scholarly journals Aperture phase modulation with adaptive optics: a novel approach for speckle reduction and structure extraction in optical coherence tomography

2019 ◽  
Vol 10 (2) ◽  
pp. 552 ◽  
Author(s):  
Pengfei Zhang ◽  
Suman K. Manna ◽  
Eric B. Miller ◽  
Yifan Jian ◽  
Ratheesh K. Meleppat ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Adaptive Optics ◽  
Phase Modulation ◽  
Speckle Reduction ◽  
Optical Coherence ◽  
Novel Approach ◽  
Structure Extraction

scholarly journals Aperture Phase Modulation with Adaptive Optics: A Novel Approach for Speckle Reduction and Structure Extraction in Optical Coherence Tomography

2018 ◽  
Author(s):  
Pengfei Zhang ◽  
Suman K. Manna ◽  
Eric B. Miller ◽  
Yifan Jian ◽  
Ratheesh Kumar Meleppat ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Adaptive Optics ◽  
Phase Modulation ◽  
Imaging System ◽  
Speckle Pattern ◽  
Speckle Noise ◽  
Image Resolution ◽  
Speckle Reduction ◽  
Universal Method ◽  
Optical Coherence

Abstract:Speckle is an inevitable consequence of the use of coherent light in optical coherence tomography (OCT), and often acts as noise that obscures micro-structures of biological tissue. We here present a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) in OCT system: by modulating the phase inside the imaging system pupil aperture with a segmented deformable mirror, thus producing minor perturbations in the point spread function (PSF) to create un-correlated speckle pattern between B-scans, and further averaging to wash out the speckle but maintain the structures. It is a well-controlled and universal method which can efficiently determine the optimal range of phase modulation that minimizing speckle noise while maximizing image resolution and signal strength for different systems and/or samples. As an active method, its effectiveness and efficiency were demonstrated by both ex-vivo non-biological and in-vivo biological applications.

Speckle reduction in optical coherence tomography by frequency compounding

2003 ◽  
Vol 8 (3) ◽  
pp. 565 ◽  
Author(s):  
Michael Pircher ◽  
Erich Götzinger ◽  
Rainer Leitgeb ◽  
Adolf F. Fercher ◽  
Christoph. K. Hitzenberger
Keyword(s):  
Optical Coherence Tomography ◽  
Speckle Reduction ◽  
Optical Coherence

Speckle reduction in optical coherence tomography by two-step image registration

2015 ◽  
Vol 20 (3) ◽  
pp. 036013 ◽  
Author(s):  
Hang Zhang ◽  
Zhongliang Li ◽  
Xiangzhao Wang ◽  
Xiangyang Zhang
Keyword(s):  
Optical Coherence Tomography ◽  
Image Registration ◽  
Speckle Reduction ◽  
Optical Coherence
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