scholarly journals Real-time eye motion compensation for OCT imaging with tracking SLO

2012 ◽  
Vol 3 (11) ◽  
pp. 2950 ◽  
Author(s):  
Kari V. Vienola ◽  
Boy Braaf ◽  
Christy K. Sheehy ◽  
Qiang Yang ◽  
Pavan Tiruveedhula ◽  
...  
Keyword(s):  
Real Time ◽  
Motion Compensation ◽  
Eye Motion ◽  
Oct Imaging

scholarly journals Online 4D ultrasound guidance for real-time motion compensation by MLC tracking

2016 ◽  
Vol 43 (10) ◽  
pp. 5695-5704 ◽  
Author(s):  
Svenja Ipsen ◽  
Ralf Bruder ◽  
Rick O’Brien ◽  
Paul J. Keall ◽  
Achim Schweikard ◽  
...  
Keyword(s):  
Real Time ◽  
Motion Compensation ◽  
Ultrasound Guidance ◽  
Time Motion ◽  
4D Ultrasound

scholarly journals High-Resolution Quantitative Mapping of Macaque Cervicovaginal Epithelial Thickness: Implications for Mucosal Vaccine Delivery

2021 ◽  
Vol 12 ◽  
Author(s):  
Kathleen L. Vincent ◽  
Patrice A. Frost ◽  
Massoud Motamedi ◽  
Edward J. Dick ◽  
Jingna Wei ◽  
...  
Keyword(s):  
High Resolution ◽  
Immune Responses ◽  
Real Time ◽  
Basal Layer ◽  
Mucosal Vaccine ◽  
P Value ◽  
Mechanical Abrasion ◽  
Mucosal Vaccination ◽  
Epithelial Thickness ◽  
Oct Imaging

Vaginal mucosal surfaces naturally offer some protection against sexually transmitted infections (STIs) including Human Immunodeficiency Virus-1, however topical preventative medications or vaccine designed to boost local immune responses can further enhance this protection. We previously developed a novel mucosal vaccine strategy using viral vectors integrated into mouse dermal epithelium to induce virus-specific humoral and cellular immune responses at the site of exposure. Since vaccine integration occurs at the site of cell replication (basal layer 100-400 micrometers below the surface), temporal epithelial thinning during vaccine application, confirmed with high resolution imaging, is desirable. In this study, strategies for vaginal mucosal thinning were evaluated noninvasively using optical coherence tomography (OCT) to map reproductive tract epithelial thickness (ET) in macaques to optimize basal layer access in preparation for future effective intravaginal mucosal vaccination studies. Twelve adolescent female rhesus macaques (5-7kg) were randomly assigned to interventions to induce vaginal mucosal thinning, including cytobrush mechanical abrasion, the chemical surfactant spermicide nonoxynol-9 (N9), the hormonal contraceptive depomedroxyprogesterone acetate (DMPA), or no intervention. Macaques were evaluated at baseline and after interventions using colposcopy, vaginal biopsies, and OCT imaging, which allowed for real-time in vivo visualization and measurement of ET of the mid-vagina, fornices, and cervix. P value ≤0.05 was considered significant. Colposcopy findings included pink, rugated tissue with variable degrees of white-tipped, thickened epithelium. Baseline ET of the fornices was thinner than the cervix and vagina (p<0.05), and mensing macaques had thinner ET at all sites (p<0.001). ET was decreased 1 month after DMPA (p<0.05) in all sites, immediately after mechanical abrasion (p<0.05) in the fornix and cervix, and after two doses of 4% N9 (1.25ml) applied over 14 hrs in the fornix only (p<0.001). Histological assessment of biopsied samples confirmed OCT findings. In summary, OCT imaging allowed for real time assessment of macaque vaginal ET. While varying degrees of thinning were observed after the interventions, limitations with each were noted. ET decreased naturally during menses, which may provide an ideal opportunity for accessing the targeted vaginal mucosal basal layers to achieve the optimum epithelial thickness for intravaginal mucosal vaccination.

Lung Tumor Motion Compensation during Real Time Respiratory Tracking using Gold Fiducial Markers

2008 ◽  
Vol 72 (1) ◽  
pp. S464-S465 ◽  
Author(s):  
K. Huang ◽  
S. Hossain ◽  
C. Chuang ◽  
M. Descovich ◽  
A. Gottschalk ◽  
...  
Keyword(s):  
Real Time ◽  
Motion Compensation ◽  
Lung Tumor ◽  
Fiducial Markers ◽  
Tumor Motion ◽  
Respiratory Tracking
Sign in / Sign up

Export Citation Format

Share Document