Characterization and rescue of a Drosophila model of prion disease; and The role of carcinine in signaling at the Drosophila photoreceptor synapse.

2008 ◽  
Author(s):  
Brendan Andrew. Gavin
Keyword(s):  
Prion Disease ◽  
Drosophila Model ◽  
Photoreceptor Synapse ◽  
Drosophila Photoreceptor

scholarly journals The Role of Carcinine in Signaling at the Drosophila Photoreceptor Synapse

PLoS Genetics ◽  
2007 ◽  
Vol 3 (12) ◽  
pp. e206 ◽  
Author(s):  
Brendan A Gavin ◽  
Susan E Arruda ◽  
Patrick J Dolph
Keyword(s):  
Photoreceptor Synapse ◽  
Drosophila Photoreceptor

scholarly journals The Role of Carcinine in Signaling at the Drosophila Photoreceptor Synapse

PLoS Genetics ◽  
2005 ◽  
Vol preprint (2007) ◽  
pp. e206
Author(s):  
Brendan Andrew Gavin ◽  
Susan E Arruda ◽  
Patrick J Dolph
Keyword(s):  
Photoreceptor Synapse ◽  
Drosophila Photoreceptor

Speciation and changes in male gene expression in Drosophila

Genome ◽  
2020 ◽  
pp. 1-11
Author(s):  
Bahar Patlar ◽  
Alberto Civetta
Keyword(s):  
Gene Expression ◽  
Reproductive Isolation ◽  
Potential Role ◽  
Regulation Of Gene Expression ◽  
Drosophila Model ◽  
Depth Analysis ◽  
The Impact ◽  
Plastic Responses ◽  
Male Gene

It has long been acknowledged that changes in the regulation of gene expression may account for major organismal differences. However, we still do not fully understand how changes in gene expression evolve and how do such changes influence organisms’ differences. We are even less aware of the impact such changes might have in restricting gene flow between species. Here, we focus on studies of gene expression and speciation in the Drosophila model. We review studies that have identified gene interactions in post-mating reproductive isolation and speciation, particularly those that modulate male gene expression. We also address studies that have experimentally manipulated changes in gene expression to test their effect in post-mating reproductive isolation. We highlight the need for a more in-depth analysis of the role of selection causing disrupted gene expression of such candidate genes in sterile/inviable hybrids. Moreover, we discuss the relevance to incorporate more routinely assays that simultaneously evaluate the potential effects of environmental factors and genetic background in modulating plastic responses in male genes and their potential role in speciation.

scholarly journals Role of Spastin in Apical Domain Control along the Rhabdomere Elongation in Drosophila Photoreceptor

PLoS ONE ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. e9480 ◽  
Author(s):  
Geng Chen ◽  
Garrett P. League ◽  
Sang-Chul Nam
Keyword(s):  
Apical Domain ◽  
Drosophila Photoreceptor

scholarly journals The Drosophila Model: Exploring Novel Therapeutic Compounds against Neurodegenerative Diseases

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 623 ◽  
Author(s):  
Sun Joo Cha ◽  
Hyeon-Ah Do ◽  
Hyun-Jun Choi ◽  
Mihye Lee ◽  
Kiyoung Kim
Keyword(s):  
Neurodegenerative Diseases ◽  
Fruits And Vegetables ◽  
Uv Light ◽  
Dietary Polyphenols ◽  
Drosophila Model ◽  
Therapeutic Compounds ◽  
Novel Drug ◽  
And Oxidative Stress ◽  
Drosophila Models

Polyphenols are secondary metabolites of plants, fruits, and vegetables. They act as antioxidants against free radicals from UV light, pathogens, parasites, and oxidative stress. In Drosophila models, feeding with various polyphenols results in increased antioxidant capacity and prolonged lifespan. Therefore, dietary polyphenols have several health advantages for preventing many human diseases, including cardiovascular diseases, cancer, and neurodegenerative diseases. However, the exact role of polyphenols in neurodegenerative diseases is still yet to be completely defined. This review focuses on the most recent studies related to the therapeutic effect of polyphenols in neurodegenerative disease management and provides an overview of novel drug discovery from various polyphenols using the Drosophila model.

The Neuroimmune Interface in Prion Diseases

Physiology ◽  
2000 ◽  
Vol 15 (5) ◽  
pp. 250-255
Author(s):  
Michael A. Klein ◽  
Adriano Aguzzi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immune System ◽  
Prion Disease ◽  
Neurodegenerative Disorders ◽  
Prion Diseases ◽  
The Central Nervous System

Prion diseases are fatal neurodegenerative disorders of animals and humans. Here we address the role of the immune system in the spread of prions from peripheral sites to the central nervous system and its potential relevance to iatrogenic prion disease.

Contribution of a Metal-Peroxide Adduct to Neurodegeneration Is Due to Its Oxidative Protease Activity

1999 ◽  
Vol 54 (12) ◽  
pp. 1107-1114 ◽  
Author(s):  
Yuzo Nishida ◽  
Satoshi Nishino
Keyword(s):  
Prion Disease ◽  
Protease Activity ◽  
Reaction Scheme ◽  
Theoretical Point ◽  
Metal Compounds ◽  
Age Related ◽  
The Moment ◽  
The Brain ◽  
Lateral Sclerosis

Many hypotheses have been developed to explain aging and age-related neurodegenerative disorders; one of the most compelling is the role of oxidative stress to induce changes in protease activity in brains of patients of Alzheimer’s disease and prion disease. At the moment however, there is no clear answer how protein degradation may be achieved in the brain. We have observed that several metal compounds can degrade proteins in the presence of hydrogen peroxide, and elucidated the reaction scheme based on the new theoretical point for the reactivity of a metal-peroxide adduct with η1-coordination mode. In this article we would like to point out the importance of a copper(II)-peroxide adduct to promote neurodegenerative diseases such as prion disease and amyotrophic lateral sclerosis through its oxidative protease function.

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