scholarly journals Axial Accuracy and Signal Enhancement in Acoustic-Resolution Photoacoustic Microscopy by Laser Jitter Effect Correction and Pulse Energy Compensation

2021 ◽  
Author(s):  
amir asadollahi ◽  
Hamid Latifi ◽  
Manojit Pramanik ◽  
ali rezaei ◽  
Hamed Nikbakht ◽  
...  
Keyword(s):  
Pulse Energy ◽  
Signal Enhancement ◽  
Photoacoustic Microscopy ◽  
Energy Compensation

Signal Enhancement in AM-FM Interference

1994 ◽  
Author(s):  
Thomas F. Quantieri ◽  
Robert B. Dunn ◽  
Robert J. McAulay
Keyword(s):  
Signal Enhancement

scholarly journals Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Yanfeng Dai ◽  
Xiang Yu ◽  
Jianshuang Wei ◽  
Fanxin Zeng ◽  
Yiran Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Scavenger Receptor ◽  
Intradermal Injection ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Surgery ◽  
Photoacoustic Microscopy ◽  
Dual Targeting ◽  
Scavenger Receptor Class ◽  
Distinct Distribution

Abstract Detection of sentinel lymph nodes (SLNs) is critical to guide the treatment of breast cancer. However, distinguishing metastatic SLNs from normal and inflamed lymph nodes (LNs) during surgical resection remains a challenge. Here, we report a CD44 and scavenger receptor class B1 dual-targeting hyaluronic acid nanoparticle (5K-HA-HPPS) loaded with the near-infra-red fluorescent dye DiR-BOA for SLN imaging in breast cancer. The small sized (~40 nm) self-assembled 5K-HA-HPPSs accumulated rapidly in the SLNs after intradermal injection. Compared with normal popliteal LNs (N-LN), there were ~3.2-fold and ~2.4-fold increases in fluorescence intensity in tumour metastatic SLNs (T-MLN) and inflamed LNs (Inf-LN), respectively, 6 h after nanoparticle inoculation. More importantly, photoacoustic microscopy (PAM) of 5K-HA-HPPS showed a significantly distinct distribution in T-MLN compared with N-LN and Inf-LN. Signals were mainly distributed at the centre of T-MLN but at the periphery of N-LN and Inf-LN. The ratio of PA intensity (R) at the centre of the LNs compared with that at the periphery was 5.93 ± 0.75 for T-MLNs of the 5K-HA-HPPS group, which was much higher than that for the Inf-LNs (R = 0.2 ± 0.07) and N-LNs (R = 0.45 ± 0.09). These results suggest that 5K-HA-HPPS injection combined with PAM provides a powerful tool for distinguishing metastatic SLNs from pLNs and inflamed LNs, thus guiding the removal of SLNs during breast cancer surgery.

Mode-locked thulium-doped fiber laser with a narrow bandwidth and high pulse energy

2012 ◽  
Vol 9 (8) ◽  
pp. 587-590 ◽  
Author(s):  
W Zhou ◽  
D Y Shen ◽  
Y S Wang ◽  
J Y Long ◽  
Y An
Keyword(s):  
Fiber Laser ◽  
Pulse Energy ◽  
High Pulse Energy ◽  
Narrow Bandwidth ◽  
High Pulse

Raspberry-like polyamide@Ag hybrid nanoarrays with flexible cores and SERS signal enhancement strategy for adenosine detection

2021 ◽  
Vol 422 ◽  
pp. 129983
Author(s):  
Yi Li ◽  
Xiaoli Xin ◽  
Tingting Zhang ◽  
Weihua Li ◽  
Jiansheng Li ◽  
...  
Keyword(s):  
Signal Enhancement ◽  
Sers Signal

scholarly journals Filament-induced breakdown spectroscopy signal enhancement using optical wavefront control

2021 ◽  
pp. 126902
Author(s):  
L.A. Finney ◽  
J. Lin ◽  
P.J. Skrodzki ◽  
M. Burger ◽  
J. Nees ◽  
...  
Keyword(s):  
Signal Enhancement ◽  
Wavefront Control ◽  
Breakdown Spectroscopy
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