Quantitative phase imaging-based refractive index determination of living cells using incorporated microspheres as reference

2011 ◽  
Author(s):  
Björn Kemper ◽  
Sabine Przibilla ◽  
Angelika Vollmer ◽  
Steffi Ketelhut ◽  
Gert von Bally
Keyword(s):  
Refractive Index ◽  
Living Cells ◽  
Phase Imaging ◽  
Quantitative Phase Imaging ◽  
Quantitative Phase

scholarly journals Accurate evaluation of size and refractive index for spherical objects in quantitative phase imaging

2018 ◽  
Vol 26 (8) ◽  
pp. 10729 ◽  
Author(s):  
Paul Müller ◽  
Mirjam Schürmann ◽  
Salvatore Girardo ◽  
Gheorghe Cojoc ◽  
Jochen Guck
Keyword(s):  
Refractive Index ◽  
Phase Imaging ◽  
Quantitative Phase Imaging ◽  
Accurate Evaluation ◽  
Quantitative Phase

Multi-modal and photothermal quantitative phase imaging of living cells with nanoparticles in a combined setup

2017 ◽  
Author(s):  
Björn Kemper ◽  
Nir A. Turko ◽  
Michael Isbach ◽  
Steffi Ketelhut ◽  
Burkhard Greve ◽  
...  
Keyword(s):  
Living Cells ◽  
Phase Imaging ◽  
Quantitative Phase Imaging ◽  
Quantitative Phase

scholarly journals Tissue disorder strength measured by quantitative phase imaging as intrinsic cancer marker

2017 ◽  
Author(s):  
Masanori Takabayashi ◽  
Hassaan Majeed ◽  
Andre Kajdacsy-Balla ◽  
Gabriel Popescu
Keyword(s):  
Refractive Index ◽  
Imaging System ◽  
Tissue Sample ◽  
Optical Path Length ◽  
Phase Imaging ◽  
Disorder Strength ◽  
Quantitative Phase Imaging ◽  
Quantitative Phase ◽  
Path Length Difference ◽  
Malignant Breast

AbstractTissue refractive index provides important information about morphology at the nanoscale. Since the malignant transformation involves both intra- and inter-cellular changes in the refractive index map, the tissue disorder measurement can be used to extract important diagnosis information. Quantitative phase imaging (QPI) provides a practical means of extracting this information as it maps the optical path-length difference (OPD) across a tissue sample with sub-wavelength sensitivity. In this work, we employ QPI to compare the tissue disorder strength between benign and malignant breast tissue histology samples. Our results show that disease progression is marked by a significant increase in the disorder strength. Since our imaging system can be added as an upgrading module to an existing microscope, we anticipate that it can be integrated easily in the pathology work flow.

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