LED-based Phase Imaging Interference Microscopy with Multi-Wavelength Optical Phase Unwrapping

2006 ◽  
Author(s):  
N. Warnasooriya ◽  
M. K. Kim
Keyword(s):  
Phase Unwrapping ◽  
Interference Microscopy ◽  
Phase Imaging ◽  
Optical Phase ◽  
Multi Wavelength

scholarly journals LED-based multi-wavelength phase imaging interference microscopy

2007 ◽  
Vol 15 (15) ◽  
pp. 9239 ◽  
Author(s):  
N. Warnasooriya ◽  
M. K. Kim
Keyword(s):  
Interference Microscopy ◽  
Phase Imaging ◽  
Multi Wavelength

scholarly journals Robust Phase Unwrapping via Deep Image Prior for Quantitative Phase Imaging

2021 ◽  
pp. 1-1
Author(s):  
Fangshu Yang ◽  
Thanh-an Pham ◽  
Nathalie Brandenberg ◽  
Matthias P. Lutolf ◽  
Jianwei Ma ◽  
...  
Keyword(s):  
Phase Unwrapping ◽  
Phase Imaging ◽  
Quantitative Phase Imaging ◽  
Quantitative Phase ◽  
Image Prior ◽  
Deep Image

Optical phase imaging of living organisms inside the Airy disk

1994 ◽  
Author(s):  
Vladimir P. Tychinsky ◽  
Georgy E. Koufal ◽  
Alex Odintsov ◽  
Tatiana V. Vyshenskaia
Keyword(s):  
Phase Imaging ◽  
Optical Phase ◽  
Living Organisms ◽  
Airy Disk

scholarly journals Quantitative Histopathology of Stained Tissues using Color Spatial Light Interference Microscopy (cSLIM)

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Hassaan Majeed ◽  
Adib Keikhosravi ◽  
Mikhail E. Kandel ◽  
Tan H. Nguyen ◽  
Yuming Liu ◽  
...  
Keyword(s):  
New Technologies ◽  
Imaging Modality ◽  
Interference Microscopy ◽  
Phase Imaging ◽  
Bright Field Image ◽  
Interferometric Imaging ◽  
Breast Cancer Patients ◽  
Prognostic Information ◽  
Light Interference ◽  
Tissue Phase

Abstract Tissue biopsy evaluation in the clinic is in need of quantitative disease markers for diagnosis and, most importantly, prognosis. Among the new technologies, quantitative phase imaging (QPI) has demonstrated promise for histopathology because it reveals intrinsic tissue nanoarchitecture through the refractive index. However, a vast majority of past QPI investigations have relied on imaging unstained tissues, which disrupts the established specimen processing. Here we present color spatial light interference microscopy (cSLIM) as a new whole-slide imaging modality that performs interferometric imaging on stained tissue, with a color detector array. As a result, cSLIM yields in a single scan both the intrinsic tissue phase map and the standard color bright-field image, familiar to the pathologist. Our results on 196 breast cancer patients indicate that cSLIM can provide stain-independent prognostic information from the alignment of collagen fibers in the tumor microenvironment. The effects of staining on the tissue phase maps were corrected by a mathematical normalization. These characteristics are likely to reduce barriers to clinical translation for the new cSLIM technology.

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