Monte Carlo procedure for investigating light propagation and imaging of highly scattering media

1998 ◽  
Vol 37 (31) ◽  
pp. 7392 ◽  
Author(s):  
Angelo Sassaroli ◽  
Costantino Blumetti ◽  
Fabrizio Martelli ◽  
Lucia Alianelli ◽  
Daniele Contini ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Light Propagation ◽  
Scattering Media ◽  
Monte Carlo Procedure

scholarly journals Holistic Monte-Carlo optical modelling of biological imaging

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Guillem Carles ◽  
Paul Zammit ◽  
Andrew R. Harvey
Keyword(s):  
Monte Carlo ◽  
Ray Tracing ◽  
Light Propagation ◽  
Scattered Light ◽  
Light Sheet ◽  
Neural Cells ◽  
Scattering Media ◽  
Confocal Scanning ◽  
Confocal Scanning Laser ◽  
User Friendly

Abstract The invention and advancement of biological microscopy depends critically on an ability to accurately simulate imaging of complex biological structures embedded within complex scattering media. Unfortunately no technique exists for rigorous simulation of the complete imaging process, including the source, instrument, sample and detector. Monte-Carlo modelling is the gold standard for the modelling of light propagation in tissue, but is somewhat laborious to implement and does not incorporate the rejection of scattered light by the microscope. On the other hand microscopes may be rigorously and rapidly modelled using commercial ray-tracing software, but excluding the interaction with the biological sample. We report a hybrid Monte-Carlo optical ray-tracing technique for modelling of complete imaging systems of arbitrary complexity. We make the software available to enable user-friendly and rigorous virtual prototyping of biological microscopy of arbitrary complexity involving light scattering, fluorescence, polarised light propagation, diffraction and coherence. Examples are presented for the modelling and optimisation of representative imaging of neural cells using light-sheet and micro-endoscopic fluorescence microscopy and imaging of retinal vasculature using confocal and non-confocal scanning-laser ophthalmoscopes.

scholarly journals Parallelized Monte Carlo software to efficiently simulate the light propagation in arbitrarily shaped objects and aligned scattering media

2018 ◽  
Vol 23 (06) ◽  
pp. 1 ◽  
Author(s):  
Christian Johannes Zoller ◽  
Ansgar Hohmann ◽  
Florian Foschum ◽  
Simeon Geiger ◽  
Martin Geiger ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Light Propagation ◽  
Scattering Media
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