scholarly journals In-vivo mechanical characterization of coronary atherosclerotic plaques in living swine using intravascular laser speckle imaging

2021 ◽  
Vol 12 (4) ◽  
pp. 2064
Author(s):  
Zeinab Hajjarian ◽  
Jimmy D. Toussaint ◽  
J. Luis Guerrero ◽  
Seemantini K. Nadkarni
Keyword(s):  
Mechanical Characterization ◽  
Laser Speckle ◽  
Atherosclerotic Plaques ◽  
Laser Speckle Imaging ◽  
Speckle Imaging

scholarly journals Characterization of Atherosclerotic Plaques by Laser Speckle Imaging

Circulation ◽  
2005 ◽  
Vol 112 (6) ◽  
pp. 885-892 ◽  
Author(s):  
Seemantini K. Nadkarni ◽  
Brett E. Bouma ◽  
Tina Helg ◽  
Raymond Chan ◽  
Elkan Halpern ◽  
...  
Keyword(s):  
Laser Speckle ◽  
Atherosclerotic Plaques ◽  
Laser Speckle Imaging ◽  
Speckle Imaging

In vivo noninvasive visualization of retinal perfusion dysfunction in murine cerebral malaria by camera-phone laser speckle imaging

2018 ◽  
Vol 12 (1) ◽  
pp. e201800098 ◽  
Author(s):  
Itay Remer ◽  
Lorraine F. Pierre-Destine ◽  
David Tay ◽  
Linnie M. Golightly ◽  
Alberto Bilenca
Keyword(s):  
Cerebral Malaria ◽  
Laser Speckle ◽  
Camera Phone ◽  
Laser Speckle Imaging ◽  
Speckle Imaging

scholarly journals A new simulation method for laser speckle imaging to investigate hemodynamics

2019 ◽  
Vol 128 ◽  
pp. 02001
Author(s):  
X Sang ◽  
D Li ◽  
B Chen
Keyword(s):  
Speckle Pattern ◽  
Simulation Method ◽  
Laser Speckle ◽  
Contrast Imaging ◽  
Laser Speckle Imaging ◽  
Speckle Imaging ◽  
Dynamic Speckle ◽  
Speckle Size ◽  
The One

Speckle simulation is a powerful protocol to investigate the properties of speckle and evaluate image processing method. However, only static speckle images can be simulated by available methods without considering time-integrated effect of CCD. A time–integrated dynamic speckle simulation method basedon coherent imaging was developed. Through the new simulation method, the effect of speckle size on LSCI was investigated. The smaller the speckle size is, the higher the spatial resolution become.But the one-dimensional speckle size should exceed two pixels to sample the speckle pattern. The characteristics of existing speckle contrast imaging methods were studied based on spatial statistics, and optimal parameters are given to obtain accurate and less noisy image. In general, the new simulation method for laser speckle imaging is a powerful tool to monitor blood flow in vivo and lay a solid foundation for the study of hemodynamics.

Efficient characterization of regional mesenteric blood flow by use of laser speckle imaging

2003 ◽  
Vol 42 (28) ◽  
pp. 5759 ◽  
Author(s):  
Haiying Cheng ◽  
Qingming Luo ◽  
Zheng Wang ◽  
Hui Gong ◽  
Shangbin Chen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Imaging ◽  
Mesenteric Blood Flow ◽  
Speckle Imaging

scholarly journals Theranostic cranial implant for hyperspectral light delivery and microcirculation imaging without scalp removal

2019 ◽  
Author(s):  
Nami Davoodzadeh ◽  
Mildred S. Cano-Velázquez ◽  
Carrie R. Jonak ◽  
David L. Halaney ◽  
Devin K. Binder ◽  
...  
Keyword(s):  
Signal To Noise Ratio ◽  
Image Resolution ◽  
Laser Speckle ◽  
Laser Speckle Imaging ◽  
Speckle Imaging ◽  
Optical Access ◽  
Optical Attenuation ◽  
Cranial Implant ◽  
The Brain

Light based techniques for imaging, diagnosing and treating the brain have become widespread clinical tools, but application of these techniques is limited by optical attenuation in the scalp and skull. This optical attenuation reduces the achievable spatial resolution, precluding the visualization of small features such as brain microvessels. The goal of this study was to assess a strategy for providing ongoing optical access to the brain without the need for repeated craniectomy or retraction of the scalp. This strategy involves the use of a transparent cranial implant and skin optical clearing agents, and was tested in mice to assess improvements in optical access which could be achieved for laser speckle imaging of cerebral microvasculature. Combined transmittance of the optically cleared scalp overlying the transparent cranial implant was as high as 89% in the NIR range, 50% in red range, 24% in green range, and 20% in blue range. In vivo laser speckle imaging experiments of mouse cerebral blood vessels showed that the proposed optical access increased signal-to-noise ratio and image resolution, allowing for visualization of microvessels through the transparent implant, which was not possible through the uncleared scalp and intact skull.

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