Insulin-like growth factor 2 as a candidate gene influencing growth and carcass traits and its bialleleic expression in chicken

2005 ◽  
Vol 48 (2) ◽  
pp. 187 ◽  
Author(s):  
Genyu WANG
Keyword(s):  
Growth Factor ◽  
Candidate Gene ◽  
Carcass Traits ◽  
Insulin Like Growth Factor

Insulin-like growth factor 2 as a candidate gene influencing growth and carcass traits and its bialleleic expression in chicken

2005 ◽  
Vol 48 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Genyu Wang ◽  
Bingxue Yan ◽  
Xuemei Deng ◽  
Changlü Li ◽  
Xiaoxiang Hu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Candidate Gene ◽  
Carcass Traits ◽  
Insulin Like Growth Factor

Differential methylation of insulin-like growth factor 2 in offspring of physically active pregnant women

2018 ◽  
Vol 9 (3) ◽  
pp. 299-306 ◽  
Author(s):  
M. R. Marshall ◽  
N. Paneth ◽  
J. A. Gerlach ◽  
L. M. Mudd ◽  
L. Biery ◽  
...  
Keyword(s):  
Physical Activity ◽  
Dna Methylation ◽  
Growth Factor ◽  
Candidate Gene ◽  
Pyruvate Dehydrogenase Kinase ◽  
Peroxisome Proliferator ◽  
Insulin Like Growth Factor ◽  
Gene Methylation ◽  
Global Methylation ◽  
Peroxisome Proliferator Activated Receptor

AbstractSeveral studies have suggested that maternal lifestyle during pregnancy may influence long-term health of offspring by altering the offspring epigenome. Whether maternal leisure-time physical activity (LTPA) during pregnancy might have this effect is unknown. The purpose of this study was to determine the relationship between maternal LTPA during pregnancy and offspring DNA methylation. Participants were recruited from the Archive for Research on Child Health study. At enrollment, participants’ demographic information and self-reported LTPA during pregnancy were determined. High active participants (averaged 637.5 min per week of LTPA; n=14) were matched by age and race to low active participants (averaged 59.5 min per week LTPA; n=28). Blood spots were obtained at birth. Pyrosequencing was used to determine methylation levels of long interspersed nucleotide elements (LINE-1) (global methylation) and peroxisome proliferator-activated receptor-gamma (PPARγ), peroxisome proliferator-activated receptor-gamma coactivator (PGC1-α), insulin-like growth factor 2 (IGF2), pyruvate dehydrogenase kinase, isozyme 4 (PDK4) and transcription factor 7-like 2 (TCF7L2). We found no differences between offspring of high active and low active groups for LINE-1 methylation. The only differences in candidate gene methylation between groups were at two CpG sites in the P2 promoter of IGF2; the offspring of low active group had significantly higher DNA methylation (74.70±2.25% methylation for low active v. 72.83±2.85% methylation for high active; P=0.045). Our results suggest no effect of maternal LTPA on offspring global and candidate gene methylation, with the exception of IGF2. IGF2 has been previously associated with regulation of physical activity, suggesting a possible role of maternal LTPA on regulation of offspring physical activity.

Insulin-like growth factor-I gene polymorphism and its association with growth and slaughter characteristics in broiler chickens

2011 ◽  
Vol 28 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Jaromír Kadlec ◽  
Božena Hosnedlová ◽  
Václav Řehout ◽  
Jindřich Čítek ◽  
Libor Večerek ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Polymorphism ◽  
Candidate Gene ◽  
Broiler Chickens ◽  
Liver Weight ◽  
Phenotypic Traits ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
I Gene

Insulin-like growth factor-I gene polymorphism and its association with growth and slaughter characteristics in broiler chickensChicken insulin-like factor 1 gene (IGF1) is a biological candidate gene for the investigation of growth, body composition, and metabolic and skeletal traits, and is also a positional candidate gene for growth and fat deposition in chickens. Two broiler populations Ross 308 and Cobb 500 were used to study the relationship between IGF1 gene polymorphism and phenotypic traits. A single nucleotide polymorphism (SNP) was identified in 132 individuals using the PCR-RFLP technique. Genotypical frequencies were, for genotype AA: 0.83-0.86, and for AC: 0.14-0.17. Associations between IGF1 promotor polymorphism and liver weight (P≤0.05) and liver weight as a percentage of the weight of the poultry carcass with the giblets (P≤0.05), were found in the AC genotype in a comparison of broiler homozygous chickens AA in the Cobb 500 line. In these broilers, the breast muscle and leg muscle weight in the AC genotype were higher, and abdominal fat weight lower compared with AA genotype chickens, but these differences were not significant.

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