Computational study of a label-free biosensor based on a photonic crystal nanocavity resonator

2013 ◽  
Vol 52 (29) ◽  
pp. 7206 ◽  
Author(s):  
Saeed Olyaee ◽  
Samira Najafgholinezhad
Keyword(s):  
Photonic Crystal ◽  
Computational Study ◽  
Label Free ◽  
Nanocavity Resonator

scholarly journals Photonic Crystal Nanobeam Cavities for Nanoscale Optical Sensing: A Review

Micromachines ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 72 ◽  
Author(s):  
Da-Quan Yang ◽  
Bing Duan ◽  
Xiao Liu ◽  
Ai-Qiang Wang ◽  
Xiao-Gang Li ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Optical Waveguides ◽  
Optical Sensing ◽  
Early Stage ◽  
Disease Diagnosis ◽  
Label Free ◽  
Quality Factors ◽  
Integrated Sensor ◽  
Early Stage Disease ◽  
Wide Range

The ability to detect nanoscale objects is particular crucial for a wide range of applications, such as environmental protection, early-stage disease diagnosis and drug discovery. Photonic crystal nanobeam cavity (PCNC) sensors have attracted great attention due to high-quality factors and small-mode volumes (Q/V) and good on-chip integrability with optical waveguides/circuits. In this review, we focus on nanoscale optical sensing based on PCNC sensors, including ultrahigh figure of merit (FOM) sensing, single nanoparticle trapping, label-free molecule detection and an integrated sensor array for multiplexed sensing. We believe that the PCNC sensors featuring ultracompact footprint, high monolithic integration capability, fast response and ultrahigh sensitivity sensing ability, etc., will provide a promising platform for further developing lab-on-a-chip devices for biosensing and other functionalities.

scholarly journals Label-free Imaging of Stem Cell Adhesion and Dynamic Tracking of Boundary Evolution Using Photonic Crystal Enhanced Microscopy (PCEM)

2017 ◽  
Vol 23 (S1) ◽  
pp. 1142-1143 ◽  
Author(s):  
Yue Zhuo ◽  
Ji Sun Choi ◽  
Thibault Marin ◽  
Hojeong Yu ◽  
Brendan A. Harley ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Adhesion ◽  
Photonic Crystal ◽  
Label Free ◽  
Dynamic Tracking

High sensitivity and high Q-factor nanoslotted parallel quadrabeam photonic crystal cavity for real-time and label-free sensing

2014 ◽  
Vol 105 (6) ◽  
pp. 063118 ◽  
Author(s):  
Daquan Yang ◽  
Shota Kita ◽  
Feng Liang ◽  
Cheng Wang ◽  
Huiping Tian ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Real Time ◽  
High Sensitivity ◽  
Q Factor ◽  
Label Free ◽  
Photonic Crystal Cavity ◽  
High Q

Photonic crystals: A platform for label-free and enhanced fluorescence biomolecular and cellular assays

2008 ◽  
Vol 1133 ◽  
Author(s):  
Brian T. Cunningham ◽  
Leo Chan ◽  
Patrick C. Mathias ◽  
Nikhil Ganesh ◽  
Sherine George ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Photonic Crystals ◽  
High Throughput Screening ◽  
High Sensitivity ◽  
Excitation Wavelength ◽  
Label Free ◽  
Crystal Surfaces ◽  
Enhanced Fluorescence ◽  
Preferred Direction ◽  
Label Free Detection

Abstract Photonic crystal surfaces represent a class of resonant optical structures that are capable of supporting high intensity electromagnetic standing waves with near-field and far-field properties that can be exploited for high sensitivity detection of biomolecules and cells. While modulation of the resonant wavelength of a photonic crystal by the dielectric permittivity of adsorbed biomaterials enables label-free detection, the resonance can also be tuned to coincide with the excitation wavelength of common fluorescent tags - including organic molecules and semiconductor quantum dots. Photonic crystals are also capable of efficiently channeling fluorescent emission into a preferred direction for enhanced extraction efficiency. Photonic crystals can be designed to support multiple resonant modes that can perform label free detection, enhanced fluorescence excitation, and enhanced fluorescence extraction simultaneously on the same device. Because photonic crystal surfaces may be inexpensively produced over large surface areas by nanoreplica molding processes, they can be incorporated into disposable labware for applications such as pharmaceutical high throughput screening. In this talk, the optical properties of surface photonic crystals will be reviewed and several applications will be described, including results from screening a 200,000-member chemical compound library for inhibitors of protein-DNA interactions, gene expression microarrays, and high sensitivity of protein biomarkers.

Photonic crystal surface mode imaging for multiplexed and high-throughput label-free biosensing

2020 ◽  
Vol 168 ◽  
pp. 112575 ◽  
Author(s):  
Valery Konopsky ◽  
Tatiana Mitko ◽  
Konstantin Aldarov ◽  
Elena Alieva ◽  
Dmitry Basmanov ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
High Throughput ◽  
Crystal Surface ◽  
Surface Mode ◽  
Label Free
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