Interferometric Near-Infrared Spectroscopy (iNIRS) Monitors Optical Properties and Blood Flow In Vivo

2017 ◽  
Author(s):  
Vivek J. Srinivasan ◽  
Oybek Kholiqov ◽  
Dawid Borycki
Keyword(s):  
Blood Flow ◽  
Optical Properties ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared

Influence of Blood Glucose Level on the Scattering Coefficient of the Skin in Near-Infrared Spectroscopy

2011 ◽  
Author(s):  
Sachiko Kessoku ◽  
Katsuhiko Maruo ◽  
Shinpei Okawa ◽  
Kazuto Masamoto ◽  
Yukio Yamada
Keyword(s):  
Optical Properties ◽  
Infrared Spectroscopy ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Monitoring Methods ◽  
Absorbance Spectra

Various non-invasive glucose monitoring methods using near-infrared spectroscopy have been investigated although no method has been successful so far. Our previous study has proposed a new promising method utilizing numerically generated absorbance spectra instead of the experimentally acquired absorbance spectra. The method suggests that the correct estimation of the optical properties is very important for numerically generating the absorbance spectra. The purpose of this study is to measure the change in the optical properties of the skin with the change in the blood glucose level in vivo. By measuring the reflectances of light incident on the skin surface at two distances from the incident point, the optical properties of the skin can be estimated. The estimation is a kind of the inverse problem based on the simulation of light propagation in the skin. Phantom experiments have verified the method and in vivo experiments are to be performed.

Skin Blood Flow Affects In Vivo Near-Infrared Spectroscopy Measurements in Human Skeletal Muscle

2005 ◽  
Vol 55 (4) ◽  
pp. 241-244 ◽  
Author(s):  
Michael J. Buono ◽  
Paul W. Miller ◽  
Clifford Hom ◽  
Robert S. Pozos ◽  
Fred W. Kolkhorst
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Skin Blood Flow ◽  
Human Skeletal Muscle ◽  
Near Infrared

In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy

2005 ◽  
Vol 10 (2) ◽  
pp. 024028 ◽  
Author(s):  
Jun Zhao ◽  
Hai Shu Ding ◽  
Xin Lin Hou ◽  
Cong Le Zhou ◽  
Britton Chance
Keyword(s):  
Optical Properties ◽  
Infrared Spectroscopy ◽  
Frequency Domain ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Infant Brain

scholarly journals Non-Invasive Measurement Of Tissue Chromophore Concentrations And Cerebral Blood Flow Using Broad-Band Continuous Wave Near Infrared Spectroscopy

2021 ◽  
Author(s):  
Hadi Zabihi-Yeganeh
Keyword(s):  
Blood Flow ◽  
Optical Properties ◽  
Cerebral Blood Flow ◽  
Infrared Spectroscopy ◽  
Indocyanine Green ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Continuous Wave ◽  
Broad Band ◽  
Optical Properties Of Tissue

We present a broad-band, continuous wave spectral approach to quantify the baseline optical properties of tissue, in particular the absolute absorption and scattering properties and changes in the concentrations of chromophores, which can assist to quantify the regional blood flow from dynamic contrast-enhanced near-infrared spectroscopy data. Experiments were conducted on phantoms and piglets. The baseline optical properties of tissue were determined by performing a multi-parameter wavelength-dependent differential data fit of the near infrared reflectance spectrum between 680 nm and 970 nm of a photon diffusion equation solution for a semi-infinite homogeneous medium. These baseline optical properties of the piglet head tissue were used to quantify the temporal dynamics of the concentration of the intravenously administered contrast agent Indocyanine Green in the piglet brain. The temporal traces of the Indocyanine Green concentration measured by our method were used to estimate the cerebral blood flow using a bolus tracking technique.

scholarly journals In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy

2017 ◽  
Vol 4 (04) ◽  
pp. 1 ◽  
Author(s):  
Lorenzo Spinelli ◽  
Lucia Zucchelli ◽  
Davide Contini ◽  
Matteo Caffini ◽  
Jacques Mehler ◽  
...  
Keyword(s):  
Optical Properties ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Time Domain ◽  
Near Infrared ◽  
Hemodynamic Parameters

scholarly journals Non-Invasive Measurement Of Tissue Chromophore Concentrations And Cerebral Blood Flow Using Broad-Band Continuous Wave Near Infrared Spectroscopy

2021 ◽  
Author(s):  
Hadi Zabihi-Yeganeh
Keyword(s):  
Blood Flow ◽  
Optical Properties ◽  
Cerebral Blood Flow ◽  
Infrared Spectroscopy ◽  
Indocyanine Green ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Continuous Wave ◽  
Broad Band ◽  
Optical Properties Of Tissue

We present a broad-band, continuous wave spectral approach to quantify the baseline optical properties of tissue, in particular the absolute absorption and scattering properties and changes in the concentrations of chromophores, which can assist to quantify the regional blood flow from dynamic contrast-enhanced near-infrared spectroscopy data. Experiments were conducted on phantoms and piglets. The baseline optical properties of tissue were determined by performing a multi-parameter wavelength-dependent differential data fit of the near infrared reflectance spectrum between 680 nm and 970 nm of a photon diffusion equation solution for a semi-infinite homogeneous medium. These baseline optical properties of the piglet head tissue were used to quantify the temporal dynamics of the concentration of the intravenously administered contrast agent Indocyanine Green in the piglet brain. The temporal traces of the Indocyanine Green concentration measured by our method were used to estimate the cerebral blood flow using a bolus tracking technique.

scholarly journals A Versatile Setup for Time-Resolved Functional Near Infrared Spectroscopy Based on Fast-Gated Single-Photon Avalanche Diode and on Four-Wave Mixing Laser

2019 ◽  
Vol 9 (11) ◽  
pp. 2366 ◽  
Author(s):  
Laura Di Sieno ◽  
Alberto Dalla Mora ◽  
Alessandro Torricelli ◽  
Lorenzo Spinelli ◽  
Rebecca Re ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Single Photon ◽  
Wave Mixing ◽  
Functional Near Infrared Spectroscopy ◽  
Time Resolved ◽  
Diffusive Medium ◽  
Spectroscopy System

In this paper, a time-domain fast gated near-infrared spectroscopy system is presented. The system is composed of a fiber-based laser providing two pulsed sources and two fast gated detectors. The system is characterized on phantoms and was tested in vivo, showing how the gating approach can improve the contrast and contrast-to-noise-ratio for detection of absorption perturbation inside a diffusive medium, regardless of source-detector separation.

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