scholarly journals Quantitative OCT angiography of optic nerve head blood flow

2012 ◽  
Vol 3 (12) ◽  
pp. 3127 ◽  
Author(s):  
Yali Jia ◽  
John C. Morrison ◽  
Jason Tokayer ◽  
Ou Tan ◽  
Lorinna Lombardi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Oct Angiography

scholarly journals Effect of Tafluprost and Tafloprost/Timolol on the Optic Nerve Head, Peripapillary and Macular Microcirculation According to OCT-Angiography

2018 ◽  
Vol 15 (2) ◽  
pp. 207-213
Author(s):  
N. I. Kurysheva ◽  
D. D. Arzhukhanov ◽  
A. M. Tkhamadokova
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Open Angle Glaucoma ◽  
Ocular Blood Flow ◽  
Oct Angiography ◽  
Reference Level ◽  
Control Group ◽  
Initial Stage ◽  
Receive Treatment

Relevance. The ability of antiglaucoma drugs to improve ocular hemoperfusion is an important aspect of their action. Tafluprost is the first prostaglandin analogue (PA) containing no preservatives.  The efficacy and safety of tafluprost, as well as tafluprost/timolol  fixed combination (FC), was demonstrated in randomized multicenter  trials. However, there is no literature on the effect of  tafluprost and it’s FC on peripapillary and macular blood flow.Purpose. to assess the effect of tafluprost and tafloprost/timolol on the microcirculation in the optic nerve head, peripapillary area and  macula in patients with primary open-angle glaucoma (POAG)  according to OCT angiography (OCT-A).Patients and methods. OCT-A was performed in dynamics with an interval of a week in 36 patients (36 eyes) with a newly diagnosed  initial stage of POAG, 12 received tafluprost, 12 — tafluprost/timolol  FCs, 12 eyes represented control group (no drugs were prescribed).  The change in IOP, mean perfusion pressure (PP) of the eye, and  vessel density (VD) inside the optic nerve head (ONH) (inside disc),  as well as in the peripapillary retina and macula were evaluated by  comparing paired repeated observations using the median growth analysis.Results. In the tafluprost group there was a decrease in IOP by 19.4 % and an increase in PP by 8.7 % from the reference level. In the  tafluprost/timolol group, these figures were 43 % and 30.1 %,  respectively. OCT-A values did not change reliably, except for VD  inside Disc: in the tafluprost group, the median growth was –2.28 (p = 0.02), for the tafluprost/ timolol group — –1.82 (p = 0.03). These  changes were obtained in 11 patients of 12 in each group under  treatment. In patients who did not receive treatment, all indicators  remained unchanged.Conclusions. The results of this study showed a decrease in the density of the microcirculatory bed in the ONH in patients with initial  glaucoma against the background of the tafluprost and  tafluprost/timolol treatment, which can be explained by the  restoration of autoregulation of the ocular blood flow in conditions of  pronounced hypotensive drugs effect.

scholarly journals Effect of panretinal photocoagulation on optic nerve head blood flow with OCT angiography in patients with diabetic retinopathy

2020 ◽  
Vol 36 (5) ◽  
Author(s):  
Saher Akbar Amanat ◽  
Dr Asad Aslam Khan ◽  
Dr Haroon Tayyab ◽  
Dr Sohail Sarwar
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Optic Nerve ◽  
Proliferative Diabetic Retinopathy ◽  
Optic Nerve Head ◽  
Ocular Blood Flow ◽  
Oct Angiography ◽  
Panretinal Photocoagulation ◽  
Pan Retinal Photocoagulation ◽  
Retinal Photocoagulation

Objective: To investigate the effect of pan retinal photocoagulation (PRP) on Optic nerve head blood flow with OCT angiography in patients with proliferative diabetic retinopathy. Methods: This prospective interventional study was conducted at Eye Unit III, Institute of Ophthalmology, Mayo Hospital, Lahore, over a period of seven months i.e. from 10th May 2019 to 10th November 2019. Thirty-five patients having proliferative diabetic retinopathy were included in this study. Ocular blood flow was measured with OCT Angiography, then pan retinal photocoagulation was performed and patients were called for follow-up after one month and ocular blood flow was measured again with OCT Angiography. The difference in the blood flow was calculated. Frequencies and percentages were calculated for the categorical data and mean and standard deviations were calculated for the continuous data. Wilcoxon matched-pairs signed rank test was performed and effects of PRP on blood flow were compared. Significance level was taken as p≤0.05. Results: Out of 35 patients, 30 patients (85.71%) had decreased post PRP blood flow, four patients (11.43%) had increased post PRP blood flow and one patient (2.86%) did not have any effect. Conclusion: OCT angiography revealed there is significantly reduced optic nerve head blood flow in PRP treated eyes compared to non-PRP treated eyes. doi: https://doi.org/10.12669/pjms.36.5.2190 How to cite this:Amanat SA, Khan AA, Tayyab H, Sarwar S. Effect of panretinal photocoagulation on optic nerve head blood flow with OCT angiography in patients with diabetic retinopathy. Pak J Med Sci. 2020;36(5):---------. doi: https://doi.org/10.12669/pjms.36.5.2190 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals The Impact of Intraocular Pressure Elevation on Optic Nerve Head and Choroidal Blood Flow

2018 ◽  
Vol 59 (8) ◽  
pp. 3488 ◽  
Author(s):  
Naoki Kiyota ◽  
Yukihiro Shiga ◽  
Kohei Ichinohasama ◽  
Masayuki Yasuda ◽  
Naoko Aizawa ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Choroidal Blood Flow ◽  
Pressure Elevation ◽  
Intraocular Pressure Elevation ◽  
The Impact

scholarly journals The role of nitric oxide and endothelin on optic nerve head blood flow autoregulation

2012 ◽  
Vol 13 (Suppl 1) ◽  
pp. A28
Author(s):  
Doreen Schmidl ◽  
Agnes Boltz ◽  
Semira Kaya ◽  
René Werkmeister ◽  
Reinhard Told ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head

Effects of Fasudil, a Rho-Associated Protein Kinase Inhibitor, on Optic Nerve Head Blood Flow in Rabbits

2011 ◽  
Vol 52 (1) ◽  
pp. 64 ◽  
Author(s):  
Tetsuya Sugiyama ◽  
Maho Shibata ◽  
Sumiko Kajiura ◽  
Takashi Okuno ◽  
Masahiro Tonari ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Protein Kinase ◽  
Optic Nerve Head ◽  
Kinase Inhibitor ◽  
Protein Kinase Inhibitor

scholarly journals Clinical Usefulness of the Measurement of Optic Nerve Head Blood Flow in Myopic Normal-Tension Glaucoma

2015 ◽  
Vol 1 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Tetsuya Sugiyama ◽  
◽  
Hajime Nakamura ◽  
Emiko Shimizu ◽  
Kazuaki Miyamoto ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Normal Tension Glaucoma ◽  
Clinical Usefulness
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