Calculation of task-evoked changes in the cerebral metabolic rate of oxygen consumption from simultaneous ASL-BOLD fMRI and Diffuse Optical Imaging

2004 ◽  
Author(s):  
T.J. Huppert ◽  
R.D. Hoge ◽  
M.A. Franceschini ◽  
D.A. Boas
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Optical Imaging ◽  
Diffuse Optical Imaging ◽  
Bold Fmri ◽  
Cerebral Metabolic Rate ◽  
Rate Of Oxygen Consumption

scholarly journals Quantitative real-time optical imaging of the tissue metabolic rate of oxygen consumption

2018 ◽  
Vol 23 (03) ◽  
pp. 1 ◽  
Author(s):  
Michael T. Ghijsen ◽  
Griffin R. Lentsch ◽  
Sylvain Gioux ◽  
Matthew Brenner ◽  
Anthony J. Durkin ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Optical Imaging ◽  
Real Time ◽  
Rate Of Oxygen Consumption

scholarly journals Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity

NeuroImage ◽  
2019 ◽  
Vol 184 ◽  
pp. 717-728 ◽  
Author(s):  
M. Germuska ◽  
H.L. Chandler ◽  
R.C. Stickland ◽  
C. Foster ◽  
F. Fasano ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Cerebral Metabolic Rate ◽  
Oxygen Diffusivity ◽  
Rate Of Oxygen Consumption ◽  
Calibrated Fmri

scholarly journals Rapid magnetic resonance measurement of global cerebral metabolic rate of oxygen consumption in humans during rest and hypercapnia

2011 ◽  
Vol 31 (7) ◽  
pp. 1504-1512 ◽  
Author(s):  
Varsha Jain ◽  
Michael C Langham ◽  
Thomas F Floyd ◽  
Gaurav Jain ◽  
Jeremy F Magland ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Oxygen Consumption ◽  
Magnetic Resonance ◽  
Metabolic Rate ◽  
Vascular Reactivity ◽  
Cerebral Metabolism ◽  
Metabolic Effects ◽  
Cerebral Metabolic Rate ◽  
Rate Of Oxygen Consumption ◽  
End Tidal

The effect of hypercapnia on cerebral metabolic rate of oxygen consumption ( CMRO2) has been a subject of intensive investigation and debate. Most applications of hypercapnia are based on the assumption that a mild increase in partial pressure of carbon dioxide has negligible effect on cerebral metabolism. In this study, we sought to further investigate the vascular and metabolic effects of hypercapnia by simultaneously measuring global venous oxygen saturation ( Sv O2) and total cerebral blood flow ( tCBF), with a temporal resolution of 30 seconds using magnetic resonance susceptometry and phase-contrast techniques in 10 healthy awake adults. While significant increases in Sv O2 and tCBF were observed during hypercapnia ( P < 0.005), no change in CMRO2 was noted ( P > 0.05). Additionally, fractional changes in tCBF and end-tidal carbon dioxide ( R2 = 0.72, P < 0.005), as well as baseline Sv O2 and tCBF ( R2 = 0.72, P < 0.005), were found to be correlated. The data also suggested a correlation between cerebral vascular reactivity ( CVR) and baseline tCBF ( R2 = 0.44, P = 0.052). A CVR value of 6.1% ± 1.6%/mm Hg was determined using a linear-fit model. Additionally, an average undershoot of 6.7% ± 4% and 17.1% ± 7% was observed in Sv O2 and tCBF upon recovery from hypercapnia in six subjects.

scholarly journals Multiplexed MRI methods for rapid estimation of global cerebral metabolic rate of oxygen consumption

NeuroImage ◽  
2017 ◽  
Vol 149 ◽  
pp. 393-403 ◽  
Author(s):  
Hyunyeol Lee ◽  
Michael C. Langham ◽  
Ana E. Rodriguez-Soto ◽  
Felix W. Wehrli
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Rapid Estimation ◽  
Cerebral Metabolic Rate ◽  
Rate Of Oxygen Consumption

scholarly journals Estimation of the regional cerebral metabolic rate of oxygen consumption with proton detected 17O MRI during precision 17O2 inhalation in swine

2009 ◽  
Vol 179 (1) ◽  
pp. 29-39 ◽  
Author(s):  
Eric A. Mellon ◽  
R. Shashank Beesam ◽  
James E. Baumgardner ◽  
Arijitt Borthakur ◽  
Walter R. Witschey ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Cerebral Metabolic Rate ◽  
Rate Of Oxygen Consumption

Sleep-dependent changes in the cerebral metabolic rate of oxygen consumption in newborn lambs

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S85-S85
Author(s):  
Alessandro Silvani ◽  
Valentina Asti ◽  
Chiara Berteotti ◽  
Tijana Bojic ◽  
Vera Ferrari ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Cerebral Metabolic Rate ◽  
Rate Of Oxygen Consumption

scholarly journals High Temporal Resolution MRI Quantification of Global Cerebral Metabolic Rate of Oxygen Consumption in Response to Apneic Challenge

2013 ◽  
Vol 33 (10) ◽  
pp. 1514-1522 ◽  
Author(s):  
Zachary B Rodgers ◽  
Varsha Jain ◽  
Erin K Englund ◽  
Michael C Langham ◽  
Felix W Wehrli
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Temporal Resolution ◽  
Healthy Adults ◽  
High Temporal Resolution ◽  
View Sharing ◽  
Cerebral Metabolic Rate ◽  
Sagittal Sinus ◽  
Rate Of Oxygen Consumption

We present a technique for quantifying global cerebral metabolic rate of oxygen consumption (CMRO2) in absolute physiologic units at 3-second temporal resolution and apply the technique to quantify the dynamic CMRO2 response to volitional apnea. Temporal resolution of 3 seconds was achieved via a combination of view sharing and superior sagittal sinus-based estimation of total cerebral blood flow (tCBF) rather than tCBF measurement in the neck arteries. These modifications were first validated in three healthy adults and demonstrated to produce minimal errors in image-derived blood flow and venous oxygen saturation (SvO2) values. The technique was then applied in 10 healthy adults during an apnea paradigm of three repeated 30-second breath-holds. Subject-averaged baseline tCBF, arteriovenous oxygen difference (AVO2D), and CMRO2 were 48.6±7.0 mL/100 g per minute, 29.4 ± 3.4%HbO2, and 125.1±11.4 μmol/100 g per minute, respectively. Subject-averaged maximum changes in tCBF and AVO2D were 43.5±9.4% and − 32.1±5.7%, respectively, resulting in a small (6.0±3.5%) but statistically significant ( P = 0.00044, two-tailed t-test) increase in average end-apneic CMRO2. This method could be used to investigate neurometabolic-hemodynamic relationships in normal physiology, to better define the biophysical origins of the BOLD signal, and to quantify neurometabolic responsiveness in diseases of altered neurovascular reactivity.

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