scholarly journals Optical clearing agent increases effectiveness of photodynamic therapy in a mouse model of cutaneous melanoma: an analysis by Raman microspectroscopy

2020 ◽  
Vol 11 (11) ◽  
pp. 6516
Author(s):  
Letícia Palombo Martinelli ◽  
Ievgeniia Iermak ◽  
Lilian Tan Moriyama ◽  
Michelle Barreto Requena ◽  
Layla Pires ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mouse Model ◽  
Cutaneous Melanoma ◽  
Raman Microspectroscopy ◽  
Optical Clearing

Toward targeted photodynamic therapy

2011 ◽  
Vol 83 (4) ◽  
pp. 733-748 ◽  
Author(s):  
David Phillips
Keyword(s):  
Monoclonal Antibody ◽  
Photodynamic Therapy ◽  
Mouse Model ◽  
Tumor Cells ◽  
Water Solubility ◽  
Human Tumor ◽  
Antibody Fragments ◽  
Cell Kill ◽  
Pyropheophorbide A ◽  
Porphyrin Dimer

The sensitizers in common use for photodynamic therapy (PDT) are summarized, and approaches to the improvement of these outlined. Selectivity in the targeting of sensitizers to tumor cells and tissue is highly desirable, as is water solubility and prevention of aggregation. Some new free sensitizers are described, based upon the pyropheophorbide a (PPa) structure, and their photophysical properties, distribution in cells via confocal fluorescence microscopy, and cell kill properties described. A novel approach to targeting is to covalently attach such sensitizers to monoclonal antibody fragments, and recent work on the attachment of pyropheophorbide a to such monoclonal antibody fragments is reviewed, with a demonstration of the increased efficiency of cell kill, and the treatment of a solid human tumor in a mouse model described. Finally, an alternative method of achieving selectivity based upon two-photon excitation (TPE) using porphyrin dimer sensitizers is reviewed, and the use of these to kill tumor cells is compared with the use of a commercially available PDT sensitizer (Visudyne). TPE of a porphyrin dimer sensitizer is shown to be capable of sealing blood vessels in a mouse model.

The role of optical clearing to enhance the applications of in vivo OCT and photodynamic therapy: Towards PDT of pigmented melanomas and beyond

2021 ◽  
pp. 569-576
Author(s):  
Layla Pires ◽  
Michelle Barreto Requena ◽  
Valentin Demidov ◽  
Ana Gabriela Salvio ◽  
I. Alex Vitkin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Optical Clearing

Ultrastructural changes in photorejuvenation induced by photodynamic therapy in a photoaged mouse model

2013 ◽  
Vol 23 (4) ◽  
pp. 471-477 ◽  
Author(s):  
Ji-Youn Park ◽  
Yong Hyun Jang ◽  
You-Sun Kim ◽  
Seonghyang Sohn ◽  
You Chan Kim
Keyword(s):  
Photodynamic Therapy ◽  
Mouse Model ◽  
Ultrastructural Changes

Investigating the Effect of Ciliary Body Photodynamic Therapy in a Glaucoma Mouse Model

2006 ◽  
Vol 47 (6) ◽  
pp. 2498 ◽  
Author(s):  
Akihisa Matsubara ◽  
Toru Nakazawa ◽  
Deeba Husain ◽  
Eirini Iliaki ◽  
Edward Connolly ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mouse Model ◽  
Ciliary Body

scholarly journals Photodynamic therapy of oral Candida infection in a mouse model

2017 ◽  
Vol 17 ◽  
pp. A42
Author(s):  
F. Freire ◽  
C. Ferraresi ◽  
A.O.C. Jorge ◽  
M. Hamblin
Keyword(s):  
Photodynamic Therapy ◽  
Mouse Model ◽  
Candida Infection ◽  
Oral Candida

Low power photodynamic therapy for the treatment of primary breast cancer: Results from a breast cancer mouse model

2016 ◽  
Vol 42 (5) ◽  
pp. S24-S25
Author(s):  
Shramana Banerjee ◽  
Soha El Sheikh ◽  
Alexander Macrobert ◽  
Sweta Parker ◽  
Elnaz Yaghini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Mouse Model ◽  
Low Power ◽  
Primary Breast Cancer

scholarly journals Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy

Pain ◽  
2018 ◽  
Vol 159 (2) ◽  
pp. 284-297 ◽  
Author(s):  
Lisa Wright ◽  
Daniel Baptista-Hon ◽  
Fiona Bull ◽  
Faith Dalgaty ◽  
Michael Gallacher ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Mouse Model
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