The Affordable Care Act and Genetic Testing for Inheritable Cancer Syndromes: Impact on High-Risk Underserved Minorities

2014 ◽  
Vol 25 (1A) ◽  
pp. 46-62 ◽  
Author(s):  
Farzana L. Walcott ◽  
Barbara K. Dunn ◽  
Mary DeShields ◽  
Claudia Baquet
Keyword(s):  
Genetic Testing ◽  
High Risk ◽  
Affordable Care Act ◽  
The Affordable Care Act ◽  
Underserved Minorities ◽  
Cancer Syndromes

scholarly journals NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 1.2020

2020 ◽  
Vol 18 (4) ◽  
pp. 380-391 ◽  
Author(s):  
Mary B. Daly ◽  
Robert Pilarski ◽  
Matthew B. Yurgelun ◽  
Michael P. Berry ◽  
Saundra S. Buys ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Genetic Testing ◽  
High Risk ◽  
Nccn Guidelines ◽  
Therapy Decision ◽  
Increased Risk ◽  
Management Recommendations ◽  
Cancer Syndromes ◽  
Familial High Risk ◽  
Testing And Counseling

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic provide recommendations for genetic testing and counseling for hereditary cancer syndromes, and risk management recommendations for patients who are diagnosed with syndromes associated with an increased risk of these cancers. The NCCN panel meets at least annually to review comments, examine relevant new data, and reevaluate and update recommendations. These NCCN Guidelines Insights summarize the panel’s discussion and most recent recommendations regarding criteria for high-penetrance genes associated with breast and ovarian cancer beyond BRCA1/2, pancreas screening and genes associated with pancreatic cancer, genetic testing for the purpose of systemic therapy decision-making, and testing for people with Ashkenazi Jewish ancestry.

Adult cancer survivorship referrals for hereditary cancer genetic testing.

2018 ◽  
Vol 36 (7_suppl) ◽  
pp. 183-183
Author(s):  
Farzana L. Walcott ◽  
Rebecca Davidson Kaltman ◽  
Elizabeth Hatcher ◽  
Cam Ha ◽  
Tara Biagi ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Family History ◽  
High Risk ◽  
Cancer Survivorship ◽  
Nurse Practitioner ◽  
Hereditary Cancer ◽  
Hereditary Cancer Syndromes ◽  
History Of ◽  
Cancer Syndromes ◽  
History Of Cancer

183 Background: Genetic testing for hereditary cancer syndromes is underutilized among cancer patients. Cancer survivorship clinics may identify individuals at risk for hereditary cancer. We present the number of referrals from George Washington (GW) Adult Cancer Survivorship Clinic (ACS) to the GW Ruth Paul Hereditary Cancer Program (RPHCP) to demonstrate the feasibility of identifying high risk individuals in cancer survivorship. Methods: We reviewed the number of patients seen at the GW ACS and subsequent referrals to the GW RPHCP for genetic counseling/testing. An IRB approved research registry was used for retrieval of the data. The ACS clinic is staffed by a physician internist trained in clinical cancer genetics and a nurse practitioner trained in cancer survivorship. Results: 261 patients were seen in ACS from January 1, 2016, to September 30, 2017. Twenty patients (7.6%) were referred to RPHCP based on personal/family cancer history. Three patients were not consented for the research registry, leaving a total of 17 patients for this analysis. Fifteen (88.2%) patients were referred by the physician and 2/17 (11.7%) were referred by the nurse practitioner. Sixteen patients had genetic testing (94.1%) and results were: 5/16 (31.2%) positive, 6/16 (37.5%) negative, and 3/16 (18.7%) had a variant of unknown significance (VUS). Results on 2 patients are pending. One patient deferred testing. Of the 17 patients referred, 14/17 (82.3%) had personal/family history of cancer and had seen an oncologist. Cancer sites and germline mutations identified were: bilateral breast cancer and bladder cancer (BRCA2), prostate cancer (MUTYH), breast and ovarian cancer (BRCA1), endometrial cancer (APC). One patient without cancer was referred by an oncologist for a previously identified familial MLH1 mutation, and was positive. Conclusions: Cancer survivorship clinics may identify individuals appropriate for genetic testing for hereditary cancer syndromes. This is likely an underestimate as not all cancer patients are seen in survivorship clinic. Systematic capture of personal and family history of cancer in cancer survivors may enhance utilization of genetic testing services among cancer survivors and identification of high risk individuals.

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