Image plane adjustment in photoacoustic tomography based on a full ring transducer array

2016 ◽  
Author(s):  
Zhong Ji ◽  
Wenzheng Ding
Keyword(s):  
Image Plane ◽  
Photoacoustic Tomography ◽  
Transducer Array

A high-speed photoacoustic tomography system based on a commercial ultrasound and a custom transducer array

2010 ◽  
Author(s):  
Xueding Wang ◽  
Jonathan Cannata ◽  
Derek DeBusschere ◽  
Changhong Hu ◽  
J. Brian Fowlkes ◽  
...  
Keyword(s):  
High Speed ◽  
Photoacoustic Tomography ◽  
Transducer Array ◽  
Tomography System

scholarly journals Enhancement of photoacoustic tomography by ultrasonic computed tomography based on optical excitation of elements of a full-ring transducer array

2013 ◽  
Vol 38 (16) ◽  
pp. 3140 ◽  
Author(s):  
Jun Xia ◽  
Chao Huang ◽  
Konstantin Maslov ◽  
Mark A. Anastasio ◽  
Lihong V. Wang
Keyword(s):  
Computed Tomography ◽  
Optical Excitation ◽  
Photoacoustic Tomography ◽  
Transducer Array

scholarly journals Clinically-translatable High-fidelity Photoacoustic Tomography Enhanced by Virtual Point Sources

2021 ◽  
Author(s):  
Junjie Yao ◽  
Yuqi Tang ◽  
Shanshan Tang ◽  
Chengwu Huang ◽  
Shigao Chen
Keyword(s):  
Contrast Agents ◽  
Point Sources ◽  
Blood Oxygenation ◽  
Clinical Translation ◽  
Photoacoustic Tomography ◽  
High Fidelity ◽  
Local Pressure ◽  
Transducer Array ◽  
Image Fidelity ◽  
Virtual Point

Abstract Photoacoustic tomography (PAT), a hybrid imaging modality that acoustically detects the optical absorption contrast, is a promising technology for imaging hemodynamic functions in deep tissues. Particularly, PAT is capable of measuring the blood oxygenation level using hemoglobin as the endogenous contrast. However, the most clinically compatible PAT configuration usually employs a linear ultrasound transducer array and often suffers from the poor image fidelity, mostly due to the limited detection view of the transducer array. PAT can be improved by employing highly-absorbing contrast agents such as droplets and nanoparticles, which, however, have low clinical translation potential due to safety concerns and regulatory hurdles. Moreover, unlike hemoglobin, these exogenous contrast agents cannot report the functional hemodynamic information. In this work, we have developed a new methodology that can improve PAT’s image fidelity without hampering its functional capability or clinical translation potential. By using clinically-approved microbubbles as virtual point sources that strongly scatter the local pressure waves generated by surrounding hemoglobin, we can overcome the limited-detection-view problem and achieve high-fidelity functional PAT in deep tissues, a technology referred to as virtual-point-source PAT (VPS-PAT). We have thoroughly investigated the working principle of VPS-PAT by numerical simulations and phantom validations, showing the acoustic origin of signal enhancement and the superiority over traditional PAT. We have also demonstrated proof-of-concept applications of functional VPT-PAT for in vivo small-animal studies with physiological challenges. We expect that VPS-PAT can find broad applications in biomedical research and accelerated translation to clinical impact.

Measurements in 3D images

1991 ◽  
Vol 49 ◽  
pp. 408-409
Author(s):  
John C. Russ
Keyword(s):  
Three Dimensional ◽  
Image Plane ◽  
X Rays ◽  
Traditional Use ◽  
3D Images ◽  
Confocal Scanning Laser Microscope ◽  
Hard Materials ◽  
Depth Direction ◽  
Confocal Scanning ◽  
Confocal Scanning Laser

Three-dimensional (3D) images consisting of arrays of voxels can now be routinely obtained from several different types of microscopes. These include both the transmission and emission modes of the confocal scanning laser microscope (but not its most common reflection mode), the secondary ion mass spectrometer, and computed tomography using electrons, X-rays or other signals. Compared to the traditional use of serial sectioning (which includes sequential polishing of hard materials), these newer techniques eliminate difficulties of alignment of slices, and maintain uniform resolution in the depth direction. However, the resolution in the z-direction may be different from that within each image plane, which makes the voxels non-cubic and creates some difficulties for subsequent analysis.

Comparison of Conventional and Electron Spectroscopic Imaging in the Fixed Beam Electron Microscope of Ordered Protein Arrays

1985 ◽  
Vol 43 ◽  
pp. 74-75
Author(s):  
E. L. Buhle ◽  
U. Aebi
Keyword(s):  
Image Processing ◽  
Electron Microscope ◽  
High Resolution ◽  
Image Plane ◽  
Electron Spectroscopic Imaging ◽  
Protein Arrays ◽  
Beam Electron ◽  
Average Unit ◽  
Fixed Beam ◽  
Energy Components

CTEM brightfield images are formed by a combination of relatively high resolution elastically scattered electrons and unscattered and inelastically scattered electrons. In the case of electron spectroscopic images (ESI), the inelastically scattered electrons cause a loss of both contrast and spatial resolution in the image. In the case of ESI imaging on the Zeiss EM902, the transmited electrons are dispersed into their various energy components by passing them through a magnetic prism spectrometer; a slit is then placed in the image plane of the prism to select the electrons of a given energy loss for image formation. The purpose of this study was to compare CTEM with ESI images recorded on a Zeiss EM902 of ordered protein arrays. Digital image processing was employed to analyze the average unit cell morphologies of the two types of images.

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