal Induction

Gold nanorods (AuNRs)-assisted plasmonic photothermal therapy (AuNRs-PPTT) is a promising strategy for combating cancer in which AuNRs absorb near-infrared light and convert it into heat, causing cell death mainly by apoptosis and/or necrosis. Developing a valid PPTT that induces cancer cell apoptosis and avoids necrosis in vivo and exploring its molecular mechanism of action is of great importance. Furthermore, assessment of the long-term fate of the AuNRs after treatment is critical for clinical use. We first optimized the size, surface modification [rifampicin (RF) conjugation], and concentration (2.5 nM) of AuNRs and the PPTT laser power (2 W/cm2) to achieve maximal induction of apoptosis. Second, we studied the potential mechanism of action of AuNRs-PPTT using quantitative proteomic analysis in mouse tumor tissues. Several death pathways were identified, mainly involving apoptosis and cell death by releasing neutrophil extracellular traps (NETs) (NETosis), which were more obvious upon PPTT using RF-conjugated AuNRs (AuNRs@RF) than with polyethylene glycol thiol-conjugated AuNRs. Cytochrome c and p53-related apoptosis mechanisms were identified as contributing to the enhanced effect of PPTT with AuNRs@RF. Furthermore, Pin1 and IL18-related signaling contributed to the observed perturbation of the NETosis pathway by PPTT with AuNRs@RF. Third, we report a 15-month toxicity study that showed no long-term toxicity of AuNRs in vivo. Together, these data demonstrate that our AuNRs-PPTT platform is effective and safe for cancer therapy in mouse models. These findings provide a strong framework for the translation of PPTT to the clinic.

The effects of folate-conjugated gold nanorods in combination with plasmonic photothermal therapy on mouth epidermal carcinoma cells

2013 ◽  
Vol 29 (3) ◽  
pp. 939-948 ◽  
Author(s):  
Alireza Mehdizadeh ◽  
Sajjad Pandesh ◽  
Ali Shakeri-Zadeh ◽  
Seyed Kamran Kamrava ◽  
Mojtaba Habib-Agahi ◽  
...  
Keyword(s):  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Carcinoma Cells ◽  
Epidermal Carcinoma ◽  
Plasmonic Photothermal Therapy

Plasmonic Photothermal Therapy of Transplanted Tumors in Rats at Multiple Intravenous Injection of Gold Nanorods

2016 ◽  
Vol 7 (1) ◽  
pp. 216-221 ◽  
Author(s):  
A. B. Bucharskaya ◽  
G. N. Maslyakova ◽  
N. I. Dikht ◽  
N. A. Navolokin ◽  
G. S. Terentyuk ◽  
...  
Keyword(s):  
Intravenous Injection ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Transplanted Tumors ◽  
Plasmonic Photothermal Therapy
Sign in / Sign up

Export Citation Format

Share Document