Study on the ternary ion-association complex nanoparticles of palladium(II)-famotidine and halogen-fluorescein dyes by the resonance Rayleigh scattering and their application

2011 ◽  
Vol 41 (6) ◽  
pp. 1059-1067
Author(s):  
ShaoPu LIU ◽  
ZhongFang LIU ◽  
XiaoLi HU ◽  
PeiLi CHEN
Keyword(s):  
Rayleigh Scattering ◽  
Ion Association ◽  
Resonance Rayleigh Scattering ◽  
Fluorescein Dyes ◽  
Association Complex

Resonance Rayleigh Scattering for the Determination of Chlorpromazine and Promethazine

2006 ◽  
Vol 59 (12) ◽  
pp. 915 ◽  
Author(s):  
Lanxiang An ◽  
Shaopu Liu ◽  
Zhongfang Liu ◽  
Ling Kong ◽  
Xiaoli Hu
Keyword(s):  
Reaction Mechanism ◽  
Drug Concentration ◽  
Rayleigh Scattering ◽  
Ion Association ◽  
Resonance Rayleigh Scattering ◽  
Optimum Conditions ◽  
Serum Samples ◽  
Spectroscopic Characteristics ◽  
Urine And Serum

Chlorpromazine (CPZ) and promethazine (PZ) can react with potassium ferrioxalate (PF) to form 3:1 ion-association complexes, which can result in a significant enhancement of resonance Rayleigh scattering (RRS) intensity. The maximum scattering peaks are located at 368 nm for CPZ-PF and 370 nm for PZ-PF. The RRS spectroscopic characteristics, the optimum conditions of reactions, and influencing factors have been studied for CPZ-PF and PZ-PF. There is a linear relationship between the RRS intensity and the drug concentration in the range of 0.02–8.00 μg mL–1 for CPZ and 0.04–9.00 μg mL–1 for PZ, and the detection limits (3σ) are 6.6 ng mL–1 for CPZ and 10.6 ng mL–1 for PZ. The proposed method has been applied to determine CPZ in urine and serum samples with satisfactory results. Moreover, the reaction mechanism and the reasons for intensity enhancement of RRS have been discussed.

scholarly journals Investigating the interaction of terbinafine with xanthenes dye for its feasible determination applying the resonance Rayleigh scattering technique

2021 ◽  
Vol 8 (1) ◽  
pp. 201545
Author(s):  
Mohamed A. Abdel-Lateef ◽  
Sayed M. Derayea ◽  
Deena A. M. Nour El-Deen ◽  
Albandary Almahri ◽  
Mohamed Oraby
Keyword(s):  
Rayleigh Scattering ◽  
Ion Association ◽  
Pharmaceutical Formulations ◽  
Resonance Rayleigh Scattering ◽  
Complexation Reaction ◽  
Hydrophobic Force ◽  
Terbinafine Hydrochloride ◽  
Erythrosine B ◽  
Quantitation Limit

Terbinafine hydrochloride is a potent antifungal drug indicated for oral and topical treatment of mycoses. A resonance Rayleigh scattering (RRS) method was developed for the determination of terbinafine hydrochloride through a feasible complexation reaction with erythrosine B. In a weakly acidic medium (acetate buffer, pH 5.0), terbinafine hydrochloride can react with erythrosine B through the electrostatic attraction and virtue of hydrophobic force to form an ion-association complex. The reaction resulted in the appearance of a new RRS peak at 369 nm. The RRS peak was increased by increasing the concentration of terbinafine hydrochloride in the linear range of 0.1–1.5 µg ml −1 . All the reaction conditions (erythrosine B concentration, buffer volume, diluting solvent and pH) were optimized. The detection limit was 0.029 µg ml −1 while the quantitation limit was 0.089 µg ml −1 . The suggested method after its validation was successfully applied for the determination of terbinafine hydrochloride in different pharmaceutical formulations (tablets and cream) with sufficient recovery.

scholarly journals Two facile approaches based on association complex with erythrosine-B for nano-level analysis of duloxetine: application to content uniformity

2021 ◽  
Vol 8 (9) ◽  
Author(s):  
Sayed M. Derayea ◽  
Ramadan Ali ◽  
Ahmed A. Abu-hassan
Keyword(s):  
Rayleigh Scattering ◽  
Limit Of Detection ◽  
Resonance Rayleigh Scattering ◽  
Content Uniformity ◽  
Analysis And Evaluation ◽  
Erythrosine B ◽  
Spectrofluorimetric Method ◽  
Formulation Analysis ◽  
Level Analysis ◽  
Association Complex

Duloxetine is an antidepressant that exhibits its action by preventing the reuptake of serotonin and norepinephrine by neurons. In this analytical study, we developed two facile, sensitive methods for duloxetine analysis. Both methods rely on the formation of binary association complex between erythrosine-B and duloxetine in an acidic medium using spectrofluorimetric and resonance Rayleigh scattering (RRS) techniques. Spectrofluorimetric method simply uses the quenching property of the formed complex on the native fluorescence of erythrosine-B at an emission wavelength of 557.2 nm ( λ ex = 528.6), while RRS is based on detecting the enhancement in the RRS signal at 357.2 nm. The proposed methods have been validated according to the International Conference on Harmonization guidelines. The approaches provide linear assay of duloxetine hydrochloride over 0.1–2.4 µg ml −1 and 0.2–2.0 µg ml −1 for spectrofluorimetric and RRS methods, respectively. Variables affecting methods and complex formation were studied and optimized. The limit of detection values were 0.03 and 0.056 µg ml −1 for spectrofluorimetric and RRS methods, respectively. Both approaches were applied with acceptable results for formulation analysis and evaluation of cymbatex capsule content uniformity.

The Resonance Rayleigh Scattering Spectrum Characteristic of Tb3+-GMFX-AR and the Determination of Gemifloxacin

2014 ◽  
Vol 881-883 ◽  
pp. 65-69
Author(s):  
Hui Ping Xi ◽  
Xiu Wei Fang
Keyword(s):  
Detection Limit ◽  
Hydrophobic Interaction ◽  
Rayleigh Scattering ◽  
Ion Association ◽  
Resonance Rayleigh Scattering ◽  
Buffer Solution ◽  
Alizarin Red ◽  
Scattering Spectrum ◽  
Spectrum Characteristic

A new method for the determination of Gemifloxacin (GMFX) by using Resonance Rayleigh scattering was put forward. In HAc-NaAc buffer solution of pH 5 - 6, terbium (III) and antibiotics GMFX could form cationic complexes, which coulf further form 1 :2 : 1 (Tb3+ : GMFX :AR) ternary ion association complexes by the reaction with Alizarin Red (AR) anion through electrostatic and hydrophobic interaction. The new Resonance Rayleigh scattering (RRS) spectra would appear, and the two scattering peaks were located at 370nm and 590 nm. At 370 nm, the scattering enhancement (ΔI) was proportional to GMFX of certain concentration and its linear range and detection limit (3σ) were 0.005 ~ 4.00 μg.mL-1and 14.5 ng.mL-1. This method is simple, fast, with good selectivity and reproducibility, and it can be used for determination of GMFX drug in various body fluids.

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