Early Experiences and Clinical Implications of Drug-Eluting Stents: Part 1

2004 ◽  
Vol 38 (4) ◽  
pp. 661-669 ◽  
Author(s):  
Pang H Chong ◽  
Judy WM Cheng
Keyword(s):  
Drug Eluting Stents ◽  
Clinical Implications ◽  
Early Experiences ◽  
Drug Eluting

scholarly journals Continuation of dual anti-platelet therapy after drug-eluting stents in primary angioplasty beyond 12 months

F1000Research ◽  
2012 ◽  
Vol 1 ◽  
pp. 53
Author(s):  
Iman Mohasseb ◽  
Christian A Gericke
Keyword(s):  
Meta Analysis ◽  
Bare Metal Stents ◽  
Primary Angioplasty ◽  
Drug Eluting Stents ◽  
Metal Stents ◽  
Clinical Implications ◽  
Bare Metal ◽  
Original Publication ◽  
Anti Platelet Therapy ◽  
Drug Eluting

In this correspondence we discuss the results of the meta-analysis by De Luca et al. (2012) in the Archives of Internal Medicine which found that late myocardial reinfarction and stent thrombosis is more common in drug-eluting stents than in bare-metal stents. We discuss the clinical implications of this paper for dual anti-platelet therapy which did not receive sufficient attention in the original publication and the accompanying editorial.

Very Late Stent Thrombosis in Drug-Eluting Stents New Observations and Clinical Implications

2019 ◽  
Vol 27 (6) ◽  
pp. 279-285
Author(s):  
Xiang Wang ◽  
Xinxin Chen ◽  
Wanqing Sun ◽  
Tao Tian ◽  
Shanshan Zhou ◽  
...  
Keyword(s):  
Stent Thrombosis ◽  
Drug Eluting Stents ◽  
Clinical Implications ◽  
Late Stent Thrombosis ◽  
Very Late Stent Thrombosis ◽  
Drug Eluting

scholarly journals Coronary Stent Strut Fractures: Classification, Prevalence and Clinical Associations

2021 ◽  
Vol 10 (8) ◽  
pp. 1765
Author(s):  
Katharina Schochlow ◽  
Melissa Weissner ◽  
Florian Blachutzik ◽  
Niklas F. Boeder ◽  
Monique Tröbs ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Multivariable Analysis ◽  
Drug Eluting Stents ◽  
Clinical Implications ◽  
Device Failure ◽  
Stent Strut ◽  
Drug Eluting ◽  
Bifurcation Lesions ◽  
Clinical Associations ◽  
Device Complications

Introduction. The frequency, characteristics and clinical implications of Strut fractures (SFs) remain incompletely understood. Methods and results. A total of 185 (160 patients) newer-generation drug-eluting stents (DES) were imaged. SFs were found in 21 DES (11.4%) and were classified in four patterns: one single stacked strut (41%); two or more stacked struts (23%); deformation without gap (27%); transection (9%). In multivariable analysis, calcific and bifurcation lesions were associated with SF in DES (OR: 3.5 [1.1–11] and 4.0 [2.2–7.2], p < 0.05). Device eccentricity and asymmetry as well as optical coherence tomography (OCT) features of impaired strut healing were also associated with SF. The prevalence of fractures was similar in a set of 289 bioresorbable scaffolds (BRS). In a separate series of 20 device thromboses and 36 device restenoses, the prevalence of SF was higher (61.2% of DES and 66.7% of BRS, p < 0.001 for both), with a higher frequency of complex SF patterns (p < 0.0001). In logistic regression analysis, fractures were a correlate of device complications (p < 0.0001, OR = 24.9 [5.6–111] for DES and OR = 6.0 [1.8–20] for BRS). Discussion. The prevalence of OCT-diagnosed SF was unexpectedly high in the setting of elective controls and it increased by about three-fold in the setting of device failure. Fractures were associated with increased lesion complexity and device asymmetry/eccentricity and were more frequent in the setting of device failure such as restenosis and thrombosis.

Drug-Eluting Stents Equal on Thrombosis

2012 ◽  
Vol 45 (14) ◽  
pp. 8
Author(s):  
MICHELE G. SULLIVAN
Keyword(s):  
Drug Eluting Stents ◽  
Drug Eluting

Drug-eluting stents for treatment of focal infrapopliteal lesions

VASA ◽  
2012 ◽  
Vol 41 (2) ◽  
pp. 90-95 ◽  
Author(s):  
Rastan ◽  
Noory ◽  
Zeller
Keyword(s):  
Limb Salvage ◽  
Bare Metal Stents ◽  
Target Lesion ◽  
Drug Eluting Stents ◽  
Metal Stents ◽  
Target Lesion Revascularisation ◽  
Randomized Studies ◽  
Drug Eluting ◽  
The Mean

We have investigated the role of drug-eluting stents on patency rates after treatment of focal infrapopliteal lesions in patients with intermittent claudication and critical limb ischemia. Reports indicate that drug-eluting stents reduce the risk of restenosis after percutaneous infrapopliteal artery revascularization. A Pub Med, EMBASE, Cochrane database review search of non-randomized studies investigating patency rates, target lesion revascularisation rates, limb salvage rates and mortality rates in an up to 3-year follow-up period after drug-eluting stent placement was conducted. In addition, preliminary results of randomized studies comparing drug-eluting stents with bare-metal stents and plain balloon angioplasty in treatment of focal infrapopliteal lesions were included in this review. A total of 1039 patients from 10 non-randomized and randomized studies were included. Most commonly used drug-eluting stents were sirolimus-eluting. The mean follow-up period was 12.6 (range 8 - 24). The mean 1-year primary patency rate was 86 ± 5 %. The mean target lesion revascularization rate and limb salvage rate was 9.9 ± 5 % and 96.6 %±4 %, respectively. Results from non-randomized and preliminary results from prospective, randomized trials show a significant advantage for drug-eluting stents in comparison to plain balloon angioplasty and bare-metal stents concerning target lesion patency and in parts target lesion revascularisation. No trial reveals an advantage for drug-eluting stents with regard to limb salvage and mortality.

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