In Vivo Three-dimensional Multi-spectral Diffuse Optical Tomography of Breast Cancer

2004 ◽  
Author(s):  
Regine Choe ◽  
Alper Corlu ◽  
Kijoon Lee ◽  
Turgut Durduran ◽  
Britton Chance ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Optical Tomography ◽  
Three Dimensional ◽  
Diffuse Optical Tomography

scholarly journals Three-dimensional in vivo fluorescence diffuse optical tomography of breast cancer in humans

2007 ◽  
Vol 15 (11) ◽  
pp. 6696 ◽  
Author(s):  
Alper Corlu ◽  
Regine Choe ◽  
Turgut Durduran ◽  
Mark A. Rosen ◽  
Martin Schweiger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Optical Tomography ◽  
Three Dimensional ◽  
Diffuse Optical Tomography ◽  
In Vivo Fluorescence ◽  
Fluorescence Diffuse Optical Tomography

scholarly journals Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography

2009 ◽  
Vol 14 (2) ◽  
pp. 024020 ◽  
Author(s):  
Regine Choe ◽  
Soren D. Konecky ◽  
Alper Corlu ◽  
Kijoon Lee ◽  
Turgut Durduran ◽  
...  
Keyword(s):  
Parallel Plate ◽  
Optical Tomography ◽  
Three Dimensional ◽  
Diffuse Optical Tomography ◽  
Breast Tumors ◽  
Malignant Breast

Three-dimensional imaging of in vivo bones and joints with diffuse optical tomography

2002 ◽  
Author(s):  
Huabei Jiang ◽  
Yong Xu ◽  
Nicusor Iftimia ◽  
L. Lyndon Key ◽  
Marcy B. Bolster
Keyword(s):  
Optical Tomography ◽  
Three Dimensional ◽  
Diffuse Optical Tomography ◽  
Three Dimensional Imaging

scholarly journals Imaging the Human Thyroid Using Three-Dimensional Diffuse Optical Tomography: A Preliminary Study

2021 ◽  
Vol 11 (4) ◽  
pp. 1670
Author(s):  
Tetsuya Mimura ◽  
Shinpei Okawa ◽  
Hiroshi Kawaguchi ◽  
Yukari Tanikawa ◽  
Yoko Hoshi
Keyword(s):  
Optical Tomography ◽  
Tumor Hypoxia ◽  
Three Dimensional ◽  
Diffuse Optical Tomography ◽  
Element Model ◽  
Needle Aspiration ◽  
Human Thyroid ◽  
Tissue Oxygen Saturation ◽  
Preliminary Study ◽  
First Time

Thyroid cancer is usually diagnosed by ultrasound imaging and fine-needle aspiration biopsy. However, diagnosis of follicular thyroid carcinomas (FTC) is difficult because FTC lacks nuclear atypia and a consensus on histological interpretation. Diffuse optical tomography (DOT) offers the potential to diagnose FTC because it can measure tumor hypoxia, while image reconstruction of the thyroid is still challenging mainly due to the complex anatomical features of the neck. In this study, we attempted to solve this issue by creating a finite element model of the human neck excluding the trachea (a void region). By reconstruction of the absorption coefficients at three wavelengths, 3D tissue oxygen saturation maps of the human thyroid are obtained for the first time by DOT.

Prevascularized, Co-Culture Model for Breast Cancer Drug Development

2012 ◽  
Author(s):  
Lauren Marshall ◽  
Isabel Löwstedt ◽  
Paul Gatenholm ◽  
Joel Berry
Keyword(s):  
Breast Cancer ◽  
Drug Development ◽  
Three Dimensional ◽  
Human Tumor ◽  
3D Models ◽  
Cancer Drug ◽  
Cancer Therapies ◽  
Anti Cancer

The objective of this study was to create 3D engineered tissue models to accelerate identification of safe and efficacious breast cancer drug therapies. It is expected that this platform will dramatically reduce the time and costs associated with development and regulatory approval of anti-cancer therapies, currently a multi-billion dollar endeavor [1]. Existing two-dimensional (2D) in vitro and in vivo animal studies required for identification of effective cancer therapies account for much of the high costs of anti-cancer medications and health insurance premiums borne by patients, many of whom cannot afford it. An emerging paradigm in pharmaceutical drug development is the use of three-dimensional (3D) cell/biomaterial models that will accurately screen novel therapeutic compounds, repurpose existing compounds and terminate ineffective ones. In particular, identification of effective chemotherapies for breast cancer are anticipated to occur more quickly in 3D in vitro models than 2D in vitro environments and in vivo animal models, neither of which accurately mimic natural human tumor environments [2]. Moreover, these 3D models can be multi-cellular and designed with extracellular matrix (ECM) function and mechanical properties similar to that of natural in vivo cancer environments [3].

Three-dimensional surface reconstruction within noncontact diffuse optical tomography using structured light

2012 ◽  
Vol 17 (12) ◽  
pp. 126009 ◽  
Author(s):  
Kirstin Baum ◽  
Raimo Hartmann ◽  
Tobias Bischoff ◽  
Jan O. Oelerich ◽  
Stephan Finkensieper ◽  
...  
Keyword(s):  
Surface Reconstruction ◽  
Structured Light ◽  
Optical Tomography ◽  
Three Dimensional ◽  
Diffuse Optical Tomography ◽  
Dimensional Surface

Acceleration of the EM-like reconstruction method for diffuse optical tomography with ordered-subsets method

2014 ◽  
Vol 22 (3) ◽  
Author(s):  
Caifang Wang
Keyword(s):  
Numerical Experiments ◽  
Imaging Modality ◽  
Random Medium ◽  
Optical Tomography ◽  
Back Propagation ◽  
Three Dimensional ◽  
Diffuse Optical Tomography ◽  
Optical Parameters ◽  
Reconstruction Method ◽  
Boundary Measurements

Abstract.Diffuse optical tomography (DOT) is an optical imaging modality, which provides the spatial distribution of the optical parameters inside a random medium. A propagation back-propagation method named EM-like reconstruction method for stationary DOT problem has been proposed yet. This method is really time consuming. Hence the ordered-subsets (OS) technique for this reconstruction method is studied in this paper. The boundary measurements of DOT are grouped into nonoverlapping and overlapping ordered sequence of subsets with random partition, sequential partition and periodic partition, respectively. The performance of OS methods is compared with the standard EM-like reconstruction method with two-dimensional and three-dimensional numerical experiments. The numerical experiments indicate that reconstruction of nonoverlapping subsets with periodic partition, overlapping subsets with periodic partition and standard EM-like method provide very similar acceptable reconstruction results. However, reconstruction of nonoverlapping subsets with periodic partition spends a minimum of time to get proper results.

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