Combining Angle-Resolved Raman Scattering and Confocal Raman Microscopy for Rationally Designing Two-Dimensional Metallic Arrays as High Performing SERS Substrates

2011 ◽  
Author(s):  
Z.L. Cao ◽  
C.Y. Chan ◽  
L. Zhang ◽  
H.C. Ong
Keyword(s):  
Raman Scattering ◽  
Raman Microscopy ◽  
Two Dimensional ◽  
Confocal Raman Microscopy ◽  
High Performing ◽  
Sers Substrates ◽  
Confocal Raman ◽  
Metallic Arrays

Label-free tracking of nanosized graphene oxide cellular uptake by confocal Raman microscopy

The Analyst ◽  
2018 ◽  
Vol 143 (15) ◽  
pp. 3686-3692 ◽  
Author(s):  
Marianna Eliášová Sohová ◽  
Michal Bodík ◽  
Peter Siffalovic ◽  
Nikola Bugárová ◽  
Martina Labudová ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Cellular Uptake ◽  
Cancer Diagnostics ◽  
Raman Microscopy ◽  
Two Dimensional ◽  
Confocal Raman Microscopy ◽  
Label Free ◽  
Confocal Raman ◽  
Diagnostics And Therapy

Graphene oxide (GO), a partially oxidized two-dimensional allotrope of carbon, is an attractive nanocarrier for cancer diagnostics and therapy.

Optimizing Detection Sensitivity on Surface-Enhanced Raman Scattering of Transition-Metal Electrodes with Confocal Raman Microscopy

2003 ◽  
Vol 57 (4) ◽  
pp. 419-427 ◽  
Author(s):  
Bin Ren ◽  
Xu-Feng Lin ◽  
Yu-Xiong Jiang ◽  
Pei-Gen Cao ◽  
Yong Xie ◽  
...  
Keyword(s):  
Transition Metal ◽  
Raman Scattering ◽  
Raman Microscopy ◽  
Detection Sensitivity ◽  
Confocal Raman Microscopy ◽  
Metal Electrodes ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Confocal Raman

Some points on how to improve the detection sensitivity of confocal Raman microscopy for the study of surface-enhanced Raman scattering (SERS) of transition-metal electrodes are discussed, including the careful design of the spectroelectrochemical cell, proper selection of the thickness of the solution layer, the binning of charge-coupled device (CCD) pixels, and appropriate setting of the notch filter. Various roughening methods for the Pt, Rh, Fe, Co, and Ni electrode surfaces have been introduced in order to obtain SERS-active surfaces. It has been shown that the appropriate roughening procedure and the optimizing performance of the confocal Raman microscope are the two most important factors to directly generate and observe SERS on net transition-metal electrodes.

Single Layer Graphene for Estimation of Axial Spatial Resolution in Confocal Raman Microscopy Depth Profiling

2018 ◽  
Vol 91 (1) ◽  
pp. 1049-1055 ◽  
Author(s):  
Carol Korzeniewski ◽  
Jay P. Kitt ◽  
Saheed Bukola ◽  
Stephen E. Creager ◽  
Shelley D. Minteer ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Depth Profiling ◽  
Single Layer ◽  
Raman Microscopy ◽  
Single Layer Graphene ◽  
Confocal Raman Microscopy ◽  
Layer Graphene ◽  
Confocal Raman

scholarly journals Real-Time Drug Release Imaging From Nanocomposite Drug and Polymer Coatings

2008 ◽  
Vol 2 (2) ◽  
Author(s):  
Jinping Dong ◽  
Greg Haugstad ◽  
Chris Frethem ◽  
John Foley ◽  
Bob Hoerr ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Polymer Coatings ◽  
Raman Microscopy ◽  
Prolonged Release ◽  
Confocal Raman Microscopy ◽  
Release Process ◽  
Force Microscopy ◽  
Confocal Raman ◽  
Model Drug

The ElectroNanospray process (Nanocopoeia, Inc) transforms drugs and polymers into many nanoscale material states including powders, liquids, encapsulated particles, and coatings. This allows application of polymers and drugs to the surface of medical devices such as coronary stents in a single-stage process. A model drug delivery system consisting of a polymer matrix (arborescent polyisobutylene-polystyrene, or arbIBS) and either dexamethasone or sirolimus was studied by various characterization techniques. Modification of ElectroNanospray process parameters resulted in surface coatings with rich morphologies that are revealed by SEM, Atomic Force Microscopy (AFM) and Confocal Raman Microscopy were employed to monitor the drug release process in situ, through which the mechanism of the drug-eluting process may be proposed. A Confocal Raman microscope fitted with underwater objective was used to image arbIBS∕drug films incubated in phosphate-buffered saline over 12h and at various film depths. Drug migrated from more concentrated areas into the surrounding polymer and toward the surface, beginning as early as 5min after placing the sample in buffer and continuing throughout the 12h period. High drug levels remained in the more concentrated areas at the end of incubation, suggesting the potential for prolonged release. SEM and AFM images taken from samples post incubation showed the appearance of nanoscale pores ∼100nm in diameter in areas corresponding in size and distribution to the Confocal Raman planar image areas of increased drug concentration. Confocal Raman microscopy offers a powerful new technique for demonstrating real-time drug release from therapeutic medical device coatings.

scholarly journals Label-Free Live-Cell Imaging with Confocal Raman Microscopy

2012 ◽  
Vol 102 (2) ◽  
pp. 360-368 ◽  
Author(s):  
Katharina Klein ◽  
Alexander M. Gigler ◽  
Thomas Aschenbrenner ◽  
Roberto Monetti ◽  
Wolfram Bunk ◽  
...  
Keyword(s):  
Live Cell Imaging ◽  
Cell Imaging ◽  
Raman Microscopy ◽  
Live Cell ◽  
Confocal Raman Microscopy ◽  
Label Free ◽  
Confocal Raman
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