Emil von Behring: Infectious Disease, Immunology, Serum Therapy (review)

Bernard (after Ber. . D. G. Gyn.) Finds that the treatment of the above diseases with a vaccine can only be applied in mild chronic and subacute cases, when the body is still capable of producing sufficient antibodies. In severe acute streptococcal infection, the body is already saturated with the vaccine, therefore, its introduction from the outside only worsens the condition of patients. The autovaccine gives the best results, but it takes time to prepare it, which cannot be wasted in acute cases. It is possible to judge the effect of antistreptococcal serum only by the outcome of severe diseases, mild cases proceed well with other interventions. Bumm is an ardent supporter of anti-streptococcal serum therapy, as treatment with the latter gave him only 6.9% mortality. The author considers serum sickness as a good sign indicating the body's ability to react. Serum treatment should be initiated from the onset of the disease. Morgenroth tries to explain the good outcome of early intervention by the fact that at the beginning of the disease, streptococcus easily loses its virulent properties and ability to emolysis, but after a few days it can regain them; therefore, the time of treatment is important for the outcome of the disease, when the pathogen does not yet possess high virulence with sufficient resistance of the organism. It is necessary in each case of an infectious disease to immediately inject antistreptococcal serum, without waiting for the results of bacteriological research.

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Emil von Behring and serum therapy

Microbes and Infection ◽

10.1016/s1286-4579(01)01526-x ◽

2002 ◽

Vol 4 (2) ◽

pp. 185-188 ◽

Cited By ~ 40

Author(s):

Florian Winau ◽

Rolf Winau

Keyword(s):

Serum Therapy ◽

Emil Von Behring

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Tissue section lifting for electron microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100081292 ◽

1978 ◽

Vol 36 (2) ◽

pp. 86-87

Author(s):

Adrian F. van Dellen

Keyword(s):

Infectious Disease ◽

Electron Microscopy ◽

Tissue Culture ◽

Organ System ◽

Surrounding Tissue ◽

Paraffin Sections ◽

Surface Areas ◽

Specific Determination ◽

High Degree ◽

Accuracy And Repeatability

The morphologic pathologist may require information on the ultrastructure of a non-specific lesion seen under the light microscope before he can make a specific determination. Such lesions, when caused by infectious disease agents, may be sparsely distributed in any organ system. Tissue culture systems, too, may only have widely dispersed foci suitable for ultrastructural study. In these situations, when only a few, small foci in large tissue areas are useful for electron microscopy, it is advantageous to employ a methodology which rapidly selects a single tissue focus that is expected to yield beneficial ultrastructural data from amongst the surrounding tissue. This is in essence what "LIFTING" accomplishes. We have developed LIFTING to a high degree of accuracy and repeatability utilizing the Microlift (Fig 1), and have successfully applied it to tissue culture monolayers, histologic paraffin sections, and tissue blocks with large surface areas that had been initially fixed for either light or electron microscopy.

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