The Genetics of Obesity in Mexican Americans: The Evidence from Genome Scanning Efforts in the San Antonio Family Heart Study

Human Biology ◽  
2003 ◽  
Vol 75 (5) ◽  
pp. 635-646 ◽  
Author(s):  
Anthony G. Comuzzie ◽  
Bratxton D. Mitchell ◽  
Shelley Cole ◽  
Lisa J. Martin ◽  
Wen-Chi Hsueh ◽  
...  
Keyword(s):  
Mexican Americans ◽  
San Antonio ◽  
Genome Scanning ◽  
Family Heart Study ◽  
Heart Study ◽  
Genetics Of Obesity

scholarly journals A Quantitative Trait Locus on Chromosome 5p Influences D-Dimer Levels in the San Antonio Family Heart Study

2010 ◽  
Vol 2010 ◽  
pp. 1-6
Author(s):  
V. P. Diego ◽  
L. Almasy ◽  
D. L. Rainwater ◽  
M. C. Mahaney ◽  
A. G. Comuzzie ◽  
...  
Keyword(s):  
Quantitative Trait ◽  
Mexican Americans ◽  
San Antonio ◽  
Lod Score ◽  
Family Heart Study ◽  
Heart Study ◽  
A Genome ◽  
Increased Risk ◽  
Chromosome 5P ◽  
D Dimer

Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD).Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS). The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery. D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (P≈.00001). In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM). We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM.Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.

scholarly journals Genome-wide scans for microalbuminuria in Mexican Americans: The San Antonio Family Heart Study

2007 ◽  
Vol 9 (2) ◽  
pp. 80-87 ◽  
Author(s):  
Nedal Arar ◽  
Subrata Nath ◽  
Farook Thameem ◽  
Richard Bauer ◽  
Saroja Voruganti ◽  
...  
Keyword(s):  
Mexican Americans ◽  
San Antonio ◽  
Family Heart Study ◽  
Genome Wide ◽  
Heart Study

Principal Component for Metabolic Syndrome Risk Maps to Chromosome 4p in Mexican Americans: The San Antonio Family Heart Study

Human Biology ◽  
2004 ◽  
Vol 76 (5) ◽  
pp. 651-665 ◽  
Author(s):  
Guowen Cai ◽  
Shelley A. Cole ◽  
Jeanne H. Freeland-Graves ◽  
Jean W. MacCluer ◽  
John Blangero ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Mexican Americans ◽  
San Antonio ◽  
Principal Component ◽  
Family Heart Study ◽  
Heart Study ◽  
Risk Maps

Heritability of Commonly Measured Blood Cell Phenotypes in the San Antonio Family Heart Study.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 3687-3687
Author(s):  
Kevin R. Viel ◽  
Tom Howard ◽  
Joanne E. Curran ◽  
Laura Almasy ◽  
Eric K. Moses ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
San Antonio ◽  
Genetic Influence ◽  
Blood Cell Count ◽  
Distribution Width ◽  
Family Heart Study ◽  
Heart Study ◽  
The Mean ◽  
Cell Phenotypes

Abstract Heritability (h2) indicates the extent to which genes contribute to the observed inter-individual variation in a phenotype. Traits that have a high h2 may be fruitful targets of a subsequent genome screen to identify quantitative trait loci (QTL) and the genetic variants underlying them. We have estimated the heritabilities of measurements that commonly comprise a complete blood cell count (CBC) for members of the San Antonio Family Heart Study (table). The number of white blood cells per μL of blood (WBC) was not under genetic influence (h2 = 0.160, p = 0.253), however, the individual components of the differential (lymphocyte, monocyte, and granulocyte percentage) did appear to be. Red blood cell count (RBC) had the highest heritability (h2 = 0.638, p < 0.001) with both the mean corpuscular volume (MCV) and the red cell distribution width (RDW) demonstrating moderate heritability. The platelet count (Plt) and the mean platelet volume (MPV) had a mild genetic influence that was nominally significant. Currently, the fourth longitudinal examination of this cohort is in progress and to date we have measurements for 154 Mexican American subjects in 16 nuclear families. If prior recruitment rate is maintained, bivariate analyses assessing pleiotropy between traits may be available for presentation. Some of these traits have been investigated previously, but for many these are the first reported h2 estimates to our knowledge. This investigation is a necessary first step to understanding the contributions of genes to these important clinical measurements and to the elucidation of the biological pathways involved in their regulation, which may lead to improved diagnostics and therapies to treat blood cell-related disorders. Heritabilities of commonly measured blood cell phenotypes Phenotype h2 (p-value) 1 Inverse normal transformed value WBC 0.163 (0.253) LY (%) 0.599 (<0.001) MO (%) 0.603 (0.011) GR (%) 0.500 (0.004) RBC 0.638 (<0.001) Hgb 0.283 (0.094) Hct 0.432 (0.023) MCV 0.476 (0.005) MCH 0.429 (0.011) MCHC1 0.249 (0.139) RDW1 0.422 (0.014) Plt 0.290 (0.013) MPV 0.298 (0.006)

Dietary intakes of essential nutrients among Mexican-Americans and Anglo-Americans: the San Antonio Heart Study

1985 ◽  
Vol 42 (2) ◽  
pp. 307-316 ◽  
Author(s):  
J A Knapp ◽  
S M Haffner ◽  
E A Young ◽  
H P Hazuda ◽  
L Gardner ◽  
...  
Keyword(s):  
Mexican Americans ◽  
San Antonio ◽  
Dietary Intakes ◽  
Essential Nutrients ◽  
Heart Study

No Evidence of Cis-Acting SNPs In Immune Response Genes Previously Associated with Factor VIII Inhibitors: The San Antonio Family Heart Study

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4422-4422
Author(s):  
Tom E. Howard ◽  
Kevin R. Viel ◽  
Eugene Drigalenko ◽  
Shelley Cole ◽  
Melinda Epstein ◽  
...  
Keyword(s):  
Immune Response ◽  
San Antonio ◽  
Expression Profiles ◽  
Mrna Levels ◽  
Promoter Polymorphisms ◽  
Cis Acting ◽  
Immune Response Genes ◽  
Functional Variants ◽  
Family Heart Study ◽  
Heart Study

Abstract Abstract 4422 Background/Aims: FVIII gene (F8) mutation type is a risk factor for FVIII inhibitors, which develop in ~20-30% of hemophilia A patients following FVIII replacement therapy. Studies have investigated immune response genes to determine why FVIII is immunogenic in some, but not all, patients with the same F8 abnormality. While some studies have found associations between inhibitor status and promoter polymorphisms in CTLA4, TNFA, and/or IL10, others have not. If these promoter polymorphisms influence inhibitor development, their alleles could modulate transcription initiation rates. The goal of this study was to investigate cis-acting genotype-specific differences in mean steady state mRNA levels. Method: We examined the relationship of lymphocyte CTLA4, TNFA, and IL10 mRNA levels with the genotypes of 49 SNPs located across their structural loci in 1189 Mexican American participants of the San Antonio Family Heart Study (SAFHS). Expression profiles were generated using Illumina's HWG-6 BeadChips and genotypes came from the Illumina Human HapMap 550 SNP panel. Measured genotype association analyses that accounted for non-independence of family members and employed an additive model were performed using the software package SOLAR. Result: Except for C(-13780)A, located upstream of CTLA4, which was modestly associated with CTLA4 mRNA levels (p<0.005), we observed no cis-acting regulatory variants associated with these genes’ transcription levels. Conclusion: We observed little evidence for cis-regulation of CTLA4, TNFA, and IL10 in Mexican Americans. It is possible that cis-acting functional variants are rare and not well-represented by the common GWAS SNPs used for these analyses. Because previously implicated polymorphisms were not included in this analysis and linkage disequilibrium patterns between markers are population-specific, we are currently genotyping these SNPs in the SAFHS. Disclosures: No relevant conflicts of interest to declare.

Sign in / Sign up

Export Citation Format

Share Document