The First Description of Docetaxel-Induced Recall Inflammatory Skin Reaction after Previous Drug Extravasation

2011 ◽  
Vol 45 (2) ◽  
pp. 277-277 ◽  
Author(s):  
Frauke Kramer ◽  
Cordula Schippert ◽  
Franziska Rinnau ◽  
Peter Hillemanns ◽  
Tjoung-Won Park-Simon
Keyword(s):  
Skin Reaction ◽  
Drug Extravasation ◽  
Inflammatory Skin

Recall inflammatory skin reaction after use of pegylated liposomal doxorubicin in site of previous drug extravasation

2006 ◽  
Vol 7 (2) ◽  
pp. 186-187 ◽  
Author(s):  
Andrea Saini ◽  
Alfredo Berruti ◽  
Paola Sperone ◽  
Raffaella Bitossi ◽  
Marco Tampellini ◽  
...  
Keyword(s):  
Skin Reaction ◽  
Liposomal Doxorubicin ◽  
Pegylated Liposomal Doxorubicin ◽  
Drug Extravasation ◽  
Inflammatory Skin

scholarly journals THE IMMUNOLOGICAL SPECIFICITY OF STAPHYLOCOCCI

1935 ◽  
Vol 62 (1) ◽  
pp. 31-37 ◽  
Author(s):  
L. A. Julianelle ◽  
C. W. Wieghard
Keyword(s):  
Skin Reaction ◽  
Skin Reactions ◽  
Specific Antibodies ◽  
Immunological Specificity ◽  
Inflammatory Skin ◽  
Species Specific

1. The carbohydrates derived from Staphylococcus are type specific. 2. The specific carbohydrates fail to induce formation of antibodies in rabbits. 3. Acetylation or adsorption of the carbohydrates on collodion particles does not render them antigenic. 4. The specific carbohydrates may be employed to elicit immediate, type specific, skin reactions in patients with Staphylococcus infection. 5. The protein of Staphylococcus is species specific. 6. The protein is antigenic and stimulates in rabbits species specific antibodies. 7. The protein causes in hypersensitive individuals a species specific, delayed, inflammatory skin reaction.

scholarly journals Effect ofDangguibohyul-Tang, a Mixed Extract ofAstragalus membranaceusandAngelica sinensis, on Allergic and Inflammatory Skin Reaction Compared with Single Extracts ofAstragalus membranaceusorAngelica sinensis

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
You Yeon Choi ◽  
Mi Hye Kim ◽  
Jongki Hong ◽  
Kyuseok Kim ◽  
Woong Mo Yang
Keyword(s):  
Atopic Dermatitis ◽  
Skin Reaction ◽  
Inflammatory Mediators ◽  
Skin Diseases ◽  
Clinical Symptoms ◽  
Treated Group ◽  
Total Serum ◽  
Angelica Sinensis ◽  
Skin Thickness ◽  
Inflammatory Skin

Dangguibohyul-tang(DBT), herbal formula composed ofAstragalus membranaceus(AM) andAngelica sinensis(AS) at a ratio of 5 : 1, has been used for the treatment of various skin diseases in traditional medicine. We investigated the effect of DBT on allergic and inflammatory skin reaction in atopic dermatitis-like model compared to the single extract of AM or AS. DBT treatment showed the remission of clinical symptoms, including decreased skin thickness and scratching behavior, the total serum IgE level, and the number of mast cells compared to DNCB group as well as the single extract of AM- or AS-treated group. Levels of cytokines (IL-4, IL-6, IFN-γ, TNF-α, and IL-1β) and inflammatory mediators (NF-κB, phospho-IκBα, and phospho-MAPKs) were significantly decreased in AM, AS, and DBT groups. These results demonstrated that AM, AS, and DBT may have the therapeutic property on atopic dermatitis by inhibition of allergic and inflammatory mediators and DBT formula; a mixed extract of AM and AS based on the herb pairs theory especially might be more effective on antiallergic reaction as compared with the single extract of AM or AS.

scholarly journals Efficacy of topical agents in the background therapy of atopic dermatitis in children

2018 ◽  
pp. 122-127 ◽  
Author(s):  
E. I. Danilova ◽  
O. Yu. Trusova ◽  
V. V. Sumenko
Keyword(s):  
Atopic Dermatitis ◽  
Skin Reaction ◽  
Skin Disease ◽  
Topical Agent ◽  
Efficacy And Safety ◽  
High Efficacy ◽  
Inflammatory Skin Disease ◽  
Background Therapy ◽  
The Mean ◽  
Inflammatory Skin

Atopic dermatitis (AtD) is a chronic inflammatory skin disease with complex etiopathogenesis, which begins in childhood. Purpose of the study: To evaluate the clinical efficacy and safety of Skin-cap cream as a topical background therapy in children with diabetes. Materials and methods: The study included 77 children aged 1 to 11 years with moderately severe AtD with a widespread lesion of the skin (33,5%), skin itching, inflammatory skin reaction and exacerbations occurring 3 to 4 times a year. During the study, two arms of children were formed: the treatment arm - 39 children with an average course of the disease (SCORAD index = 33,9 ± 2,2 points), who received the background therapy with the prescription of Skin-cap cream. Comparison arm: 38 children (SCORAD index = 34,2 ± 2,1 points), who received Afloderm cream as a background therapy. Results: Patients of the treatment arm showed a significant dynamics of relief of AtD symptoms as compared with the comparison arm. the differences in the duration of dermal manifestations were as follows: in the treatment arm, the time of reducing hyperaemia was 4,4 ± 1,2 days, in the comparison arm, hyperaemia was reduced at 5,7 ± 1,5 days (p< 0.05), the mean duration of alleviation of the skin itching was 3,0 ± 0,9 days and 5,8 ± 1,4 days (p< 0,05) at 6,8 and 7,3 days in the treatment arm and the comparison arm, respectively. Conclusions: The conducted study confirmed the high efficacy of the use of Skin-cap cream as a topical agent for background therapy of AtD, as compared to topical glucocorticosteroids.

Radiation Recall Dermatitis after Bortezomib Therapy.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 5103-5103
Author(s):  
Alpesh J. Amin ◽  
Michael Maroules
Keyword(s):  
Multiple Myeloma ◽  
Radiation Therapy ◽  
Skin Reaction ◽  
Causative Agent ◽  
Drug Hypersensitivity ◽  
Similar Reaction ◽  
Radiation Recall ◽  
Inflammatory Skin ◽  
Radiation Recall Dermatitis ◽  
Recall Dermatitis

Abstract Introduction: Radiation recall dermatitis (RRD) is an inflammatory skin reaction at a site of previous radiation therapy after the administration of a medication, usually a chemotherapeutic agent. A radiation recall reaction has not been previously reported with bortezomib. Case Report: A seventy-year-old man with stage III IgD multiple myeloma was treated with bortezomib after previous treatments with pulse decadron and cyclophosphamide. The patient was treated ten years earlier for a chest wall sarcoma with a local resection and radiation therapy to the tumor bed. After receiving bortezomib therapy for multiple myeloma, the patient developed erythema, desquamation, and ulceration only at the site of radiation therapy ten years prior. The patient received a dose reduced second infusion, causing a similar reaction. Discussion: RRD is an inflammatory skin reaction that develops in a previously irradiated area after administration of certain promoting agents, most often with chemotherapy. Unlike radiation enhancement, there may be a long interval between the eruption and the administration of the causative agent. A number of drugs have been associated with this phenomenon, particularly the anthracyclines. Bortezomib has not been previously described as a causative agent for RRD. Erythema is the most common sign, which may be painful. Vesiculation, desquamation, and ulceration have also been reported. Histologically, the involved areas reveal epidermal dysplasia, necrotic keratinocytes, mixed inflammatory reaction, and sometimes psoriasiform dermatitis. Dose reduction, and the use of corticosteroids have been used to prevent recurrence of RRD, although rechallenge with the same agent may not lead to RRD again. The pathogenesis of this local phenomenon is not well understood, although an idiosyncratic drug hypersensitivity reaction has been proposed.

Changes in CD44 isoform expression during inflammatory skin disease

1997 ◽  
Vol 22 (03) ◽  
pp. 128-133
Author(s):  
A.J. HARRIS ◽  
D. DEAN ◽  
S. BURGE ◽  
F. WOJNAROWSKA
Keyword(s):  
Skin Disease ◽  
Inflammatory Skin Disease ◽  
Inflammatory Skin ◽  
Isoform Expression

Asians on Phenytoin at High Skin Reaction Risk

2009 ◽  
Vol 39 (2) ◽  
pp. 17
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Skin Reaction
Sign in / Sign up

Export Citation Format

Share Document