Probable Diltiazem-Induced Acute Interstitial Nephritis

1998 ◽  
Vol 32 (6) ◽  
pp. 656-658 ◽  
Author(s):  
José A Abadín ◽  
José A Durán ◽  
José A Pérez de León
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Interstitial Nephritis ◽  
Healthcare Professionals ◽  
Maculopapular Rash ◽  
Acute Interstitial Nephritis ◽  
Test Results ◽  
The Third ◽  
Case Summary ◽  
Function Test

OBJECTIVE: To describe a case of acute interstitial nephritis (AIN) probably related to administration of diltiazem. CASE SUMMARY: A 53-year-old white man presented to the hospital experiencing abdominal pain radiating to both renal fossae, as well as dysuria. Diltiazem and atenolol had been prescribed to treat an episode of precordial pain associated with effort. An erythematous maculopapular rash developed approximately 2 hours after administration of a single dose of diltiazem, and acute renal failure, associated with elevated liver function test results, developed 6 days later. DISCUSSION: To the best of our knowledge, this is the third reported case of acute renal failure believed to be induced by diltiazem. In all cases, there was an obvious temporal relationship between administration of diltiazem and the onset of acute renal failure. Previous reports failed to discuss a probable pathogenic mechanism. AIN is the most likely etiology of acute renal failure in our patient. Favorable resolution with no relapse, the presence of the skin rash, and the liver sequelae suggest a common immunoallergic mechanism. CONCLUSIONS: Healthcare professionals should consider diltiazem-induced AIN in the differential diagnosis of a patient taking diltiazem who develops acute renal failure.

Tetracycline-Induced Acute Interstitial Nephritis as a Cause of Acute Renal Failure

Nephron ◽  
1999 ◽  
Vol 81 (1) ◽  
pp. 72-75 ◽  
Author(s):  
A. Bihorac ◽  
Ç. Özener ◽  
E. Akoglu ◽  
S. Kullu
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Interstitial Nephritis ◽  
Acute Interstitial Nephritis

Acute Renal Failure in Patients with Drug-Induced Acute Interstitial Nephritis

Renal Failure ◽  
1993 ◽  
Vol 15 (1) ◽  
pp. 69-72 ◽  
Author(s):  
Mira Koselj ◽  
Rado Kveder ◽  
Andrej F. Bren ◽  
Tomaz Rott
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Interstitial Nephritis ◽  
Acute Interstitial Nephritis ◽  
Drug Induced

scholarly journals Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy

2021 ◽  
Vol 2021 ◽  
pp. 1-4 ◽  
Author(s):  
Antonio Faieta ◽  
Tavis Dancik
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Interstitial Nephritis ◽  
Acute Interstitial Nephritis ◽  
Term Treatment ◽  
Steroid Dependent ◽  
Long Term Treatment ◽  
Grade 3

A 65-year-old male patient with metastatic CCRCC developed steroid-dependent, grade 3 AIN secondary to nivolumab weeks after its initiation that resulted in 3 hospitalizations with acute renal failure. The patient was started on MM and his AIN was successfully controlled after a 2-year period of follow-up. Refractory renal AIN resulting from PD-1 inhibitor use is rare, and its successful treatment with mofetil mycophenolate with a 2-year follow-up in a patient with metastatic CCRCC has not been reported. This case is important because not only was his renal irAEs controlled but also long-term treatment with MM did not result in progression of metastatic disease.

scholarly journals Asian wasp envenomation and acute renal failure: a report of two cases

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Rabindra Das ◽  
Keka Mukherjee
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Hypersensitivity Reaction ◽  
Interstitial Nephritis ◽  
Hepatic Dysfunction ◽  
Acute Interstitial Nephritis ◽  
Unusual Complication ◽  
Tubular Necrosis ◽  
Wasp Stings ◽  
Vespa Affinis

Acute renal failure is an unusual complication of wasp stings. We report two cases of renal failure after multiple wasp stings (Vespa affinis). Both patients had evidence of intravascular haemolysis, hepatic dysfunction, oligo-anuria and azotaemia and required dialysis. The first patient had severe hemolysis, rhabdomyolysis, pigment and venom nephropathy and died on the 8th day in hospital. The second patient, who recovered completely in 3 weeks time with steroid and antihistaminic therapy, had interstitial nephritis. Although acute renal failure after wasp stings is typically caused by acute tubular necrosis (ATN) in the setting of haemolysis or rhabdomyolysis, in some patients, acute renal failure may result from a direct nephrotoxic effect or acute interstitial nephritis from a hypersensitivity reaction.

Suspected Nafcillin-Induced Interstitial Nephritis

1993 ◽  
Vol 27 (2) ◽  
pp. 170-173 ◽  
Author(s):  
Sudip Roy Guharoy ◽  
Sheila Kar ◽  
James Mcgalliard
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Case Report ◽  
Literature Review ◽  
Renal Impairment ◽  
Interstitial Nephritis ◽  
Acute Interstitial Nephritis ◽  
Staphylococcal Pneumonia ◽  
Allergic Manifestations

Objective To present a case of nafcillin-induced interstitial nephritis. Methodology Case report and literature review. Setting Hospital. Results Three days following initiation of nafcillin therapy for staphylococcal pneumonia, an 80-year-old woman developed allergic manifestations and progressive renal impairment suggestive of acute allergic interstitial nephritis. These manifestations were completely reversed within 96 hours of cessation of nafcillin therapy. Conclusions In the clinical setting of acute renal failure in a patient on nafcillin therapy, acute interstitial nephritis should be considered. Prompt cessation of nafcillin therapy has generally been associated with reversal of symptoms and an improvement in renal function.

scholarly journals A CASE OF ACUTE RENAL FAILURE DUE TO ACUTE INTERSTITIAL NEPHRITIS

1976 ◽  
Vol 67 (1) ◽  
pp. 40-46
Author(s):  
Hisao Takayasu ◽  
Kiyoki Okada ◽  
Akira Ueno ◽  
Osamu Tsukada
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Interstitial Nephritis ◽  
Acute Interstitial Nephritis
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