Fluorescent magnetic nanopaticles-labeled murine embryonic stem cells for targeted identification of <italic>in vivo</italic> gastric cancer cells

2013 ◽  
Vol 58 (7) ◽  
pp. 593-600
Author(s):  
Chao LI ◽  
DaXiang CUI ◽  
Jing RUAN ◽  
Jun CHEN ◽  
Hua SONG
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cancer Cells ◽  
Embryonic Stem ◽  
Gastric Cancer Cells ◽  
Murine Embryonic Stem Cells

scholarly journals DiR-labeled Embryonic Stem Cells for Targeted Imaging of in vivo Gastric Cancer Cells

Theranostics ◽  
2012 ◽  
Vol 2 (6) ◽  
pp. 618-628 ◽  
Author(s):  
Jing Ruan ◽  
Hua Song ◽  
Chao Li ◽  
Chenchen Bao ◽  
Hualin Fu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Cancer Cells ◽  
Embryonic Stem ◽  
Targeted Imaging ◽  
Gastric Cancer Cells

Differentiation of Lung Epithelial Cells from Murine Embryonic Stem Cells with in Vivo Implantation

2013 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Christine Finck ◽  
Blair Roszell ◽  
Todd Jensen ◽  
Ariel Seaton ◽  
Fan Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Epithelial Cells ◽  
Embryonic Stem ◽  
Lung Epithelial Cells ◽  
Murine Embryonic Stem Cells ◽  
Lung Epithelial

scholarly journals Surface antigen phenotypes of hematopoietic stem cells from embryos and murine embryonic stem cells

Blood ◽  
2009 ◽  
Vol 114 (2) ◽  
pp. 268-278 ◽  
Author(s):  
Shannon L. McKinney-Freeman ◽  
Olaia Naveiras ◽  
Frank Yates ◽  
Sabine Loewer ◽  
Marsha Philitas ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Hematopoietic Stem Cells ◽  
Fetal Liver ◽  
Embryonic Stem ◽  
Hematopoietic Stem ◽  
Murine Embryonic Stem Cells ◽  
Isolation And Characterization

Abstract Surface antigens on hematopoietic stem cells (HSCs) enable prospective isolation and characterization. Here, we compare the cell-surface phenotype of hematopoietic repopulating cells from murine yolk sac, aorta-gonad-mesonephros, placenta, fetal liver, and bone marrow with that of HSCs derived from the in vitro differentiation of murine embryonic stem cells (ESC-HSCs). Whereas c-Kit marks all HSC populations, CD41, CD45, CD34, and CD150 were developmentally regulated: the earliest embryonic HSCs express CD41 and CD34 and lack CD45 and CD150, whereas more mature HSCs lack CD41 and CD34 and express CD45 and CD150. ESC-HSCs express CD41 and CD150, lack CD34, and are heterogeneous for CD45. Finally, although CD48 was absent from all in vivo HSCs examined, ESC-HSCs were heterogeneous for the expression of this molecule. This unique phenotype signifies a developmentally immature population of cells with features of both primitive and mature HSC. The prospective fractionation of ESC-HSCs will facilitate studies of HSC maturation essential for normal functional engraftment in irradiated adults.

T.P.2.13 Murine embryonic stem cells injected into mdx mouse – In vivo myogenic capacity and immunogenic reaction

2008 ◽  
Vol 18 (9-10) ◽  
pp. 759-760
Author(s):  
D. Ayub-Guerrieri ◽  
P.C.M. Martins ◽  
P.C.G. Onofre ◽  
V.F. Lopes ◽  
L.V. Pereira ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mdx Mouse ◽  
Murine Embryonic Stem Cells

Suppressor of Fused Plays an Important Role in Regulating Mesodermal Differentiation of Murine Embryonic Stem Cells In Vivo

2015 ◽  
Vol 24 (21) ◽  
pp. 2547-2560 ◽  
Author(s):  
Maria A. Hoelzl ◽  
Karin Heby-Henricson ◽  
Ganna Bilousova ◽  
Björn Rozell ◽  
Raoul V. Kuiper ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Suppressor Of Fused ◽  
Murine Embryonic Stem Cells

scholarly journals G6PD-NF-κB-HGF Signal in Gastric Cancer-Associated Mesenchymal Stem Cells Promotes the Proliferation and Metastasis of Gastric Cancer Cells by Upregulating the Expression of HK2

2021 ◽  
Vol 11 ◽  
Author(s):  
Bin Chen ◽  
Tuo Cai ◽  
Chao Huang ◽  
Xueyan Zang ◽  
Li Sun ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Cancer Cells ◽  
Underlying Mechanism ◽  
Enzyme Linked Immunosorbent Assay ◽  
Gastric Cancer Cells ◽  
Proliferation And Metastasis

Background: Tumor-associated stromal cells have been widely recognized for their tumor-promoting capability involving paracrine signaling. However, the underlying mechanism and the effects of the molecules in the glycolysis pathway in gastric cancer-associated mesenchymal stem cells (GCMSCs) and gastric cancer cells on tumor progression remain unclear.Methods: The expression of hepatocyte growth factor (HGF) in GCMSCs and bone marrow mesenchymal stem cells (BMMSCs) was detected by enzyme-linked immunosorbent assay (ELISA). The effect of HGF derived from GCMSCs on the proliferation, metastasis, and HK2 expression of gastric cancer cells was evaluated in vitro and in vivo. The effects of G6PD on the production of HGF in mesenchymal stem cells (MSCs) were analyzed by immunoblotting.Results: HGF derived from GCMSCs promoted glycolysis, proliferation, and metastasis of gastric cancer by upregulating c-Myc-HK2 signal. The progression of the disease induced by GCMSCs decelerated in the absence of HK2. The expression of G6PD activated NF-κB signaling and stimulated the production of HGF in GCMSCs. Blocking HGF derived from GCMSCs decreased proliferation, metastasis, and angiogenesis of gastric cancer cells in vivo.Conclusions: GCMSCs highly expressed G6PD and facilitated the progression of gastric cancer through the G6PD-NF-κB-HGF axis coordinates. Blocking HGF derived from GCMSCs is a potential new therapeutic target for the treatment of gastric cancer.

scholarly journals In Vivo Molecular Imaging of Murine Embryonic Stem Cells Delivered to a Burn Wound Surface via Integra® Scaffolding

2012 ◽  
Vol 33 (2) ◽  
pp. e49-e54 ◽  
Author(s):  
Victoria F. Hamrahi ◽  
Jeremy Goverman ◽  
Walter Jung ◽  
Joseph C. Wu ◽  
Alan J. Fischman ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Molecular Imaging ◽  
Embryonic Stem ◽  
Wound Surface ◽  
Burn Wound ◽  
Murine Embryonic Stem Cells
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