Near-infrared tomography as a model-based imaging modality

Author(s):  
Keith Paulsen
2002 ◽  
Vol 7 (1) ◽  
pp. 72 ◽  
Author(s):  
Troy O. McBride ◽  
Brian W. Pogue ◽  
Steven Poplack ◽  
Sandra Soho ◽  
Wendy A. Wells ◽  
...  

2021 ◽  
Vol 22 (9) ◽  
pp. 4804
Author(s):  
Vincent Q. Sier ◽  
Joost R. van der Vorst ◽  
Paul H. A. Quax ◽  
Margreet R. de Vries ◽  
Elham Zonoobi ◽  
...  

Molecular imaging of pathologic lesions can improve efficient detection of cancer and cardiovascular diseases. A shared pathophysiological feature is angiogenesis, the formation of new blood vessels. Endoglin (CD105) is a coreceptor for ligands of the Transforming Growth Factor-β (TGF-β) family and is highly expressed on angiogenic endothelial cells. Therefore, endoglin-based imaging has been explored to visualize lesions of the aforementioned diseases. This systematic review highlights the progress in endoglin-based imaging of cancer, atherosclerosis, myocardial infarction, and aortic aneurysm, focusing on positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), near-infrared fluorescence (NIRF) imaging, and ultrasound imaging. PubMed was searched combining the following subjects and their respective synonyms or relevant subterms: “Endoglin”, “Imaging/Image-guided surgery”. In total, 59 papers were found eligible to be included: 58 reporting about preclinical animal or in vitro models and one ex vivo study in human organs. In addition to exact data extraction of imaging modality type, tumor or cardiovascular disease model, and tracer (class), outcomes were described via a narrative synthesis. Collectively, the data identify endoglin as a suitable target for intraoperative and diagnostic imaging of the neovasculature in tumors, whereas for cardiovascular diseases, the evidence remains scarce but promising.


2004 ◽  
Vol 43 (5) ◽  
pp. 1053 ◽  
Author(s):  
Xiaomei Song ◽  
Brian W. Pogue ◽  
Shudong Jiang ◽  
Marvin M. Doyley ◽  
Hamid Dehghani ◽  
...  

2013 ◽  
Vol 740-742 ◽  
pp. 405-408 ◽  
Author(s):  
Ivan G. Ivanov ◽  
Andreas Gällström ◽  
Stefano Leone ◽  
Olof Kordina ◽  
Nguyen Tien Son ◽  
...  

A set of lines in the photoluminescence spectra of 4H-, 6H-, and 15R-SiC in the near-infrared are attributed to Nb-related defects on the ground of doping experiments conducted with 4H-SiC. A model based on a an exciton bound at the Nb-centre in an asymmetric split vacancy configuration at a hexagonal site is proposed, which explains the structure of the luminescence spectrum and the observed Zeeman splitting of the lines.


Author(s):  
Luis Octavio Tierradentro-García ◽  
Sandra Saade-Lemus ◽  
Colbey Freeman ◽  
Matthew Kirschen ◽  
Hao Huang ◽  
...  

Objective Hypoxic-ischemic encephalopathy (HIE) in infants can have long-term adverse neurodevelopmental effects and markedly reduce quality of life. Both the initial hypoperfusion and the subsequent rapid reperfusion can cause deleterious effects in brain tissue. Cerebral blood flow (CBF) assessment in newborns with HIE can help detect abnormalities in brain perfusion to guide therapy and prognosticate patient outcomes. Study Design The review will provide an overview of the pathophysiological implications of CBF derangements in neonatal HIE, current and emerging techniques for CBF quantification, and the potential to utilize CBF as a physiologic target in managing neonates with acute HIE. Conclusion The alterations of CBF in infants during hypoxia-ischemia have been studied by using different neuroimaging techniques, including nitrous oxide and xenon clearance, transcranial Doppler ultrasonography, contrast-enhanced ultrasound, arterial spin labeling MRI, 18F-FDG positron emission tomography, near-infrared spectroscopy (NIRS), functional NIRS, and diffuse correlation spectroscopy. Consensus is lacking regarding the clinical significance of CBF estimations detected by these different modalities. Heterogeneity in the imaging modality used, regional versus global estimations of CBF, time for the scan, and variables impacting brain perfusion and cohort clinical characteristics should be considered when translating the findings described in the literature to routine practice and implementation of therapeutic interventions. Key Points


2017 ◽  
Vol 38 (1) ◽  
pp. 109-116 ◽  
Author(s):  
王儒敬 WANG Ru-jing ◽  
陈天娇 CHEN Tian-jiao ◽  
汪玉冰 WANG Yu-bing ◽  
汪六三 WANG Liu-san ◽  
谢成军 XIE Cheng-jun ◽  
...  

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