scholarly journals Combined multi-modal photoacoustic tomography, optical coherence tomography (OCT) and OCT angiography system with an articulated probe for in vivo human skin structure and vasculature imaging

2016 ◽  
Vol 7 (9) ◽  
pp. 3390 ◽  
Author(s):  
Mengyang Liu ◽  
Zhe Chen ◽  
Behrooz Zabihian ◽  
Christoph Sinz ◽  
Edward Zhang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Human Skin ◽  
Oct Angiography ◽  
Photoacoustic Tomography ◽  
Optical Coherence ◽  
Skin Structure

Birefringence and vascular imaging of in vivo human skin by Jones-matrix optical coherence tomography

2017 ◽  
Author(s):  
En Li ◽  
Shuichi Makita ◽  
Young-Joo Hong ◽  
Deepa Kasaragod ◽  
Yoshiaki Yasuno
Keyword(s):  
Optical Coherence Tomography ◽  
Human Skin ◽  
Vascular Imaging ◽  
Jones Matrix ◽  
Optical Coherence

scholarly journals High-speed fiber–based polarization-sensitive optical coherence tomography of in vivo human skin

2000 ◽  
Vol 25 (18) ◽  
pp. 1355 ◽  
Author(s):  
Christopher E. Saxer ◽  
Johannes F. de Boer ◽  
B. Hyle Park ◽  
Yonghua Zhao ◽  
Zhongping Chen ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Human Skin ◽  
High Speed ◽  
Optical Coherence

scholarly journals Micro-Heterogeneity of Flow in a Mouse Model of Chronic Cerebral Hypoperfusion Revealed by Longitudinal Doppler Optical Coherence Tomography and Angiography

2015 ◽  
Vol 35 (10) ◽  
pp. 1552-1560 ◽  
Author(s):  
Vivek J Srinivasan ◽  
Esther Yu ◽  
Harsha Radhakrishnan ◽  
Anil Can ◽  
Mihail Climov ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Capillary Density ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Oct Angiography ◽  
Imaging Method ◽  
Optical Coherence ◽  
Doppler Optical Coherence Tomography ◽  
Longitudinal Imaging

Although microvascular dysfunction accompanies cognitive decline in aging, vascular dementia, and Alzheimer's disease, tools to study microvasculature longitudinally in vivo are lacking. Here, we use Doppler optical coherence tomography (OCT) and angiography for noninvasive, longitudinal imaging of mice with chronic cerebral hypoperfusion for up to 1 month. In particular, we optimized the OCT angiography method to selectively image red blood cell (RBC)-perfused capillaries, leading to a novel way of assessing capillary supply heterogeneity in vivo. After bilateral common carotid artery stenosis (BCAS), cortical blood flow measured by Doppler OCT dropped to half of baseline throughout the imaged tissue acutely. Microscopic imaging of the capillary bed with OCT angiography further revealed local heterogeneities in cortical flow supply during hypoperfusion. The number of RBC-perfused capillaries decreased, leading to increased oxygen diffusion distances in the days immediately after BCAS. Linear regression showed that RBC-perfused capillary density declined by 0.3% for a drop in flow of 1 mL/100 g per minute, and decreases in RBC-perfused capillary density as high as 25% were observed. Taken together, these results demonstrate the existence of local supply heterogeneity at the capillary level even at nonischemic global flow levels, and demonstrate a novel imaging method to assess this heterogeneity.

CHARACTERIZATION OF VITILIGO BY IN VIVO SCATTERING COEFFICIENT OF HUMAN SKIN

2011 ◽  
Vol 04 (01) ◽  
pp. 67-72 ◽  
Author(s):  
WANRONG GAO ◽  
PENG LEE ◽  
XIANLING ZHANG
Keyword(s):  
Optical Coherence Tomography ◽  
Human Skin ◽  
Experimental Results ◽  
Scattering Coefficient ◽  
Optical Coherence ◽  
Scattering Coefficients ◽  
Significant Difference

Scattering coefficients of human skin in vivo with and without vitiligo were measured with optical coherence tomography (OCT). The experimental results show that there exist significant difference between the scattering coefficient of the epidermis of in vivo human skin with and without vitiligo disease. The results may be helpful for quantitatively diagnosing or evaluating the treatment of the disease.

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