scholarly journals Syphilization and Its Discontents: Experimental Inoculation against Syphilis at the London Lock Hospital

2017 ◽  
Vol 91 (1) ◽  
pp. 1-32 ◽  
Author(s):  
Anne Hanley
Keyword(s):  
Experimental Inoculation ◽  
Lock Hospital

Salmonella Persistence within the Peripheral Lymph Nodes of Cattle following Experimental Inoculation

2016 ◽  
Vol 79 (6) ◽  
pp. 1032-1035 ◽  
Author(s):  
T. S. EDRINGTON ◽  
G. H. LONERAGAN ◽  
K. J. GENOVESE ◽  
D. L. HANSON ◽  
D. J. NISBET
Keyword(s):  
Body Weight ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Enrichment Culture ◽  
Lower Leg ◽  
Challenge Strain ◽  
Peripheral Lymph ◽  
Experimental Inoculation ◽  
Duration Of Infection

ABSTRACT Utilizing a transdermal method of inoculation developed in our laboratory, the duration of infection of Salmonella in the peripheral lymph nodes of steers was examined. Thirty-six Holstein steers (mean body weight of 137 kg) were inoculated with Salmonella Montevideo (day 0) on each lower leg and both sides of the back and abdomen. Calves were euthanized beginning at 6 h and subsequently on each of days 1, 2, 4, 7, 9, 11, 14, and 21 postinoculation (four animals each time). The subiliac, popliteal, and superficial cervical (prescapular) lymph nodes were collected and cultured (quantitatively and qualitatively) for the challenge strain of Salmonella. The challenge strain was detected via direct culture within the lymph nodes at 6 h postinoculation and on each subsequent necropsy date. Salmonella levels in lymph node were 0.8 to 1.8 log CFU/g. Lymph nodes were generally positive after enrichment culture throughout the experiment. Salmonella elimination appeared to begin approximately 14 days postinoculation. However, elimination was not completed by day 21; therefore, a second experiment was conducted identical to the first except that the time from inoculation to necropsy was extended. Salmonella was recovered via direct culture on each of the necropsy days, and results in general were similar to those of experiment I, except that on days 20, 24, and 28 isolates from serogroups C2 and E1 were identified in addition to the inoculation strain C1 in multiple animals. The data from both experiments indicate that after a single inoculation event, Salmonella would be completely cleared by approximately 28 days. Further research with expanded times between inoculation and necropsy is required for verification.

scholarly journals Clinical Records of the Lock Hospital

BMJ ◽  
1861 ◽  
Vol 1 (21) ◽  
pp. 543-545
Author(s):  
H. Lee
Keyword(s):  
Clinical Records ◽  
Lock Hospital

London Lock Hospital

BMJ ◽  
1949 ◽  
Vol 1 (4615) ◽  
pp. 1096-1096
Author(s):  
G. M. Sandes
Keyword(s):  
Lock Hospital

scholarly journals Phenotypic characterisation of the cellular immune infiltrate in placentas of cattle following experimental inoculation with Neospora caninum in late gestation

2013 ◽  
Vol 44 (1) ◽  
pp. 60 ◽  
Author(s):  
Germán J Cantón ◽  
Frank Katzer ◽  
Julio Benavides-Silván ◽  
Stephen W Maley ◽  
Javier Palarea-Albaladejo ◽  
...  
Keyword(s):  
Neospora Caninum ◽  
Late Gestation ◽  
Immune Infiltrate ◽  
Phenotypic Characterisation ◽  
Experimental Inoculation ◽  
Cellular Immune

Neospora caninum (Protozoa: Apicomplexa) infections in rats

1990 ◽  
Vol 68 (7) ◽  
pp. 1595-1599 ◽  
Author(s):  
David S. Lindsay ◽  
J. P. Dubey
Keyword(s):  
Rattus Norvegicus ◽  
Neospora Caninum ◽  
Clinical Signs ◽  
Hepatic Necrosis ◽  
Female Rats ◽  
Methylprednisolone Acetate ◽  
Laboratory Rats ◽  
Experimental Inoculation ◽  
Caninum Tachyzoites ◽  
Subcutaneous Inoculation

The susceptibility of laboratory rats (Rattus norvegicus) to experimental inoculation with tachyzoites of Neospora caninum was examined. Groups of female rats were intramuscularly injected with 0, 2, or 4 mg of methylprednisolone acetate (MPA) 7 days prior to, and on the day of, subcutaneous inoculation with 0 or 1.5 × 105 tachyzoites. Clinical signs of disease or deaths did not occur in rats given nothing or only N. caninum tachyzoites. Rats given only 4 mg MPA failed to grow as well as rats given nothing or only N. caninum tachyzoites but were otherwise healthy. All of 20 rats given 4 mg MPA and tachyzoites died of hepatitis and pneumonia within 12 days postinoculation. Hepatic necrosis was the most striking lesion seen in these rats, and other milder lesions consisted of pneumonia, encephalitis, and myositis. The response of rats given 2 mg MPA and tachyzoites was less severe. Three of 20 rats died with encephalitis, myositis, hepatitis, and pancreatitis. Mild lesions, but no N. caninum tachyzoites, were seen in 3 of 14 rats inoculated only with tachyzoites. Rats given the 4 mg MPA treatment and inoculated with N. caninum tachyzoites appear to be suitable subjects for examining acute neosporosis and could be used in studies designed to examine treatment of acute disease.

scholarly journals The role of wild ruminants in the epidemiology of bovine petechial fever

1975 ◽  
Vol 74 (2) ◽  
pp. 245-250 ◽  
Author(s):  
D. R. Snodgrass ◽  
L. H. Karstad ◽  
J. E. Cooper
Keyword(s):  
Clinical Findings ◽  
Wild Ruminants ◽  
Experimental Inoculation

SUMMARYAfter experimental inoculation of Cytoecetes ondiri, the agent of bovine petechial fever (BPF), multiplication occurred in impala, bushbuck, Thomson's gazelles and wildebeest, as shown by infectivity studies and clinical findings. Similar attempts to infect one eland failed.As a sequel to this, blood and spleen samples were collected from four species of wild ruminants in an area where BPF was endemic. Isolations of C. ondiri were made from three of five bushbuck, but not from any other species.

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