scholarly journals Visible light optical coherence tomography angiography (vis-OCTA) facilitates local microvascular oximetry in the human retina

2020 ◽  
Vol 11 (7) ◽  
pp. 4037
Author(s):  
Weiye Song ◽  
Wenjun Shao ◽  
Wei Yi ◽  
Rongrong Liu ◽  
Manishi Desai ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visible Light ◽  
Optical Coherence Tomography Angiography ◽  
Human Retina ◽  
Optical Coherence

Measurement of Radial Peripapillary Capillary Density in the Normal Human Retina Using Optical Coherence Tomography Angiography

2017 ◽  
Vol 26 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Tarannum Mansoori ◽  
Jayanthi Sivaswamy ◽  
Jahnavi Sai Gamalapati ◽  
Satish Gooty Agraharam ◽  
Nagalla Balakrishna
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Capillary Density ◽  
Human Retina ◽  
Optical Coherence ◽  
Normal Human ◽  
Radial Peripapillary Capillary

scholarly journals Visible light optical coherence tomography angiography (vis-OCTA) and local microvascular retinal oximetry in human retina

2020 ◽  
Author(s):  
Weiye Song ◽  
Wenjun Shao ◽  
Wei Yi ◽  
Rongrong Liu ◽  
Manishi Desai ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visible Light ◽  
Optical Coherence Tomography Angiography ◽  
Spectral Power ◽  
Spectral Power Density ◽  
Optical Coherence ◽  
Imaging Protocol ◽  
Spectral Contrast ◽  
Accurate Localization ◽  
Acquisition Speed

AbstractWe report herein the first visible light optical coherence tomography angiography (vis-OCTA) for human retinal imaging. Compared to the existing vis-OCT systems, we devised a spectrometer with a narrower bandwidth to increase the spectral power density for OCTA imaging, while retaining the major spectral contrast in the blood. We achieved a 100 kHz A-line rate, the fastest acquisition speed reported so far for human retinal vis-OCT. We rigorously optimized the imaging protocol such that a single acquisition takes <6 seconds with a field of view (FOV) of 3×7.8 mm2. The angiography enables accurate localization of microvasculature down to the capillary level and thus enables oximetry at vessels < 100 μm in diameter. We demonstrated microvascular hemoglobin oxygen saturation (sO2) at the feeding and draining vessels at the perifoveal region. The longitudinal repeatability was assessed by <5% coefficient of variation (CV). The unique capabilities of our vis-OCTA system may allow studies on the role of microvascular oxygen in various retinal pathologies.

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