On the molecular origin of the protein catalysis of the primary process in bacteriorhodopsin photosynthesis: Retinal photoisomerization

1997 ◽  
Vol 69 (4) ◽  
pp. 749-754 ◽  
Author(s):  
Mostafa A. El-Sayed ◽  
S. Logunov
Keyword(s):  
Primary Process ◽  
Molecular Origin ◽  
Protein Catalysis

Review of the Radiation Damage Problem of Organic Specimens in Electron Microscopy

1973 ◽  
Vol 31 ◽  
pp. 476-477
Author(s):  
L. Reimer
Keyword(s):  
Electron Microscopy ◽  
Radiation Damage ◽  
Irradiation Time ◽  
Dose Effect ◽  
Primary Process ◽  
Thin Specimen ◽  
Secondary Damage ◽  
Small Doses ◽  
Micro Organisms ◽  
Damage Processes

Most information about a specimen is obtained by elastic scattering of electrons, but one cannot avoid inelastic scattering and therefore radiation damage by ionisation as a primary process of damage. This damage is a dose effect, being proportional to the product of lectron current density j and the irradiation time t in Coul.cm−2 as long as there is a negligible heating of the specimen.Therefore one has to determine the dose needed to produce secondary damage processes, which can be measured quantitatively by a chemical or physical effect in the thin specimen. The survival of micro-organisms or the decrease of photoconductivity and cathodoluminescence are such effects needing very small doses (see table).

‘Who Speaks?’ Morgenthaler and/or Lacan Behind the Couch

2020 ◽  
Vol 22 (1) ◽  
pp. 127-148
Author(s):  
Ulrike Körbitz
Keyword(s):  
Jacques Lacan ◽  
Developmental Psychology ◽  
Practical Work ◽  
Primary Process ◽  
Theoretical Perspectives

Is it possible to speak of conceptual conjunctions between Fritz Morgenthaler and Jacques Lacan? This question is explored in relation to the practical work of an analyst as she engages with their – at once completely different and yet complementary – theoretical perspectives. Both emphasize the active, demanding-desiring position of the analyst while simultaneously refusing any metapsychologically oriented interpretive technique. Both criticize the normative, denigrating impetus of too much psychoanalytic thinking, especially in the context of developmental psychology and pathologizing doctrine. They warn against too-certain knowledge on the analyst's part. Both emphasize primary-process drive-strivings and the emancipatory possibilities of psychoanalysis – as they both also attend particularly to the formal aspects of the analysand's speech.

Purines and Pyrimidines: Metabolism, Function and Potential as therapeutic options in neurodegenerative diseases

2020 ◽  
Vol 21 ◽  
Author(s):  
Debanjan Kundu ◽  
Vikash Kumar Dubey
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurodegenerative Disorders ◽  
Protein Misfolding ◽  
Molecular Mechanisms ◽  
Treatment Regimens ◽  
Loss Of Balance ◽  
Current Scenario ◽  
Unexplored Area ◽  
Molecular Origin ◽  
Purines And Pyrimidines

Abstract:: Various neurodegenerative disorders have molecular origin but some common molecular mechanisms. In the current scenario, there are very few treatment regimens present for advanced neurodegenerative diseases. In this context, there is an urgent need for alternate options in the form of natural compounds with an ameliorating effect on patients. There have been individual scattered experiments trying to identify potential values of various intracellular metabolites. Purines and Pyrimidines, which are vital molecules governing various aspects of cellular biochemical reactions, have been long sought as crucial candidates for the same, but there are still many questions that go unanswered. Some critical functions of these molecules associated with neuromodulation activities have been identified. They are also known to play a role in foetal neurodevelopment, but there is a lacuna in understanding their mechanisms. In this review, we have tried to assemble and identify the importance of purines and pyrimidines, connecting them with the prevalence of neurodegenerative diseases. The leading cause of this class of diseases is protein misfolding and the formation of amyloids. A direct correlation between loss of balance in cellular homeostasis and amyloidosis is yet an unexplored area. This review aims at bringing the current literature available under one umbrella serving as a foundation for further extensive research in this field of drug development in neurodegenerative diseases.

scholarly journals Molecular origin of viscoelasticity in mineralized collagen fibrils

2021 ◽  
Author(s):  
Mario Milazzo ◽  
Alessio David ◽  
Gang Seob Jung ◽  
Serena Danti ◽  
Markus J. Buehler
Keyword(s):  
Collagen Fibrils ◽  
Skeletal System ◽  
Mineralized Tissue ◽  
Molecular Origin ◽  
Mineralized Collagen

Bone is mineralized tissue constituting the skeletal system, supporting and protecting body organs and tissues. In addition to such fundamental mechanical functions, bone also plays a remarkable role in sound...

Perspectives on Astringency Sensation: An Alternative Hypothesis on the Molecular Origin of Astringency

2021 ◽  
Author(s):  
Francis Canon ◽  
Christine Belloir ◽  
Eric Bourillot ◽  
Hélène Brignot ◽  
Loïc Briand ◽  
...  
Keyword(s):  
Alternative Hypothesis ◽  
Molecular Origin
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