Laser-induced Breakdown Spectroscopy (LIBS) based tissue type mapping of ex-vivo soft tissues - A prospect for tissue specific Laser surgery

2017 ◽  
Author(s):  
Fanuel Mehari ◽  
Bastian Geißler ◽  
Maximilian Rohde ◽  
Florian Klämpfl ◽  
Florian Stelzle ◽  
...  
Keyword(s):  
Laser Surgery ◽  
Soft Tissues ◽  
Ex Vivo ◽  
Tissue Type ◽  
Laser Induced Breakdown Spectroscopy ◽  
Tissue Specific ◽  
Breakdown Spectroscopy ◽  
Type Mapping ◽  
Laser Induced Breakdown

scholarly journals The differentiation of oral soft- and hard tissues using laser induced breakdown spectroscopy - a prospect for tissue specific laser surgery

2016 ◽  
Vol 10 (10) ◽  
pp. 1250-1261 ◽  
Author(s):  
Maximilian Rohde ◽  
Fanuel Mehari ◽  
Florian Klämpfl ◽  
Werner Adler ◽  
Friedrich-Wilhelm Neukam ◽  
...  
Keyword(s):  
Laser Surgery ◽  
Laser Induced Breakdown Spectroscopy ◽  
Tissue Specific ◽  
Breakdown Spectroscopy ◽  
Hard Tissues ◽  
Laser Induced Breakdown

scholarly journals Methodology for the Implementation of Internal Standard to Laser-Induced Breakdown Spectroscopy Analysis of Soft Tissues

Sensors ◽  
2021 ◽  
Vol 21 (3) ◽  
pp. 900
Author(s):  
Anna Šindelářová ◽  
Pavel Pořízka ◽  
Pavlína Modlitbová ◽  
Lucie Vrlíková ◽  
Kateřina Kiss ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Internal Standard ◽  
Laser Induced Breakdown Spectroscopy ◽  
Biological Research ◽  
Elemental Content ◽  
Ambient Atmosphere ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
Signal Response

The improving performance of the laser-induced breakdown spectroscopy (LIBS) triggered its utilization in the challenging topic of soft tissue analysis. Alterations of elemental content within soft tissues are commonly assessed and provide further insights in biological research. However, the laser ablation of soft tissues is a complex issue and demands a priori optimization, which is not straightforward in respect to a typical LIBS experiment. Here, we focus on implementing an internal standard into the LIBS elemental analysis of soft tissue samples. We achieve this by extending routine methodology for optimization of soft tissues analysis with a standard spiking method. This step enables a robust optimization procedure of LIBS experimental settings. Considering the implementation of LIBS analysis to the histological routine, we avoid further alterations of the tissue structure. Therefore, we propose a unique methodology of sample preparation, analysis, and subsequent data treatment, which enables the comparison of signal response from heterogenous matrix for different LIBS parameters. Additionally, a brief step-by-step process of optimization to achieve the highest signal-to-noise ratio (SNR) is described. The quality of laser–tissue interaction is investigated on the basis of the zinc signal response, while selected experimental parameters (e.g., defocus, gate delay, laser energy, and ambient atmosphere) are systematically modified.

Classification of soft tissues using laser-induced breakdown spectroscopy

2017 ◽  
Author(s):  
Xiaohui Li ◽  
Xiaokang An ◽  
Rongwei Fan ◽  
Xin Yu ◽  
Deying Chen
Keyword(s):  
Soft Tissues ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown
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