scholarly journals Exoscope-based videocapillaroscopy systemfor in vivo skin microcirculation imaging ofvarious body areas

2021 ◽  
Author(s):  
Alexander Machikhin ◽  
Mikhail V. Volkov ◽  
Demid Khokhlov ◽  
Ekaterina Lovchikova ◽  
Andrey Potemkin ◽  
...  
Keyword(s):  
Skin Microcirculation

scholarly journals Videocapillaroscopic Alterations in Alopecia Areata

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Agnieszka Gerkowicz ◽  
Dorota Krasowska ◽  
Aldona Pietrzak ◽  
Anna Michalak-Stoma ◽  
Joanna Bartosińska ◽  
...  
Keyword(s):  
Alopecia Areata ◽  
Hair Follicles ◽  
Control Group ◽  
Skin Microcirculation ◽  
Nailfold Videocapillaroscopy ◽  
Noninvasive Technique ◽  
Efferent Limb ◽  
Unknown Disturbances

Alopecia areata (AA) is a common hair disorder observed in dermatological practice; however, the exact mechanisms that lead to the hair loss are still unknown. Disturbances in the blood supply of hair follicles may be one of the elements in the complex pathogenesis of AA. Nailfold videocapillaroscopy is a noninvasive technique that allows analysis of skin microcirculation in vivo. The aim of the study was the videocapillaroscopic assessment of skin microcirculation in AA patients. The study included 44 patients with patchy alopecia areata, 27 with alopecia universalis or totalis, and 40 healthy volunteers. Nailfold videocapillaroscopy was performed in all participants according to a standard protocol. Obtained images were assessed qualitatively and quantitatively. Two types of videocapillaroscopic images were distinguished in the study. Abnormal videocapillaroscopic images were found in 42% of patients. Tortuous and branching capillaries (, ), decreased density of capillaries (), enlargement of the efferent limb (), or top part of the loop () were observed significantly more often than in the control group. Only some patients with AA presented with microvascular abnormalities characterised by altered videocapillaroscopic images. More studies, including larger group of patients with AA, are required to determine the role of observed videocapillaroscopic alterations in AA.

18669 Study of individual cell motion in healthy human skin microcirculation by in vivo reflectance confocal video microscopy

2020 ◽  
Vol 83 (6) ◽  
pp. AB217
Author(s):  
Inga Saknite ◽  
Zijun Zhao ◽  
J. Randall Patrinely ◽  
Michael Byrne ◽  
Madan Jagasia ◽  
...  
Keyword(s):  
Human Skin ◽  
Individual Cell ◽  
Video Microscopy ◽  
Skin Microcirculation ◽  
Healthy Human ◽  
Cell Motion

In vivo reflectance-mode confocal microscopy provides insights in human skin microcirculation and histomorphology

2009 ◽  
Vol 33 (7) ◽  
pp. 532-536 ◽  
Author(s):  
M.A. Altintas ◽  
M. Meyer-Marcotty ◽  
A.A. Altintas ◽  
M. Guggenheim ◽  
A. Gohritz ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Human Skin ◽  
Skin Microcirculation

PGD2 is an intermediate in agonist-stimulated nitric oxide release in rabbit skin microcirculation

1994 ◽  
Vol 266 (5) ◽  
pp. H1846-H1853
Author(s):  
J. B. Warren ◽  
R. K. Loi ◽  
A. J. Wilson
Keyword(s):  
Blood Flow ◽  
Arachidonic Acid ◽  
Skin Blood Flow ◽  
Prostaglandin D2 ◽  
Skin Microcirculation ◽  
Rabbit Skin ◽  
In Vivo Test ◽  
Prostaglandin Release

We investigated the role of endogenous prostaglandins and NO in the blood flow response of skin microcirculation in vivo. Test agents were injected intradermally in anesthetized rabbits and changes in skin blood flow measured with a laser-Doppler flow probe. Skin blood flow increased 75% at 7.33, 6.77, 11.63, 10.30, 10.55, 8.20, and < 7 -log mol/site with acetylcholine, ATP, bradykinin, prostaglandin D2 (PGD2), prostaglandin E2 (PGE2), NO gas in solution, and nitroprusside respectively. Co-injection of indomethacin (3 x 10(-9) mol/site) or NG-nitro-L-arginine methyl ester (L-NAME; 10(-7) mol/site) with either acetylcholine or bradykinin abolished the effects. This suggests a link between NO and prostaglandin release. Arachidonic acid increased blood flow, which was inhibited by indomethacin, L-NAME, or the PGD2-receptor antagonist BW-A868C. Blood flow responses to either intradermal acetyl-choline or bradykinin, but not to NO in solution, were abolished by co-injection with BW-A868C. PGD2-mediated vasodilation was abolished by L-NAME or BW-A868C, but not by indomethacin. There was no evidence of a link between NO and prostaglandin release in precontracted rabbit aortic rings in vitro. The results suggest that, in the microcirculation of rabbit skin, acetylcholine- and bradykinin-mediated vasodilation involve the arachidonic acid-PGD2-NO pathway.

scholarly journals Insight in Human Skin Microcirculation Using In Vivo Reflectance-Mode Confocal Laser Scanning Microscopy

2009 ◽  
Vol 23 (4) ◽  
pp. 475-481 ◽  
Author(s):  
Mehmet Ali Altintas ◽  
A. A. Altintas ◽  
M. Guggenheim ◽  
A. E. Steiert ◽  
M. C. Aust ◽  
...  
Keyword(s):  
Human Skin ◽  
Confocal Laser Scanning Microscopy ◽  
Laser Scanning ◽  
Laser Scanning Microscopy ◽  
Confocal Laser Scanning ◽  
Scanning Microscopy ◽  
Confocal Laser ◽  
Skin Microcirculation

The Hairless Mouse Ear for in Vivo Studies of Skin Microcirculation

1989 ◽  
Vol 83 (6) ◽  
pp. 948-959 ◽  
Author(s):  
John H. Barker ◽  
Frithjof Hammersen ◽  
Imre Bondar ◽  
Eberhard Uhl ◽  
Thomas J. Galla ◽  
...  
Keyword(s):  
Hairless Mouse ◽  
In Vivo Studies ◽  
Skin Microcirculation ◽  
Mouse Ear
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