Neurotoxic Syndrome Associated with Risperidone and Fluvoxamine

2002 ◽  
Vol 36 (3) ◽  
pp. 440-443 ◽  
Author(s):  
Roy R Reeves ◽  
James E Mack ◽  
John J Beddingfield
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Serotonin Syndrome ◽  
Adverse Reactions ◽  
African American Woman ◽  
American Woman ◽  
Signs And Symptoms ◽  
Concomitant Treatment ◽  
Low Doses

OBJECTIVE: To report a case of a neurotoxic syndrome in a patient undergoing concomitant treatment with risperidone and fluvoxamine. CASE REPORT: A 24-year-old African American woman hospitalized for psychosis was unresponsive to risperidone. Because of obsessive symptoms, low doses of fluvoxamine were added to her treatment regimen. Within 2 days, she developed confusion, diaphoresis, diarrhea, hyperreflexia, and myoclonus, which then progressed to rigidity, fever, and unresponsiveness, requiring endotracheal intubation. Symptoms resolved over 10 days with discontinuation of medication, hydration, and bromocriptine 5 mg 3 × daily. Ultimately, she was treated with olanzapine and fluvoxamine without adverse effects. DISCUSSION: This represents the first reported case of a neurotoxic syndrome secondary to treatment with risperidone and fluvoxamine. Differential diagnosis between neuroleptic malignant syndrome (NMS) and serotonin syndrome (SS) could not be accurately determined because of the overlap of signs and symptoms of both syndromes. NMS and SS may represent different aspects of a more generalized neurotoxic syndrome. This could be an important consideration in formulating treatment for neurotoxic syndromes. CONCLUSIONS: Clinicians should be aware of potentially serious adverse reactions that may occur during concomitant treatment with antipsychotics and selective serotonin-reuptake inhibitors.

scholarly journals Risperidone-Induced Neutropenia in a Schizophrenic Patient: A Case Report and Literature Review

2021 ◽  
Vol 2021 ◽  
pp. 1-3 ◽  
Author(s):  
Ayodele Atolagbe ◽  
Stanley Nkemjika ◽  
Olusegun Popoola ◽  
Oluwatoyin Oladeji ◽  
Irina Kogan ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Case Report ◽  
Adverse Reactions ◽  
African American Woman ◽  
American Woman ◽  
Severe Neutropenia ◽  
Blood Dyscrasia ◽  
Normal Limits ◽  
Second Generation Antipsychotic ◽  
Risperidone Treatment

Neutropenia is an adverse effect of various pharmacological therapies, including antipsychotics. Among the second-generation antipsychotic (SGA) medications, clozapine is most notable for neutropenic adverse effect. Risperidone, another SGA drug, is linked mainly with metabolic adverse effects, but rarely, blood dyscrasia adverse reactions have been reported. Hence, we report the case of a 56-year-old African American woman who developed severe neutropenia following two weeks of oral risperidone treatment. Her neutrophil levels returned to normal limits following discontinuation of risperidone and switching to haloperidol.

scholarly journals Solitary Skeletal Muscle Metastasis as First Site of Recurrence of Cervical Cancer: A Case Report

2017 ◽  
Vol 10 (2) ◽  
pp. 694-698 ◽  
Author(s):  
Indumathy Varadarajan ◽  
Aparna Basu ◽  
Sherri Besmer ◽  
Jaganmohan Poli ◽  
Scott Richard ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cervical Cancer ◽  
Case Report ◽  
African American Woman ◽  
American Woman ◽  
Extensive Literature ◽  
Upper Arm ◽  
Skeletal Muscle Metastasis ◽  
Muscle Metastasis

Cervical cancer is the fourth most common cancer in women worldwide, with a large majority of prevalence (85%) in developing countries. As of 2012, it accounts for 7.5% of all female cancer deaths. Despite its high prevalence, skeletal muscle metastasis from cervical cancer is extremely uncommon. In our extensive literature search, we were able to find only 8 cases where skeletal muscle metastasis was the only site of recurrence. We report a case of a 52-year-old African-American woman with a past medical history of cervical cancer (stage IIIB) who presented with pain and swelling in her left upper arm over the preceding 2 months. MRI of the left upper arm showed a solid well-circumscribed mass measuring 7.0 × 2.8 × 2.5 cm, deep to the biceps. Biopsy of the mass revealed a metastatic squamous cell carcinoma that was p16-positive. PET scan showed that the lesion was the sole site of metastasis. She received local radiation with concurrent chemotherapy. Follow-up MRI 6 months after the completion of therapy showed resolution of the mass. She has remained disease-free for the last 24 months as evidenced by a PET/CT scan in May 2016. In this case report, we discuss the role of imaging and pathology in the diagnosis of a solitary metastatic lesion. This case also emphasizes the importance of a close follow-up which aids in early intervention, increasing overall survival.

scholarly journals Delayed Recovery from General Anaesthesia: A Post-operative Diagnostic Dilemma and Implications of ICU Management of Serotonin Toxicity. Case report

2015 ◽  
Vol 1 (4) ◽  
pp. 174-178
Author(s):  
Asha Naik ◽  
Cristobal Rincon-Aznar
Keyword(s):  
Methylene Blue ◽  
Differential Diagnosis ◽  
Case Report ◽  
Serotonin Syndrome ◽  
Unknown Etiology ◽  
Diagnostic Dilemma ◽  
Neurological Signs ◽  
Delayed Recovery ◽  
Icu Management ◽  
Serotonin Toxicity

Abstract We report a case of delayed recovery from general anesthesia following a routine parathyroidectomy. Our objectives are to describe the process of establishing a differential diagnosis and subsequent management of a patient presenting with atypical neurological signs from an unknown etiology and to increase awareness about the potential for serotonin syndrome and neurotoxicity due to known interactions between methylene blue and selective serotoninnoradrenaline re-uptake inhibitors. ICU management of Serotonin Toxicity is briefly described.

scholarly journals Case Report: A case report of Moyamoya disease in a 36 year old African American woman

F1000Research ◽  
2014 ◽  
Vol 3 ◽  
pp. 297 ◽  
Author(s):  
Rohit Kumar Gudepu ◽  
Mohtashim A. Qureshi ◽  
Ihtesham A. Qureshi ◽  
Lakshman Rao
Keyword(s):  
African American ◽  
Case Report ◽  
Blood Vessels ◽  
Medical Therapy ◽  
Moyamoya Disease ◽  
African American Woman ◽  
American Woman ◽  
African American Female ◽  
Ct Angiogram ◽  
The Brain

Moyamoya is a rare idiopathic progressive vaso-occlusive disease characterized by irreversible condition of main blood vessels to the brain as they enter into the skull. We present a case of 36 year old African American female presenting to the Out Patient Clinic with headache which were on and off for 4-6 months and did not relieve on routine medical therapy. It was associated with weakness on right side for last few days. The patient was investigated with CT Angiogram, diagnosed as Moyamoya disease and operated. She has been followed up for the last 5 years and the patient has not complained of any headaches or focal neurological symptoms.

scholarly journals Elevated lipoprotein(a)-associated accelerated thromboangiitis: A case report

2018 ◽  
Vol 5 (3) ◽  
pp. 17
Author(s):  
Jerad A.K. Harris ◽  
Mark Shane Gillispie ◽  
Claribel Solario ◽  
Melody L. Tran ◽  
Rogelio Pinon-Gutierrez ◽  
...  
Keyword(s):  
African American ◽  
Case Report ◽  
African American Woman ◽  
American Woman ◽  
Serum Levels ◽  
High Serum ◽  
Lipoprotein A

We describe a 47-year-old African American woman affected by a rapidly progressing thromboangiitis associated with high serum levels of lipoprotein(a) (Lp(a)).

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