Effects of endocrine disruptors in aquatic mammals

2003 ◽  
Vol 75 (11-12) ◽  
pp. 2235-2247 ◽  
Author(s):  
M. C. Fossi ◽  
Letizia Marsili
Keyword(s):  
Endocrine Disruptors ◽  
Food Chain ◽  
State Of The Art ◽  
Endocrine Disrupting Chemicals ◽  
Future Research ◽  
Toxicological Effects ◽  
Aquatic Food Chain ◽  
Endocrine Disrupting ◽  
Aquatic Food ◽  
Aquatic Mammals

In the last few decades, various studies have shown that aquatic mammals are sensitive to the toxicological effects of certain xenobiotic compounds, including the large class of endocrine-disrupting chemicals (EDCs). Since some EDCs, particularly organochlorines, tend to bioaccumulate and biomagnify in the aquatic food chain, various aquatic mammals, particularly those high in the food chain, such as pinnipeds, odontocete cetaceans, and polar bears, are potentially "at risk". The main aim of this chapter is to define the state of the art on effects of endocrine disruptors in aquatic mammals, both freshwater and marine. Another aim is to formulate recommendations for future research in this field and finally to define what can be done internationally for hazard/risk assessment and communication of the findings.

scholarly journals Endocrine Disrupting Chemicals: Current Understanding, New Testing Strategies and Future Research Needs

2021 ◽  
Vol 22 (2) ◽  
pp. 933
Author(s):  
Maria E. Street ◽  
Karine Audouze ◽  
Juliette Legler ◽  
Hideko Sone ◽  
Paola Palanza
Keyword(s):  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Current Understanding ◽  
Future Research ◽  
Developmental Origins ◽  
Research Needs ◽  
Important Class ◽  
Testing Strategies ◽  
Endocrine Disrupting ◽  
Health And Disease

Endocrine disrupting chemicals (EDCs) are exogenous chemicals which can disrupt any action of the endocrine system, and are an important class of substances which play a role in the Developmental Origins of Health and Disease (DOHaD) [...]

scholarly journals Endocrine Disrupting Chemicals and Thyroid Cancer: An Overview

Toxics ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 14
Author(s):  
Mathilda Alsen ◽  
Catherine Sinclair ◽  
Peter Cooke ◽  
Kimia Ziadkhanpour ◽  
Eric Genden ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Flame Retardants ◽  
Endocrine Disrupting Chemicals ◽  
National Institutes Of Health ◽  
Future Research ◽  
National Library ◽  
Comprehensive Overview ◽  
Carcinogenic Effect ◽  
Increased Risk ◽  
Endocrine Disrupting

Endocrine disruptive chemicals (EDC) are known to alter thyroid function and have been associated with increased risk of certain cancers. The present study aims to provide a comprehensive overview of available studies on the association between EDC exposure and thyroid cancer. Relevant studies were identified via a literature search in the National Library of Medicine and National Institutes of Health PubMed as well as a review of reference lists of all retrieved articles and of previously published relevant reviews. Overall, the current literature suggests that exposure to certain congeners of flame retardants, polychlorinated biphenyls (PCBs), and phthalates as well as certain pesticides may potentially be associated with an increased risk of thyroid cancer. However, future research is urgently needed to evaluate the different EDCs and their potential carcinogenic effect on the thyroid gland in humans as most EDCs have been studied sporadically and results are not consistent.

scholarly journals Experimental aquatic food chain system: Enhancing Daphnia magna as natural feed using eutrophic waters

2020 ◽  
Vol 535 ◽  
pp. 012052
Author(s):  
L R Tanjung ◽  
T Chrismadha ◽  
Y Mardiati ◽  
Sutrisno ◽  
E Mulyana ◽  
...  
Keyword(s):  
Daphnia Magna ◽  
Food Chain ◽  
Chain System ◽  
Aquatic Food Chain ◽  
Aquatic Food

scholarly journals Epigenetic modifications associated with in utero exposure to endocrine disrupting chemicals BPA, DDT and Pb

2019 ◽  
Vol 34 (4) ◽  
pp. 309-325 ◽  
Author(s):  
Chinonye Doris Onuzulu ◽  
Oluwakemi Anuoluwapo Rotimi ◽  
Solomon Oladapo Rotimi
Keyword(s):  
Endocrine Disruptors ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine System ◽  
Environmental Chemicals ◽  
Epigenetic Mechanisms ◽  
Epigenetic Alterations ◽  
Endocrine Disrupting ◽  
Non Coding Rnas ◽  
Hormone System ◽  
Developmental Windows

Abstract Endocrine disrupting chemicals (EDCs) are xenobiotics which adversely modify the hormone system. The endocrine system is most vulnerable to assaults by endocrine disruptors during the prenatal and early development window, and effects may persist into adulthood and across generations. The prenatal stage is a period of vulnerability to environmental chemicals because the epigenome is usually reprogrammed during this period. Bisphenol A (BPA), lead (Pb), and dichlorodiphenyltrichloroethane (DDT) were chosen for critical review because they have become serious public health concerns globally, especially in Africa where they are widely used without any regulation. In this review, we introduce EDCs and describe the various modes of action of EDCs and the importance of the prenatal and developmental windows to EDC exposure. We give a brief overview of epigenetics and describe the various epigenetic mechanisms: DNA methylation, histone modifications and non-coding RNAs, and how each of them affects gene expression. We then summarize findings from previous studies on the effects of prenatal exposure to the endocrine disruptors BPA, Pb and DDT on each of the previously described epigenetic mechanisms. We also discuss how the epigenetic alterations caused by these EDCs may be related to disease processes.

scholarly journals Effects of endocrine disruptors in the development of the female reproductive tract

2014 ◽  
Vol 58 (2) ◽  
pp. 153-161 ◽  
Author(s):  
Elaine Maria Frade Costa ◽  
Poli Mara Spritzer ◽  
Alexandre Hohl ◽  
Tânia A. S. S. Bachega
Keyword(s):  
Endocrine Disruptors ◽  
Hormone Receptors ◽  
Reproductive Tract ◽  
Polycystic Ovary ◽  
Endocrine Disrupting Chemicals ◽  
Public Health Problem ◽  
Female Reproductive Tract ◽  
Major Public Health Problem ◽  
Endocrine Disrupting ◽  
Environmental Agencies

Environmental agencies have identified a growing number of environmental contaminants that have endocrine disrupting activity, and these can become a major public health problem. It is suggested that endocrine disruptors could account for the higher-than-expected increase in the prevalence of some non-communicable diseases, such as obesity, diabetes, thyroid diseases, and some cancers. Several endocrine Disrupting Chemicals (EDCs), such as pesticides, bisphenol A, phthalates, dioxins, and phytoestrogens, can interact with the female reproductive system and lead to endocrine disruption. Initially, it was assumed that EDCs exert their effects by binding to hormone receptors and transcription factors, but it is currently known that they may also alter the expression of enzymes involved in the synthesis or catabolism of steroids. Biomonitoring studies have identified these compounds in adults, children, pregnant women, and fetuses. Among the diseases of the female reproductive tract associated with EDCs exposure are the following: precocious puberty, polycystic ovary syndrome, and premature ovarian failure. The different populations of the world are exposed to a great number of chemicals through different routes of infection; despite the various available studies, there is still much doubt regarding the additive effect of a mixture of EDCs with similar mechanisms of action.

scholarly journals Inuit Exposure to Organochlorines through the Aquatic Food Chain in Arctic Quebec

1993 ◽  
Vol 101 (7) ◽  
pp. 618 ◽  
Author(s):  
Eric Dewailly ◽  
Pierre Ayotte ◽  
Suzanne Bruneau ◽  
Claire Laliberte ◽  
Derek C. G. Muir ◽  
...  
Keyword(s):  
Food Chain ◽  
Aquatic Food Chain ◽  
Aquatic Food

The Dynamics of Tritium - Including OBT - in the Aquatic Food Chain

2005 ◽  
Vol 48 (1) ◽  
pp. 779-782 ◽  
Author(s):  
D. Galeriu ◽  
R. Heling ◽  
A. Melintescu
Keyword(s):  
Food Chain ◽  
Aquatic Food Chain ◽  
Aquatic Food
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