scholarly journals Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

2018 ◽  
Vol 9 (12) ◽  
pp. 6331 ◽  
Author(s):  
Wes M. Allen ◽  
Ken Y. Foo ◽  
Renate Zilkens ◽  
Kelsey M. Kennedy ◽  
Qi Fang ◽  
...  
Keyword(s):  
Breast Conserving Surgery ◽  
Optical Coherence ◽  
Tumor Margins

Microscale imaging of breast tumor margins using optical coherence elastography

SPIE Newsroom ◽  
2017 ◽  
Author(s):  
Lixin Chin ◽  
Wes M. Allen ◽  
Bruce Latham ◽  
Christobel M. Saunders ◽  
Brendan F. Kennedy
Keyword(s):  
Breast Tumor ◽  
Optical Coherence ◽  
Tumor Margins

scholarly journals Intraoperative 18F-FDG Flexible Autoradiography for Tumour Margin Assessment in Breast-conserving Surgery – A First-in-Human Multicentre Feasibility Study

2020 ◽  
Author(s):  
Patriek A.G.T. Jurrius ◽  
Maarten R Grootendorst ◽  
Marika Krotewicz ◽  
Massimiliano Cariati ◽  
Ashutosh Kothari ◽  
...  
Keyword(s):  
Imaging System ◽  
Tumor Resection ◽  
Surgical Excision ◽  
Breast Conserving Surgery ◽  
Margin Assessment ◽  
Tumor Margins ◽  
Theatre Staff ◽  
Increased Sensitivity ◽  
Multi Center Study ◽  
Intraoperative Margin Assessment

Abstract IntroductionIn women undergoing breast-conserving surgery (BCS) 20-25% require a re-operation as a result of incomplete tumor resection. An intra-operative technique to assess tumor margins accurately would be a major advantage. A novel method for intraoperative margin assessment was developed by applying a thin flexible scintillating film to specimens - flexible autoradiography (FAR). A single arm, multi-center study was conducted to evaluate the feasibility of intraoperative 18F-FDG FAR for the assessment of tumor margins in BCS.MethodsEighty-eight patients with invasive breast cancer undergoing BCS received ≤300 MBq of 18F-FDG 60-180 minutes pre-operatively. Following surgical excision, intraoperative FAR was performed using the LightPath® Imaging System. The first 16 patients were familiarization patients, the remaining 72 patients were entered into the main study. FAR images were analyzed post-operatively by three independent readers. Areas of increased signal intensity were marked, mean decay corrected radiances and tumor-to-tissue background (TBR) determined, agreement between histopathological margin status and FAR assessed and radiation dose to operating theatre staff measured. Subgroup analyses were performed for various covariates, with thresholds set based on ROC curves.ResultsData analysis was performed on 66 patients. Intraoperative margin assessment using FAR was completed on 385 margins with 46.2% sensitivity, 81.7% specificity, 8.1% PPV, 97.7% NPV and an overall accuracy of 80.5%, detecting both invasive carcinoma and DCIS. A subgroup analysis based on 18F-FDG activity present at time of imaging revealed an increased sensitivity (71.4%), PPV (9.3%) and NPV (98.4%) in the high-activity cohort with mean tumor radiance and TBR of 126.7 ± 45.7 photons/s/cm2/sr/MBq and 2.1 ± 0.5, respectively. Staff radiation exposure was low (38.2 ± 38.1 µSv).Conclusion18F-FDG FAR is a feasible and safe technique for intraoperative tumor margin assessment. Further improvements in diagnostic performance require optimizing the method for scintillator positioning and/or the use of targeted radiopharmaceuticals.Trial registrationClinicalTrials.gov- Identifier: NCT02666079- Date of registration: 28 January 2016- URL: https://clinicaltrials.gov/ct2/show/NCT02666079ISRCTN registry- Reference: ISRCTN17778965- Date of registration: 11 February 2016- URL: http://www.isrctn.com/ISRCTN17778965

scholarly journals Multispectral Optoacoustic Tomography in Assessment of Breast Tumor Margins During Breast-Conserving Surgery: A First-in-human Case Study

2018 ◽  
Vol 18 (6) ◽  
pp. e1247-e1250 ◽  
Author(s):  
Yonggeng Goh ◽  
Ghayathri Balasundaram ◽  
Mohesh Moothanchery ◽  
Amalina Attia ◽  
Xiuting Li ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Breast Conserving Surgery ◽  
Human Case ◽  
Optoacoustic Tomography ◽  
Tumor Margins

Detection of brain tumor margins using optical coherence tomography

2018 ◽  
Author(s):  
Ronald Miguel Juarez Chambi ◽  
Carmen Kut ◽  
Jesus Rico-Jimenez ◽  
Daniel U. Campos-Delgado ◽  
Alfredo Quinones-Hinojosa ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Brain Tumor ◽  
Optical Coherence ◽  
Tumor Margins

scholarly journals Intraoperative Evaluation of Breast Tumor Margins with Optical Coherence Tomography

2009 ◽  
Vol 69 (22) ◽  
pp. 8790-8796 ◽  
Author(s):  
F. T. Nguyen ◽  
A. M. Zysk ◽  
E. J. Chaney ◽  
J. G. Kotynek ◽  
U. J. Oliphant ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Breast Tumor ◽  
Optical Coherence ◽  
Tumor Margins ◽  
Intraoperative Evaluation

Detection of brain tumor margins using optical coherence tomography

2018 ◽  
Author(s):  
Ronald Miguel Juarez Chambi ◽  
Javier A. Jo ◽  
Carmen Kut ◽  
Jesus Rico-Jimenez ◽  
Daniel U. Campos-Delgado ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Brain Tumor ◽  
Optical Coherence ◽  
Tumor Margins

scholarly journals 1131P Intraoperative assessment of negative resection margins in breast-conserving surgery using optical coherence elastography

2021 ◽  
Vol 32 ◽  
pp. S923-S924
Author(s):  
E.V. Gubarkova ◽  
A.A. Plekhanov ◽  
M.A. Sirotkina ◽  
D.A. Vorontsov ◽  
A.A. Sovetsky ◽  
...  
Keyword(s):  
Breast Conserving Surgery ◽  
Resection Margins ◽  
Optical Coherence ◽  
Intraoperative Assessment
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