Endoscopic Fourier Domain Optical Coherence Tomography for Bladder Cancer Diagnosis

2006 ◽  
Author(s):  
Zhenguo Wang ◽  
Hongyu Wang ◽  
Zhijia Yuan ◽  
Zilu Wu ◽  
Yingtian Pan
Keyword(s):  
Bladder Cancer ◽  
Optical Coherence Tomography ◽  
Cancer Diagnosis ◽  
Fourier Domain ◽  
Optical Coherence

OPTICAL COHERENCE TOMOGRAPHY FOR BLADDER CANCER DIAGNOSIS: FROM ANIMAL STUDY TO CLINICAL DIAGNOSIS

2008 ◽  
Vol 01 (01) ◽  
pp. 125-140 ◽  
Author(s):  
ZHIJIA YUAN ◽  
HUGANG REN ◽  
WAYNE WALTZER ◽  
JASON KIM ◽  
JINGXUAN LIU ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Optical Coherence Tomography ◽  
Cancer Diagnosis ◽  
In Vivo Imaging ◽  
Laser Scanning ◽  
Dynamic Range ◽  
Morphological Changes ◽  
Optical Coherence ◽  
Cancerous Lesions

This paper summarizes the recent technological development in our lab on cystoscopic optical coherence tomography (COCT) by integrating time-domain OCT (TDOCT) and spectral-domain OCT (SDOCT) with advanced MEMS-mirror technology for endoscopic laser scanning imaging. The COCT catheter can be integrated into the instrument channel of a commercial 22Fr rigid cystoscopic sheath for in vivo imaging of human bladder under the cystosocopic visual guidance; the axial/transverse resolutions of the COCT catheter are roughly 9 μm and 12 μm, respectively, and 2D COCT imaging can be performed with over 110dB dynamic range at 4–8 fps. To examine the utility and potential limitations of OCT for bladder cancer diagnosis, systemic ex vivo rat bladder carcinogenesis studies were performed to follow various morphological changes induced by tumor growth and in vivo porcine study was performed to examine the feasibility of COCT for in vivo imaging. Justified by promising results of the animal studies, preliminary clinical study was conducted on patients scheduled for operating-room cystoscopy for bladder cancers. Double-blind clinical results reveal that COCT can delineate detailed bladder architectures (e.g., urothelium, lamina propria, muscularis) at high resolution and detect bladder cancers based on enhanced urothelial heterogeneity as a result of excessive growing nature of bladder cancers. The diagnostic sensitivity and specificity can be enhanced to 92% and 85%, respectively. Results also suggest that due to reduced imaging depth of COCT in cancerous lesions, staging of bladder cancers may be limited to Ta or T1 for non-outgrowing cancerous lesions.

1227: Optical Coherence Tomography-Guided Surgery of Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 395-395
Author(s):  
Nancy J. Tresser ◽  
Elena V. Zagaynova ◽  
Olga S. Streltsova ◽  
Natalia D. Gladkova ◽  
Vladislav A. Kamensky ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Guided Surgery

Reliability and Reproducibility of Assessment of Corneal Epithelial Thickness by Fourier Domain Optical Coherence Tomography

2012 ◽  
Vol 53 (6) ◽  
pp. 2580 ◽  
Author(s):  
Gaurav Prakash ◽  
Amar Agarwal ◽  
Anjum Iqbal Mazhari ◽  
Mathangi Chari ◽  
Dhivya Ashok Kumar ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Corneal Epithelial ◽  
Epithelial Thickness ◽  
Corneal Epithelial Thickness

Raman-pumped Fourier-domain mode-locked laser: analysis of operation and application for optical coherence tomography

2008 ◽  
Vol 33 (23) ◽  
pp. 2815 ◽  
Author(s):  
Thomas Klein ◽  
Wolfgang Wieser ◽  
Benjamin R. Biedermann ◽  
Christoph M. Eigenwillig ◽  
Gesa Palte ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Laser Analysis ◽  
Mode Locked Laser
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