Dynamic Hemoglobin Concentration Imaging Using A Simultaneous Two Wavelength Near-infrared Diffuse Optical Tomography System

2002 ◽  
Author(s):  
Shudong Jiang ◽  
Brian W. Pogue ◽  
Troy O. McBride ◽  
Keith D. Paulsen
Keyword(s):  
Near Infrared ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Hemoglobin Concentration ◽  
Tomography System

scholarly journals Design and implementation of a multifrequency near-infrared diffuse optical tomography system

2006 ◽  
Vol 11 (1) ◽  
pp. 014020 ◽  
Author(s):  
Gultekin Gulsen ◽  
Bin Xiong ◽  
Ozlem Birgul ◽  
Orhan Nalcioglu
Keyword(s):  
Near Infrared ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Design And Implementation ◽  
Tomography System

scholarly journals Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers

Sensors ◽  
2020 ◽  
Vol 20 (10) ◽  
pp. 2815
Author(s):  
David Orive-Miguel ◽  
Laura Di Sieno ◽  
Anurag Behera ◽  
Edoardo Ferocino ◽  
Davide Contini ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Near Infrared ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Brain Activation ◽  
Functional Brain Imaging ◽  
Dual Wavelength ◽  
Silicon Photomultipliers ◽  
Functional Brain ◽  
Tomography System

Near-infrared diffuse optical tomography is a non-invasive photonics-based imaging technology suited to functional brain imaging applications. Recent developments have proved that it is possible to build a compact time-domain diffuse optical tomography system based on silicon photomultipliers (SiPM) detectors. The system presented in this paper was equipped with the same eight SiPM probe-hosted detectors, but was upgraded with six injection fibers to shine the sample at several points. Moreover, an automatic switch was included enabling a complete measurement to be performed in less than one second. Further, the system was provided with a dual-wavelength (670 n m and 820 n m ) light source to quantify the oxy- and deoxy-hemoglobin concentration evolution in the tissue. This novel system was challenged against a solid phantom experiment, and two in-vivo tests, namely arm occlusion and motor cortex brain activation. The results show that the tomographic system makes it possible to follow the evolution of brain activation over time with a 1 s -resolution.

scholarly journals Age-related changes in diffuse optical tomography sensitivity profiles in infancy

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252036
Author(s):  
Xiaoxue Fu ◽  
John E. Richards
Keyword(s):  
Near Infrared ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Hemoglobin Concentration ◽  
Separation Distance ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Photon Propagation ◽  
Age Related ◽  
Wide Range

Diffuse optical tomography uses near-infrared light spectroscopy to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of the location that generates the hemodynamic signal requires accurate descriptions of diffuse optical tomography sensitivity to the underlying cortical structures. Such information is limited for pediatric populations because they undergo rapid head and brain development. The present study used photon propagation simulation methods to examine diffuse optical tomography sensitivity profiles in realistic head models among infants ranging from 2 weeks to 24 months with narrow age bins, children (4 and 12 years) and adults (20 to 24 years). The sensitivity profiles changed systematically with the source-detector separation distance. The peak of the sensitivity function in the head was largest at the smallest separation distance and decreased as separation distance increased. The fluence value dissipated more quickly with sampling depth at the shorter source-detector separations than the longer separation distances. There were age-related differences in the shape and variance of sensitivity profiles across a wide range of source-detector separation distances. Our findings have important implications in the design of sensor placement and diffuse optical tomography image reconstruction in (functional) near-infrared light spectroscopy research. Age-appropriate realistic head models should be used to provide anatomical guidance for standalone near-infrared light spectroscopy data in infants.

scholarly journals Investigating Developmental Changes in Scalp-Cortex Correspondence Using Diffuse Optical Tomography Sensitivity in Infancy

2020 ◽  
Author(s):  
Xiaoxue Fu ◽  
John E. Richards
Keyword(s):  
Near Infrared ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Hemoglobin Concentration ◽  
Infrared Light ◽  
Photon Propagation ◽  
Age Related ◽  
Age Appropriate ◽  
Pediatric Populations ◽  
Cortical Regions

AbstractSignificanceDiffuse optical tomography (DOT) uses near-infrared light spectroscopy (NIRS) to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of NIRS data requires accurate descriptions of the cranio-cerebral relations and DOT sensitivity to the underlying cortical structures. Such information is limited for pediatric populations because they undergo rapid head and brain development.AimThe present study aimed to investigate age-related differences in scalp-to-cortex distance and mapping between scalp locations and cortical regions of interest (ROIs) among infants (2 weeks to 24 months with narrow age bins), children (4 and 12 years) and adults (20 to 24 years).ApproachWe used spatial scalp projection and photon propagation simulation methods with age-matched realistic head models based on MRIs.ResultsThere were age-group differences in the scalp-to-cortex distances in infancy. The developmental increase was magnified in children and adults. There were systematic age-related differences in the probabilistic mappings between scalp locations and cortical ROIs.ConclusionsOur findings have important implications in the design of sensor placement and making anatomical interpretations in NIRS and fNIRS research. Age-appropriate realistic head models should be used to provide anatomical guidance for standalone DOT data in infants.

Development of near-infrared swept laser based diffuse optical tomography system

2012 ◽  
Author(s):  
Jaedu Cho ◽  
Yuting Lin ◽  
Gultekin Gulsen ◽  
Orhan Nalcioglu ◽  
Myung Yung Jeong ◽  
...  
Keyword(s):  
Near Infrared ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Tomography System

scholarly journals A Near-Infrared Optical Tomography System Based on Photomultiplier Tube

2007 ◽  
Vol 2007 ◽  
pp. 1-9 ◽  
Author(s):  
Huacheng Feng ◽  
Jing Bai ◽  
Xiaolei Song ◽  
Gang Hu ◽  
Junjie Yao
Keyword(s):  
Breast Cancer ◽  
Spectral Range ◽  
Near Infrared ◽  
Continuous Wave ◽  
Imaging System ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Experimental Results ◽  
Photomultiplier Tube ◽  
Tomography System

Diffuse optical tomography (DOT) is a rapidly growing discipline in recent years. It plays an important role in many fields, such as detecting breast cancer and monitoring the cerebra oxygenation. In this paper, a relatively simple, inexpensive, and conveniently used DOT system is presented in detail, in which only one photomultiplier tube is employed as the detector and an optical multiplexer is used to alter the detector channels. The 32-channel imager is consisted of 16-launch fibers and 16-detector fibers bundles, which works in the near-infrared (NIR) spectral range under continuous-wave (CW) model. The entire imaging system can work highly automatically and harmoniously. Experiments based on the proposed imaging system were performed, and the desired results can be obtained. The experimental results suggested that the proposed imaging instrumentation is effective.

scholarly journals Functional imaging of the human brain using a modular, fibre-less, high-density diffuse optical tomography system

2016 ◽  
Vol 7 (10) ◽  
pp. 4275 ◽  
Author(s):  
Danial Chitnis ◽  
Robert J. Cooper ◽  
Laura Dempsey ◽  
Samuel Powell ◽  
Simone Quaggia ◽  
...  
Keyword(s):  
Human Brain ◽  
Functional Imaging ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
High Density ◽  
Tomography System
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