Quantitative Trait Locus on Chromosome 12q14.1 Influences Variation in Plasma Plasminogen Levels in the San Antonio Family Heart Study

Human Biology ◽  
2007 ◽  
Vol 79 (5) ◽  
pp. 515-523 ◽  
Keyword(s):  
Quantitative Trait Locus ◽  
Quantitative Trait ◽  
San Antonio ◽  
Family Heart Study ◽  
Heart Study ◽  
Trait Locus

scholarly journals A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study

2010 ◽  
Vol 2010 ◽  
pp. 1-6
Author(s):  
V. P. Diego ◽  
L. Almasy ◽  
D. L. Rainwater ◽  
M. C. Mahaney ◽  
A. G. Comuzzie ◽  
...  
Keyword(s):  
Quantitative Trait ◽  
Mexican Americans ◽  
San Antonio ◽  
Lod Score ◽  
Family Heart Study ◽  
Heart Study ◽  
A Genome ◽  
Increased Risk ◽  
Chromosome 5P ◽  
D Dimer

Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD).Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS). The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery. D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (P≈.00001). In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM). We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM.Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.

scholarly journals Genome-Wide Scans Reveal Quantitative Trait Loci on 8p and 13q Related to Insulin Action and Glucose Metabolism: The San Antonio Family Heart Study

Diabetes ◽  
2004 ◽  
Vol 53 (5) ◽  
pp. 1369-1374 ◽  
Author(s):  
G. Cai ◽  
S. A. Cole ◽  
J. H. Freeland-Graves ◽  
J. W. MacCluer ◽  
J. Blangero ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Glucose Metabolism ◽  
Quantitative Trait ◽  
Insulin Action ◽  
San Antonio ◽  
Family Heart Study ◽  
Genome Wide ◽  
Heart Study ◽  
Trait Loci
Sign in / Sign up

Export Citation Format

Share Document