Optical Control of Neural Activity by Waveguide Delivery in Genetically Targeted Brain Tissue

2009 ◽  
Author(s):  
Jiayi Zhang ◽  
Farah Laiwalla ◽  
Jennifer Kim ◽  
Rick Van Wagenen ◽  
Yoon-Kyu Song ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Neural Activity ◽  
Optical Control

scholarly journals Microbial Opsins: A Family of Single-Component Tools for Optical Control of Neural Activity

2011 ◽  
Vol 2011 (3) ◽  
pp. top102 ◽  
Author(s):  
Ofer Yizhar ◽  
Lief Fenno ◽  
Feng Zhang ◽  
Peter Hegemann ◽  
Karl Diesseroth
Keyword(s):  
Neural Activity ◽  
Single Component ◽  
Optical Control

Optical Control of Neural Activity with Amorphous Silicon Light Addressable Electrodes

2010 ◽  
Author(s):  
H. Y. Hsu ◽  
H. Lee ◽  
A. Jamshidi ◽  
J. Valley ◽  
S. N. Pei ◽  
...  
Keyword(s):  
Amorphous Silicon ◽  
Neural Activity ◽  
Optical Control

scholarly journals Integrated device for optical stimulation and spatiotemporal electrical recording of neural activity in light-sensitized brain tissue

2009 ◽  
Vol 6 (5) ◽  
pp. 055007 ◽  
Author(s):  
Jiayi Zhang ◽  
Farah Laiwalla ◽  
Jennifer A Kim ◽  
Hayato Urabe ◽  
Rick Van Wagenen ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Neural Activity ◽  
Optical Stimulation ◽  
Electrical Recording ◽  
Integrated Device

scholarly journals The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX) Version 2.0: Modelling in vitro electrical stimulation of brain tissue

2019 ◽  
Vol 4 ◽  
pp. 20
Author(s):  
Christopher Thornton ◽  
Frances Hutchings ◽  
Marcus Kaiser
Keyword(s):  
Electrical Stimulation ◽  
Brain Tissue ◽  
Neural Activity ◽  
Long Term Potentiation ◽  
Neuronal Circuits ◽  
Electrode Recording ◽  
Extracellular Potentials ◽  
Stimulation Of ◽  
Virtual Electrode

Neuronal circuits can be modelled in detail allowing us to predict the effects of stimulation on individual neurons. Electrical stimulation of neuronal circuits in vitro and in vivo excites a range of neurons within the tissue and measurements of neural activity, e.g the local field potential (LFP), are again an aggregate of a large pool of cells. The previous version of our Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX) allowed for the simulation of the LFP generated by a patch of brain tissue. Here, we extend VERTEX to simulate the effect of electrical stimulation through a focal electric field. We observe both direct changes in neural activity and changes in synaptic plasticity. Testing our software in a model of a rat neocortical slice, we determine the currents contributing to the LFP, the effects of paired pulse stimulation to induce short term plasticity (STP), and the effect of theta burst stimulation (TBS) to induce long term potentiation (LTP).

Millisecond-timescale, genetically targeted optical control of neural activity

2005 ◽  
Vol 8 (9) ◽  
pp. 1263-1268 ◽  
Author(s):  
Edward S Boyden ◽  
Feng Zhang ◽  
Ernst Bamberg ◽  
Georg Nagel ◽  
Karl Deisseroth
Keyword(s):  
Neural Activity ◽  
Optical Control
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