Advancing the testing and assessment of chemical substances for endocrine disruption: OECD activities

2003 ◽  
Vol 75 (11-12) ◽  
pp. 2613-2615
Author(s):  
H. B. W. M. Koëter
Keyword(s):  
Human Health ◽  
Endocrine Disruption ◽  
Endocrine Disrupting Chemicals ◽  
Test Methods ◽  
Chemical Substances ◽  
Work Sharing ◽  
Work Related ◽  
Testing Tools ◽  
Endocrine Disrupting ◽  
Development And Validation

This paper describes the establishment of a number of expert groups in the Organization for Economic Cooperation and Development (OECD) to manage the work related to the development and validation of test methods to identify and characterize the human health and aquatic environmental hazards of endocrine-disrupting chemicals. In addition, the concept of testing and assessment, using the most adequate testing tools without being prescriptive, is explained, and a coordinated approach for international work sharing under the OECD umbrella is described.

Hormonal Confusion

2016 ◽  
Author(s):  
Geoffrey C. Kabat
Keyword(s):  
European Union ◽  
Hormone Therapy ◽  
Human Health ◽  
Endocrine Disruption ◽  
Endocrine Disrupting Chemicals ◽  
Environmental Exposures ◽  
Environmental Estrogens ◽  
The European Union ◽  
Endocrine Disrupting

In the early 1990s concern emerged that hormonal compounds present in small amounts in food and water – “environmental estrogens” -- could be having subtle effects on human health and wildlife. This concern led to the formulation of the “endocrine-disruption hypothesis,” which has received widespread attention. Over twenty years of research have shown that environmental exposures to these substances is generally minute and are dwarfed by hormonal (phytoestrogenic) compounds in food, as well as by hormone therapy used by some women. Nevertheless, the issue of “endocrine-disrupting chemicals in the environment” is currently under debate within the European Union and elsewhere.

scholarly journals Endocrine disrupting chemicals: harmful substances and how to test them

2002 ◽  
Vol 18 (2) ◽  
pp. 489-494 ◽  
Author(s):  
Nicolás Olea-Serrano ◽  
Mariana F. Fernández-Cabrera ◽  
Rosa Pulgar-Encinas ◽  
Fátima Olea-Serrano
Keyword(s):  
Endocrine Disruptors ◽  
Endocrine Disruption ◽  
Endocrine Disrupting Chemicals ◽  
Chemical Substances ◽  
Dose Time ◽  
Governmental Organizations ◽  
Non Governmental Organizations ◽  
Endocrine Disrupting ◽  
Regulatory Bodies ◽  
Estimation Of Risk

This paper presents an analysis of the opinions of different groups from: scientists, international regulatory bodies, non-governmental organizations and industry; with an interest in the problem of identifying chemical substances with endocrine disrupting activity. There is also discussion of the consequences that exposure to endocrine disruptors may have for human health, considering concrete issues related to: the estimation of risk; the tests that must be used to detect endocrine disruption; the difficulties to establish an association between dose, time of exposure, individual susceptibility, and effect; and the attempts to create a census of endocrine disruptors. Finally, it is proposed that not all hormonal mimics should be included under the single generic denomination of endocrine disruptors.

scholarly journals Environmental Obesogens and Human Health

2021 ◽  
Author(s):  
Archisman Mahapatra ◽  
Priya Gupta ◽  
Anjali Suman ◽  
Rahul Kumar Singh
Keyword(s):  
Human Health ◽  
Endocrine Disruption ◽  
Adult Population ◽  
Endocrine Disrupting Chemicals ◽  
Model Systems ◽  
Health Concern ◽  
Increased Risk ◽  
Endocrine Disrupting ◽  
The World ◽  
Underlying Mechanisms

Obesity is an alarming public health concern that contributes to a substantially increased risk of multiple chronic disorders, including diabetes. As per WHO data, in 2016, almost 39% adult population of the world is overweight, 13% of them were obese. There is prominent evidence on the involvement of environmental endocrine-disrupting chemicals, termed obesogens, in the prevalence of this growing worldwide pandemic, obesity. The exaggerated effect of obesogens on endocrine disruption, lipid metabolism and homeostasis, adipocyte functioning, impaired thermogenesis, inflammation, epigenetics, and overall human health will be covered in this chapter. This chapter will discuss the environmental obesogen hypothesis, the epidemiological and experimental evidence of obesogens, its chemical characteristics, and possible mechanism of actions. It will also focus on some recent indications of obesogens and their correlation in COVID-19 disease pathogenesis. This chapter will try to conclude with strategies for identifying the underlying mechanisms of obesogens within model systems and the human body, including future directions.

scholarly journals Epigenetics, Evolution, Endocrine Disruption, Health, and Disease

Endocrinology ◽  
2006 ◽  
Vol 147 (6) ◽  
pp. s4-s10 ◽  
Author(s):  
David Crews ◽  
John A. McLachlan
Keyword(s):  
Mental Health ◽  
Recent Work ◽  
Endocrine Disruption ◽  
Endocrine Disrupting Chemicals ◽  
Epigenetic Mechanisms ◽  
Physical And Mental Health ◽  
Risk Levels ◽  
Endocrine Disrupting ◽  
Increase Risk ◽  
Health And Disease

Abstract Endocrine-disrupting chemicals (EDCs) in the environment have been linked to human health and disease. This is particularly evident in compounds that mimic the effects of estrogens. Exposure to EDCs early in life can increase risk levels of compromised physical and mental health. Epigenetic mechanisms have been implicated in this process. Transgenerational consequences of EDC exposure is also discussed in both a proximate (mechanism) and ultimate (evolution) context as well as recent work suggesting how such transmission might become incorporated into the genome and subject to selection. We suggest a perspective for exploring and ultimately coming to understand diseases that may have environmental or endocrine origins.

scholarly journals Epidemiological Approaches to the Effects of Endocrine Disrupting Chemicals on Human Health

2000 ◽  
Vol 21 (6) ◽  
pp. 361-367 ◽  
Author(s):  
MASAHARU YAMAMOTO ◽  
HIROTO NAKADAIRA ◽  
KAZUTOSHI NAKAMURA ◽  
KAZUO ENDOH
Keyword(s):  
Human Health ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting

Biomarkers as Diagnostic and Prognostic Tools for Wildlife Risk Assessment: Integrating Endocrine-Disrupting Chemicals

1998 ◽  
Vol 14 (1-2) ◽  
pp. 291-309 ◽  
Author(s):  
Maria Cristina Fossi
Keyword(s):  
Risk Assessment ◽  
Theoretical Basis ◽  
Endocrine Disrupting Chemicals ◽  
The State ◽  
Endocrine Disrupting ◽  
Development And Validation ◽  
State Of Art

The state of art of the biomarker approach in ecotoxicology is reviewed with particular reference to its use in the assessment of exposure to endocrine-disrupting chemicals in wildlife. The following topics are discussed: the theoretical basis of the biomarker approach; the advantages of biomarker strategies in biomonitoring programs; application of biomarker strategies in an ecotoxicological context; the main biomarker techniques; interpretation of the results; and the development and validation of nondestructive biomarkers.

Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior

2020 ◽  
Vol 82 (1) ◽  
pp. 177-202 ◽  
Author(s):  
Dinushan Nesan ◽  
Deborah M. Kurrasch
Keyword(s):  
Endocrine Disruption ◽  
Polybrominated Diphenyl Ethers ◽  
Animal Studies ◽  
Endocrine Disrupting Chemicals ◽  
Lactational Exposure ◽  
Gestational Exposure ◽  
Early Life Exposure ◽  
Endocrine Disrupting ◽  
Physiological Homeostasis ◽  
Nervous System Function

Endocrine disrupting chemicals are common in our environment and act on hormone systems and signaling pathways to alter physiological homeostasis. Gestational exposure can disrupt developmental programs, permanently altering tissues with impacts lasting into adulthood. The brain is a critical target for developmental endocrine disruption, resulting in altered neuroendocrine control of hormonal signaling, altered neurotransmitter control of nervous system function, and fundamental changes in behaviors such as learning, memory, and social interactions. Human cohort studies reveal correlations between maternal/fetal exposure to endocrine disruptors and incidence of neurodevelopmental disorders. Here, we summarize the major literature findings of endocrine disruption of neurodevelopment and concomitant changes in behavior by four major endocrine disruptor classes:bisphenol A, polychlorinated biphenyls, organophosphates, and polybrominated diphenyl ethers. We specifically review studies of gestational and/or lactational exposure to understand the effects of early life exposure to these compounds and summarize animal studies that help explain human correlative data.

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