scholarly journals The environment and disease: association or causation?

2020 ◽  
Vol 6 (2) ◽  
pp. 1-9
Author(s):  
Sir Austin Bradford Hill
Keyword(s):  
Disease Association

EHAI: Enhanced Human Microbe-Disease Association Identification

2020 ◽  
Vol 21 (11) ◽  
pp. 1078-1084
Author(s):  
Ruizhi Fan ◽  
Chenhua Dong ◽  
Hu Song ◽  
Yixin Xu ◽  
Linsen Shi ◽  
...  
Keyword(s):  
Microbial Community ◽  
Human Health ◽  
Complex Diseases ◽  
Disease Association ◽  
Computational Results ◽  
Computational Approaches ◽  
Disease Diagnostics ◽  
Disease Associations ◽  
Association Discovery ◽  
Biological Tool

: Recently, an increasing number of biological and clinical reports have demonstrated that imbalance of microbial community has the ability to play important roles among several complex diseases concerning human health. Having a good knowledge of discovering potential of microbe-disease relationships, which provides the ability to having a better understanding of some issues, including disease pathology, further boosts disease diagnostics and prognostics, has been taken into account. Nevertheless, a few computational approaches can meet the need of huge scale of microbe-disease association discovery. In this work, we proposed the EHAI model, which is Enhanced Human microbe- disease Association Identification. EHAI employed the microbe-disease associations, and then Gaussian interaction profile kernel similarity has been utilized to enhance the basic microbe-disease association. Actually, some known microbe-disease associations and a large amount of associations are still unavailable among the datasets. The ‘super-microbe’ and ‘super-disease’ were employed to enhance the model. Computational results demonstrated that such super-classes have the ability to be helpful to the performance of EHAI. Therefore, it is anticipated that EHAI can be treated as an important biological tool in this field.

scholarly journals VTRNA2-1: Genetic Variation, Heritable Methylation and Disease Association

2021 ◽  
Vol 22 (5) ◽  
pp. 2535
Author(s):  
Pierre-Antoine Dugué ◽  
Chenglong Yu ◽  
Timothy McKay ◽  
Ee Ming Wong ◽  
Jihoon Eric Joo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Genetic Variation ◽  
Genetic Factors ◽  
Disease Association ◽  
Country Of Birth ◽  
Cpg Site ◽  
Multiple Case ◽  
Metastable Epiallele ◽  
Methylation Quantitative Trait Loci

VTRNA2-1 is a metastable epiallele with accumulating evidence that methylation at this region is heritable, modifiable and associated with disease including risk and progression of cancer. This study investigated the influence of genetic variation and other factors such as age and adult lifestyle on blood DNA methylation in this region. We first sequenced the VTRNA2-1 gene region in multiple-case breast cancer families in which VTRNA2-1 methylation was identified as heritable and associated with breast cancer risk. Methylation quantitative trait loci (mQTL) were investigated using a prospective cohort study (4500 participants with genotyping and methylation data). The cis-mQTL analysis (334 variants ± 50 kb of the most heritable CpG site) identified 43 variants associated with VTRNA2-1 methylation (p < 1.5 × 10−4); however, these explained little of the methylation variation (R2 < 0.5% for each of these variants). No genetic variants elsewhere in the genome were found to strongly influence VTRNA2-1 methylation. SNP-based heritability estimates were consistent with the mQTL findings (h2 = 0, 95%CI: −0.14 to 0.14). We found no evidence that age, sex, country of birth, smoking, body mass index, alcohol consumption or diet influenced blood DNA methylation at VTRNA2-1. Genetic factors and adult lifestyle play a minimal role in explaining methylation variability at the heritable VTRNA2-1 cluster.

TAP 1 and TAP 2 transporter gene polymorphisms in multiple sclerosis: No evidence for disease association with TAP

1994 ◽  
Vol 54 (1-2) ◽  
pp. 35-40 ◽  
Author(s):  
Caroline Vandevyver ◽  
Piet Stinissen ◽  
Jean-Jacques Cassiman ◽  
Jef Raus
Keyword(s):  
Multiple Sclerosis ◽  
Gene Polymorphisms ◽  
Disease Association ◽  
Transporter Gene

scholarly journals Turning the Pump Handle: Evolving Methods for Integrating the Evidence on Gene-Disease Association

2007 ◽  
Vol 166 (8) ◽  
pp. 863-866 ◽  
Author(s):  
J. P. T. Higgins ◽  
J. Little ◽  
J. P. A. Ioannidis ◽  
M. S. Bray ◽  
T. A. Manolio ◽  
...  
Keyword(s):  
Disease Association

Late-onset thrombocytic microangiopathy caused by cblC disease: Association with a factor H mutation

2005 ◽  
Vol 45 (3) ◽  
pp. 588-595 ◽  
Author(s):  
Vincent Guigonis ◽  
Véronique Frémeaux-Bacchi ◽  
Stéphane Giraudier ◽  
Rémi Favier ◽  
Didier Borderie ◽  
...  
Keyword(s):  
Late Onset ◽  
Disease Association ◽  
Factor H ◽  
Factor H Mutation
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