scholarly journals What Types of Inappropriate Prescribing Predict Adverse Drug Reactions in Older Adults?

2010 ◽  
Vol 44 (6) ◽  
pp. 1110-1111 ◽  
Author(s):  
Joseph T Hanlon ◽  
Kenneth E Schmader
Keyword(s):  
Older Adults ◽  
Adverse Drug Reactions ◽  
Inappropriate Prescribing ◽  
Drug Reactions

scholarly journals Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review

2016 ◽  
Vol 24 (0) ◽  
Author(s):  
Maria Cristina Soares Rodrigues ◽  
Cesar de Oliveira
Keyword(s):  
Older Adults ◽  
Drug Interactions ◽  
Adverse Drug Reactions ◽  
Inappropriate Prescribing ◽  
Integrative Review ◽  
Geriatric Nursing ◽  
Drug Reactions ◽  
Exclusion Criteria ◽  
Drug Classes ◽  
Negative Health Outcomes

ABSTRACT Objective: to identify and summarize studies examining both drug-drug interactions (DDI) and adverse drug reactions (ADR) in older adults polymedicated. Methods: an integrative review of studies published from January 2008 to December 2013, according to inclusion and exclusion criteria, in MEDLINE and EMBASE electronic databases were performed. Results: forty-seven full-text studies including 14,624,492 older adults (≥ 60 years) were analyzed: 24 (51.1%) concerning ADR, 14 (29.8%) DDI, and 9 studies (19.1%) investigating both DDI and ADR. We found a variety of methodological designs. The reviewed studies reinforced that polypharmacy is a multifactorial process, and predictors and inappropriate prescribing are associated with negative health outcomes, as increasing the frequency and types of ADRs and DDIs involving different drug classes, moreover, some studies show the most successful interventions to optimize prescribing. Conclusions: DDI and ADR among older adults continue to be a significant issue in the worldwide. The findings from the studies included in this integrative review, added to the previous reviews, can contribute to the improvement of advanced practices in geriatric nursing, to promote the safety of older patients in polypharmacy. However, more research is needed to elucidate gaps.

scholarly journals 24In-Hospital Adverse Drug Reactions in Hospitalised Older Adults - A Systematic Review

2018 ◽  
Vol 47 (suppl_5) ◽  
pp. v13-v60 ◽  
Author(s):  
Emma Jennings ◽  
Kevin Murphy ◽  
Paul Gallagher ◽  
Denis O’Mahony
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Adverse Drug Reactions ◽  
Drug Reactions

scholarly journals Common Causes and Characteristics of Adverse Drug Reactions in Older Adults: A Retrospective Study

2020 ◽  
Author(s):  
Seong-Dae Woo ◽  
Jiwon Yoon ◽  
Go-Eun Doo ◽  
Youjin Park ◽  
Youngsoo Lee ◽  
...  
Keyword(s):  
Older Adults ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Younger Patients ◽  
Iodinated Contrast ◽  
Common Causes ◽  
Aging Populations ◽  
Pharmacovigilance Center ◽  
Inflammatory Drugs ◽  
Rate Ratios

Abstract Background: Aging populations are often accompanied by comorbidity and polypharmacy, leading to increases in adverse drug reactions (ADRs). We sought to evaluate the causes and characteristics of ADRs in older Korean adults (≥65 years) in comparison to younger individuals (<65 years). Methods: Of 37,523 cases reported at a Korean pharmacovigilance center from 2011 to 2018, we reviewed 18,842 ADRs of certain or probable causality on the basis of WHO-UMC criteria. We estimated the number of ADRs per 1,000 patients exposed to the major culprit drugs, and incidence rate ratios were obtained to assess high- and low-risk medications in older adults. Results: In total, 4,152 (22.0%) ADRs were reported for 3,437 older adults (mean age, 74.6 years and 57.3% female). Tramadol (rate ratio, 1.32; 95% confidence interval [CI], 1.21-1.44; P <0.001) and fentanyl (1.49, 1.16-1.92, P =0.002) posed higher risks of ADRs in the older adults, whereas nonsteroidal anti-inflammatory drugs (NSAIDs) (0.35, 0.30-0.40, P <0.001) and iodinated contrast media (ICM) (0.82, 0.76-0.89, P <0.001) posed lower risks. Ratios of serious ADRs to NSAIDs (odds ratio, 2.16; 95% CI, 1.48-3.15; P <0.001) and ICM (2.09, 1.36-3.21, P= 0.001) were higher in the older adults than in the younger patients. Analgesics primarily elicited cutaneous ADRs in the younger patients and gastrointestinal reactions in the older adults. ICM more commonly led to anaphylaxis in the older adults than the younger patients (3.0% vs. 1.6%, P =0.019). Conclusion: For early detection of ADRs in older adults, better understanding of differences in the causes and characteristics thereof in comparison to the general population is needed.

Older Adults' Response to Analgesic Adverse Drug Reactions: A Pilot Study

2018 ◽  
Vol 19 (4) ◽  
pp. 333-339 ◽  
Author(s):  
Deborah Dillon McDonald ◽  
Sarah Coughlin ◽  
Candy Jin
Keyword(s):  
Older Adults ◽  
Pilot Study ◽  
Adverse Drug Reactions ◽  
Drug Reactions

scholarly journals Study of adverse drug reactions and clinical profile of elderly in relation to polypharmacy

2019 ◽  
Vol 10 (6) ◽  
pp. 80-84
Author(s):  
Nagaraja BS ◽  
Keerthana Sharma
Keyword(s):  
Older Adults ◽  
Adverse Drug Reactions ◽  
The Elderly ◽  
Control Group ◽  
Case Group ◽  
Drug Reactions ◽  
Age Related ◽  
Improve Compliance ◽  
Clinical Conditions

Background: Polypharmacy is a becoming more prevalent in older adults and adverse risk increases with age-related change. Adverse drug reactions (ADRs) are common in older adults and worrisome aspect of treatment in elderly. Aims and Objective: The study aimed to identify the common clinical conditions leading to polypharmacy and to compare the adverse drug profiles of the 2 groups. Materials and Methods: This case-control study was conducted in Hospitals attached to BMCRI, where 200 patients aged 65 or more were interviewed. 100 elderly patients using 5 or more drugs were identified as cases and assessed against a control group of 100 patients. Results: Our study found that ADRs were found to be three times higher in individuals on polypharmacy compared to the control group (OR 3.4675 95% CI 1.6241 to 7.4035). The most commonly occurring ADRs were dyspepsia (OR 1.9259), drowsiness (OR 3.5926) and fatigue (OR 1.5319) with increased incidence in the case group. The most common conditions associated with polypharmacy were found to be hypertension (53%), diabetes mellitus(46%), COPD(14%) and IHD(14%). 66% of the study group had two or more of the above diseases, whereas in the control group only 32% had multiple illnesses. The most commonly prescribed medications were antihypertensives (61%), hypolipidemics (44%), antiplatelets (41%) and antibiotics(40%). Conclusion: Polypharmacy in the elderly comes with a significant increase in adverse effects. The reduced pill burden will not only decrease ADRs and improve compliance, but will also result in greater patient satisfaction and mental health, thereby improving the quality of geriatric care.

scholarly journals Potentially inappropriate prescribing and adverse drug reactions in the elderly: a population-based study

2015 ◽  
Vol 71 (12) ◽  
pp. 1525-1533 ◽  
Author(s):  
Khedidja Hedna ◽  
Katja M. Hakkarainen ◽  
Hanna Gyllensten ◽  
Anna K. Jönsson ◽  
Max Petzold ◽  
...  
Keyword(s):  
Adverse Drug Reactions ◽  
Inappropriate Prescribing ◽  
The Elderly ◽  
Population Based ◽  
Potentially Inappropriate Prescribing ◽  
Drug Reactions ◽  
Population Based Study

Adverse Drug Reactions in Older Adults: a Retrospective Study from Pharmacovigilance

Therapies ◽  
2012 ◽  
Vol 67 (5) ◽  
pp. 471-476 ◽  
Author(s):  
Rim Charfi ◽  
Sihem El Aïdli ◽  
Ahmed Zaïem ◽  
Sarah Kastalli ◽  
Samia Sraïri ◽  
...  
Keyword(s):  
Older Adults ◽  
Retrospective Study ◽  
Adverse Drug Reactions ◽  
Drug Reactions
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