Diffuse Optical Tomography for Noninvasive Functional Brain Imaging in Awake Behaving Humans

2018 ◽  
Author(s):  
Xianjin Dai ◽  
hao yang ◽  
huabei jiang
Keyword(s):  
Brain Imaging ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Functional Brain Imaging ◽  
Functional Brain

scholarly journals Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers

Sensors ◽  
2020 ◽  
Vol 20 (10) ◽  
pp. 2815
Author(s):  
David Orive-Miguel ◽  
Laura Di Sieno ◽  
Anurag Behera ◽  
Edoardo Ferocino ◽  
Davide Contini ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Near Infrared ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Brain Activation ◽  
Functional Brain Imaging ◽  
Dual Wavelength ◽  
Silicon Photomultipliers ◽  
Functional Brain ◽  
Tomography System

Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength (670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution.

Optical Self-guiding Diffuse Optical Tomography towards Near-infrared Functional Brain Imaging

2016 ◽  
Vol 45 (11) ◽  
pp. 1117001
Author(s):  
赵会娟 ZHAO Hui-juan ◽  
戚彩霞 QI Cai-xia ◽  
刘明 LIU Ming ◽  
秦转萍 QIN Zhuan-ping ◽  
张耀 ZHANG Yao ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Near Infrared ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Functional Brain Imaging ◽  
Functional Brain

Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography

2015 ◽  
Author(s):  
Laura A. Dempsey ◽  
Robert J. Cooper ◽  
Samuel Powell ◽  
Andrea Edwards ◽  
Chuen-Wai Lee ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Functional Brain Imaging ◽  
Time Resolved ◽  
Functional Brain

Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography

2015 ◽  
Author(s):  
Laura A. Dempsey ◽  
Robert J. Cooper ◽  
Samuel Powell ◽  
Andrea Edwards ◽  
Chuen-Wai Lee ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Functional Brain Imaging ◽  
Time Resolved ◽  
Functional Brain

scholarly journals Non-contact acquisition of brain function using a time-extracted compact camera

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Takamasa Ando ◽  
Tatsuya Nakamura ◽  
Toshiya Fujii ◽  
Teruhiro Shiono ◽  
Tasuku Nakamura ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Imaging Techniques ◽  
Brain Activity ◽  
Optical Tomography ◽  
Human Head ◽  
Image Sensor ◽  
Functional Brain Imaging ◽  
High Density ◽  
Brain Images ◽  
Functional Brain

AbstractA revolution in functional brain imaging techniques is in progress in the field of neurosciences. Optical imaging techniques, such as high-density diffuse optical tomography (HD-DOT), in which source-detector pairs of probes are placed on subjects’ heads, provide better portability than conventional functional magnetic resonance imaging (fMRI) equipment. However, these techniques remain costly and can only acquire images at up to a few measurements per square centimetre, even when multiple detector probes are employed. In this study, we demonstrate functional brain imaging using a compact and affordable setup that employs nanosecond-order pulsed ordinary laser diodes and a time-extracted image sensor with superimposition capture of scattered components. Our technique can simply and easily attain a high density of measurement points without requiring probes to be attached, and can directly capture two-dimensional functional brain images. We have demonstrated brain activity imaging using a phantom that mimics the optical properties of an adult human head, and with a human subject, have measured cognitive brain activation while the subject is solving simple arithmetical tasks.

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