Rhabdomyolysis and Acute Renal Failure following an Ethanol and Diphenhydramine Overdose

2003 ◽  
Vol 37 (4) ◽  
pp. 538-542 ◽  
Author(s):  
Curtis E Haas ◽  
Yanina Magram ◽  
Archana Mishra
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Early Recognition ◽  
Drug Induced ◽  
Case Summary ◽  
Common Causes ◽  
Diphenhydramine Overdose ◽  
Life Threatening ◽  
High Index Of Suspicion ◽  
Oliguric Acute Renal Failure

OBJECTIVE: To report a case of nontraumatic rhabdomyolysis complicated by oliguric, acute renal failure following an intentional overdose of ethanol and diphenhydramine. CASE SUMMARY: A 21-year-old white man was admitted through the emergency department following an intentional overdose of ethanol and diphenhydramine. The patient subsequently developed acute renal failure, and a diagnosis of nontraumatic rhabdomyolysis was made. With the absence of other common causes in this case, the rhabdomyolysis was believed to be due to the combined ethanol and diphenhydramine overdose. DISCUSSION: Rhabdomyolysis is a severe and life-threatening syndrome caused by various insults to skeletal muscle, including drug-induced injury. Early detection and institution of effective treatments are essential to minimizing the complications of this syndrome. A delay in establishing the diagnosis in this case likely contributed to the severity of the renal failure. CONCLUSIONS: Nontraumatic rhabdomyolysis is an uncommon adverse outcome of drug and toxin ingestion. Due to the potential severity of the complications of this syndrome and the importance of early recognition and treatment to prevent renal failure, clinicians should have a high index of suspicion for rhabdomyolysis following overdoses that involve alcohol or antihistamines.

Alcohol Related Non-traumatic Rhabdomyolysis and Compartment Syndrome

2007 ◽  
Vol 6 (1) ◽  
pp. 33-34
Author(s):  
JPL Ong ◽  
◽  
LA Thomas ◽  
Keyword(s):  
Skeletal Muscle ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Lower Extremity ◽  
Compartment Syndrome ◽  
Early Recognition ◽  
Clinical Entity ◽  
Threatening Condition ◽  
Life Threatening ◽  
Renal Support

Rhabdomyolysis is a serious and life-threatening condition in which skeletal muscle is damaged, commonly resulting in acute renal failure. The causes of this clinical entity can be traumatic and non-traumatic. In the latter group, alcohol is the commonest cause. This report describes the case of a 25 year old man who presented with rhabdomyolysis leading to acute renal failure after an alcohol binge. He presented with painful legs and lower extremity compartment syndrome. The patient recovered with surgical fasciotomy and renal support. This case illustrates the importance of early recognition and treatment of alcohol related non-traumatic rhabdomyolysis and compartment syndrome.

scholarly journals A Rare Adverse Event of Rhabdomyolysis Caused by Sacubitril/Valsartan

Diseases ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 38 ◽  
Author(s):  
Prashanth Rawla ◽  
Jeffrey Pradeep Raj ◽  
Sajid Melvin George ◽  
Pavani Nathala ◽  
Anantha R. Vellipuram
Keyword(s):  
Renal Failure ◽  
Adverse Event ◽  
Acute Renal Failure ◽  
Muscle Damage ◽  
Cardiac Arrhythmias ◽  
Skeletal Muscles ◽  
Creatine Phosphokinase ◽  
Drug Induced ◽  
Life Threatening ◽  
Extensive Damage

Rhabdomyolysis is caused by extensive damage to skeletal muscles resulting in elevated creatine phosphokinase (CPK), Lactate dehydrogenase (LDH), and aspartate aminotransferase (AST), leading to life-threatening consequences like acute renal failure, cardiac arrhythmias, and hyperthermia. A variety of causes for muscle damage are known, and one of the most common is drug-induced. Statins and many other agents are known to induce muscle damage, but here we report Entresto™ (Sacubitril/Valsartan) induced rhabdomyolysis which has not been previously reported as solely responsible in the literature.

Life-threatening hypercalcemia in patients with rhabdomyolysis-induced oliguric acute renal failure

2010 ◽  
Vol 24 (1) ◽  
pp. 128-131 ◽  
Author(s):  
Giorgio Graziani ◽  
Albania Calvetta ◽  
David Cucchiari ◽  
Serenella Valaperta ◽  
Alessandro Montanelli
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Life Threatening ◽  
Oliguric Acute Renal Failure

scholarly journals Seven-Digit Creatine Kinase in Acute Rhabdomyolysis in a Child

2017 ◽  
Vol 4 ◽  
pp. 2329048X1668439 ◽  
Author(s):  
Nuha Basheer ◽  
Sirin Mneimneh ◽  
Mariam Rajab
Keyword(s):  
Renal Failure ◽  
Creatine Kinase ◽  
Acute Renal Failure ◽  
Creatine Kinase Level ◽  
Peak Plasma ◽  
Renal Dialysis ◽  
Acute Rhabdomyolysis ◽  
Threatening Condition ◽  
Life Threatening ◽  
Plasma Creatine Kinase

Rhabdomyolysis is an acute life-threatening condition that can occur in childhood secondary to many causes. The authors report the case of a 3-year-old male child who presented with acute rhabdomyolysis. The peak plasma creatine kinase level was extremely high. The 2 main causes of rhabdomyolysis in childhood are viral myositis and trauma, which can sometimes lead to acute renal failure. The highest creatine kinase levels reported in the literature so far was a 6-digit level in 2014 case report. In this study, the authors report the case of a 7-digit creatine kinase level in a child secondary to viral myositis who did not require renal dialysis.

scholarly journals Acute Renal Failure in a Tertiary Care Center in Nepal

2005 ◽  
Vol 44 (158) ◽  
Author(s):  
Sudha Khakurel ◽  
P R Satyal ◽  
R K Agrawal ◽  
P K Chhetri ◽  
R Hada
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Bacillary Dysentery ◽  
Care Center ◽  
Tertiary Care ◽  
Acute Interstitial Nephritis ◽  
Female Age ◽  
Tubular Necrosis ◽  
Common Causes ◽  
Urate Nephropathy

From July 1998 to July 1999, 45 cases of acute renal failure were treated at Bir Hospital, Kathmandu. Outof which 24 were male and 21 were female. Age ranged from 11 months to 84 years with mean age being 35years and 9 cases were below 10 years.Four cases with pre-renal azotaemia and twenty five cases of acute tubular necrosis (ATN) accounted for64% of all cases. These were due to gastroenteritis 10, sepsis 6, post surgical 1, trauma 1 and obstreticalcomplications 5. Multiple hornet stings were responsible for acute renal failure in 3 cases, acute urate nephropathy in 1 case and miscellaneous causes in 2 cases.Glomerulonephritis / vasculitis accounted for 17.7%, acute interstitial nephritis 4.4%, haemotytic uraemicsyndrome (HUS) 6.6%, and post renal azotaemia in 6.6% of all cases. Mean serum creatinine was 8 mg/dl,mean blood urea 190 mg/dl. Eight cases were treated only conservatively, eighteen received haemodialysis,fourteen received peritoneal dialysis, three received both and two refused for dialysis. Average duration ofhospital stay was 13.6 days. Out of the forty-five cases twenty-nine recovered normal renal function, tenexpired, two recovered partially, two progressed to chronic renal failure and two left against medical advice.Overall mortality was 22.2%.Common causes of acute renal failure in our setting were gastroenteritis (22%) and sepsis (20%). HUS wasexclusively seen in children following bacillary dysentery. Multiple hornet stings is an important cause ofacute renal failure in our country.

Ketorolac-induced Acute Renal Failure in a Previously Healthy Adolescent

PEDIATRICS ◽  
1996 ◽  
Vol 98 (2) ◽  
pp. 294-296
Author(s):  
Marcia L. Buck ◽  
Victoria F. Norwood
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Outpatient Setting ◽  
Hospitalized Patients ◽  
Major Surgery ◽  
Healthy Adolescent ◽  
Neurologic Function ◽  
Traditional Therapies ◽  
Oliguric Acute Renal Failure ◽  
Dose Form

Ketorolac has become an important component of analgesic regimens for children as well as adults because of its lack of adverse effects on respiratory, cardiovascular, and neurologic function. Although initially used parenterally in hospitalized patients, the development of an oral ketorolac dose form extended its use to the outpatient setting, where its potency has been considered an advantage over traditional therapies.1-3 Several cases of hyperkalemia and oliguric acute renal failure associated with ketorolac use have been reported in the medical literature.4-12 Elderly hospitalized patients receiving large doses of ketorolac intramuscularly (IM) after major surgery seem to be at greatest risk.

Acute Tubular Necrosis: Diagnosis, Treatment, and Nursing Implications

1992 ◽  
Vol 3 (3) ◽  
pp. 688-697
Author(s):  
Sara Douglas
Keyword(s):  
At Risk ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Critical Care ◽  
Acute Tubular Necrosis ◽  
Early Recognition ◽  
Recovery Phase ◽  
Vital Role ◽  
Laboratory Findings ◽  
Tubular Necrosis

Acute tubular necrosis (ATN) is the most common cause of acute renal failure. Early recognition of patients who are at risk for ATN can prevent or improve the course of ATN. Acute renal failure is classified as prerenal, intrinsic, or postrenal disease. ATN is classified as a type of intrinsic renal disease. The clinical course of ATN is divided into the renal failure phase, diuretic phase, and recovery phase, with each phase having distinct symptoms and laboratory findings. Diagnosis of ATN often is complicated and confusing; understanding of laboratory findings can facilitate the critical care nurse’s ability to assess those at risk for ATN. The care and treatment of the patient with ATN is complicated, and specific treatments are discussed in detail. The critical care nurse can play a vital role in identifying the patient at risk, preventing the development of ATN in those at risk, and providing appropriate care for those who develop ATN

scholarly journals PUK3 DRUG-INDUCED ACUTE RENAL FAILURE USING THE FDA ADVERSE EVENT REPORTING SYSTEM DATABASE

2011 ◽  
Vol 14 (3) ◽  
pp. A74
Author(s):  
A.M. Alhammad ◽  
M.A. Al Hawaj ◽  
A.J. Alsalman ◽  
Y.N. Alhashem ◽  
S.E. Harpe ◽  
...  
Keyword(s):  
Renal Failure ◽  
Adverse Event ◽  
Acute Renal Failure ◽  
Reporting System ◽  
Adverse Event Reporting System ◽  
Adverse Event Reporting ◽  
Drug Induced ◽  
Event Reporting ◽  
System Database

scholarly journals Aggravation of non-steroidal anti-inflammatory drug-induced hepatitis and acute renal failure by slimming drug containing anthraquinones

2004 ◽  
Vol 19 (7) ◽  
pp. 1916-1917 ◽  
Author(s):  
F. K. Li ◽  
C.-K. Lai ◽  
W. T. Poon ◽  
A. Y. W. Chan ◽  
K. W. Chan ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Drug Induced ◽  
Inflammatory Drug ◽  
Anti Inflammatory
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