Linear Immunoglobulin a Bullous Dermatosis Induced by Gemcitabine

2001 ◽  
Vol 35 (7-8) ◽  
pp. 891-893 ◽  
Author(s):  
Jesús del Pozo ◽  
Walter Martínez ◽  
María T Yebra-Pimentel ◽  
Manuel Almagro ◽  
Carmen Peña-Penabad ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Topical Steroid ◽  
Direct Immunofluorescence ◽  
Cutaneous Lesions ◽  
Drug Induced ◽  
Cutaneous Eruption ◽  
First Case ◽  
Bullous Dermatosis ◽  
Relationship Of ◽  
The Relationship

OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine. CASE SUMMARY: A 59-year-old man was diagnosed with squamous-cell carcinoma of the lung in T4N2M0 stage and treated with cisplatin, vinorelbine, and gemcitabine. Twenty-four hours after the administration of gemcitabine, a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs. Histopathologic examination and direct immunofluorescence test were consistent with IgA bullous dermatosis. Cutaneous lesions resolved two weeks after the drug was withdrawn and topical steroid treatment was instituted. DISCUSSION: Drug-induced LABD is a variant of classic or idiopathic LABD. Vancomycin is the most frequently implicated drug, but other agents have been reported to cause LABD. According to the Naranjo probability scale, the relationship of gemcitabine treatment with cutaneous eruption in our patient is possible. CONCLUSIONS: We report the first case of gemcitabine-induced LABD. Clinicians should monitor patients receiving this drug for signs of LABD.

scholarly journals Lichen Planus Pemphigoides Induced by Enalapril: A Case Report and a Review of Literature

2017 ◽  
Vol 9 (3) ◽  
pp. 217-224 ◽  
Author(s):  
Woranit Onprasert ◽  
Kumutnart Chanprapaph
Keyword(s):  
Lichen Planus ◽  
Early Recognition ◽  
Case Reports ◽  
Direct Immunofluorescence ◽  
Drug Induced ◽  
First Case ◽  
Bullous Dermatosis ◽  
Culprit Drug ◽  
History Of ◽  
Hands And Feet

Lichen planus pemphigoides (LPP) is a rare autoimmune bullous dermatosis. The clinical presentation of LPP may mimic bullous pemphigoid making the diagnosis difficult. A thorough clinical, histopathological, and immunological evaluation is essential for the diagnosis of LPP. The etiology is largely idiopathic; however, there are several case reports of drug-induced LPP. We report an 81-year-old Thai woman with underlying hypertension and type 2 diabetes mellitus who presented with a 4-week history of multiple tense bullae initially on the hands and feet that subsequently expanded to the trunk and face. Enalapril was commenced to control hypertension. The histopathology and direct immunofluorescence were compatible with LPP. Circulating anti-basement antibodies BP180 was also positive. The patient was treated with topical corticosteroid with a modest effect. Enalapril was discontinued and complete resolution of LPP occurred within 12 weeks. There was no recurrence after a 1-year follow-up period. To the best of our knowledge, we present the first case of enalapril-induced LPP. Early recognition and prompt discontinuation of the culprit drug allow resolution of the disease. Medication given for LPP alone, without cessation of the offending drug, may not change the course of this condition.

scholarly journals Drug‐induced linear immunoglobulin A bullous dermatosis: A French retrospective pharmacovigilance study of 69 cases

2019 ◽  
Vol 85 (3) ◽  
pp. 570-579 ◽  
Author(s):  
Bethsabée Garel ◽  
Saskia Ingen‐Housz‐Oro ◽  
Daniele Afriat ◽  
Catherine Prost‐Squarcioni ◽  
Florence Tétart ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Drug Induced ◽  
Bullous Dermatosis

Factors Contributing to Intra-Individual Variation of Serum Constituents: 5. Short-Term Day-to-Day and Within-Hour Variation of Serum Constituents in Healthy Subjects

1974 ◽  
Vol 20 (12) ◽  
pp. 1520-1527 ◽  
Author(s):  
Per Winkel ◽  
Bernard E Statland ◽  
Henning Bokelund
Keyword(s):  
Total Lipids ◽  
Short Term ◽  
Serum Samples ◽  
Interaction Terms ◽  
Anova Model ◽  
First Case ◽  
Main Effect ◽  
Relationship Of ◽  
The Relationship ◽  
Analytical Variation

Abstract We evaluated the variations in some serum constituents in a group of healthy young men for two selected time intervals: short-term day-to-day changes and within-hour changes. In the first case, we used a two-way ANOVA model to compute the main-day effect and the subject-day interaction terms, which were combined to yield the total day-to-day variation. A main-day effect was seen to be statistically significant only for acid phosphatase, while all of the 18 serum constituents except for sodium, calcium, and albumin demonstrated a statistically significant subject-day interaction. For the within-hour biologic variation, a three-way ANOVA model was used to analyze results of duplicate serum samples drawn at 1100 h and 1130 h on two different days. Although a significant main effect of hour was found only for total lipids and alkaline phosphatase, pooling the main effect of hour, subject-hour interaction, and subject-day-hour interaction terms resulted in a chemically significant variation for potassium, total protein, albumin, iron, total lipids, cholesterol, and bilirubin. The relationship of these biological fluctuations is compared to the expected analytical variation in all cases.

Expressions of CD3 and CD4 T Cells in Peripheral Blood of Patients with Immunoglobulin A Nephropathy and Their Clinical Significance

2019 ◽  
Vol 9 (6) ◽  
pp. 865-869
Author(s):  
Xuecheng Zhang ◽  
Ning Su ◽  
Dong Chen
Keyword(s):  
T Cells ◽  
Peripheral Blood ◽  
Cd4 T Cells ◽  
Quantitative Polymerase Chain Reaction ◽  
Immunoglobulin A ◽  
Immunoglobulin A Nephropathy ◽  
Abnormal Immune Response ◽  
History Of ◽  
Relationship Of ◽  
The Relationship

Immunoglobulin A nephropathy (IgAN) is a primary glomerulonephritis characterized by abnormal immune response-mediated deposition of polymeric IgA (pIgA) in mesangium. As a type of important immune cells, the relationship of CD3 or CD4 with the pathogenesis of IgAN remains poorly understood. In this study, 38 patients with IgAN, 7 patients with idiopathic membranous nephropathy (MN) and 46 healthy adults without history of kidney disease were enrolled. Peripheral blood was collected for further evaluation of the expressions of CD3 and CD4 and IgA by flow cytometry, quantitative polymerase chain reaction (qPCR) and Western blot. Meanwhile, the expression of IgA was detected by ELISA. The result showed that expression of CD3 T cells was down-regulated in patients with IgAN, while amounts of CD4 T cells and IgA level were significantly increased compared to normal control (P < 0.05). However, no signficant changes in CD3, CD4 T cells were found in patients with MN. Our study demonstrates that CD3 and CD4 T cells as well as IgA are involved in the pathogenesis of IgAN and these targets might be beneficial for the treatment of IgAN.

scholarly journals Sarcoidosis Developing During Secukinumab Therapy: Case Report

2017 ◽  
Vol 1 (2) ◽  
pp. 95
Author(s):  
Timothy Nyckowski ◽  
Roger Ceilley ◽  
Joshua Wilson
Keyword(s):  
Case Report ◽  
Psoriatic Arthritis ◽  
Side Effect ◽  
Pulmonary Involvement ◽  
Unknown Etiology ◽  
Systemic Involvement ◽  
First Case ◽  
Relationship Of ◽  
The Relationship

Introduction: Sarcoidosis is a systemic granulomatous inflammatory disease with an unknown etiology and complex pathogenesis. Existing literature supports the relationship of new-onset sarcoidosis with the use of a several biologic agents. Since the skin is the second most commonly involved organ in sarcoidosis and often precedes systemic involvement, dermatologists must be able to recognize its non-specific clinical presentation.Case Report: We present a 45 year old female with psoriatic arthritis who developed biopsy proven cutaneous sarcoidal granulomas with pulmonary involvement shortly after initiating secukinumab for treatment of psoriatic arthritis. Despite discontinuation of secukinumab, the sarcoidosis has persisted.Discussion: This is the first case report of secukinumab, or any IL-17 inhibitor related sarcoidosis that we are aware of in the literature. Dermatologists should be aware of this as a possible side effect of secukinumab use. As the research on the role of IL-17 in the pathogenesis of sarcoidosis continues to develop, the implications of this side effect of IL-17 inhibition may have important future implications.

scholarly journals Identity, Equality, Nameability and Completeness

2017 ◽  
Vol 46 (3/4) ◽  
Author(s):  
María Manzano ◽  
Manuel Crescencio Moreno
Keyword(s):  
Binary Relation ◽  
Order Logic ◽  
The Other ◽  
Higher Order Logic ◽  
First Case ◽  
General Semantics ◽  
Relevant Role ◽  
Definition Of ◽  
Relationship Of ◽  
The Relationship

This article is an extended promenade strolling along the winding roads of identity, equality, nameability and completeness, looking for places where they converge. We have distinguished between identity and equality; the first is a binary relation between objects while the second is a symbolic relation between terms. Owing to the central role the notion of identity plays in logic, you can be interested either in how to define it using other logical concepts or in the opposite scheme. In the first case, one investigates what kind of logic is required. In the second case, one is interested in the definition of the other logical concepts (connectives and quantifiers) in terms of the identity relation, using also abstraction. The present paper investigates whether identity can be introduced by definition arriving to the conclusion that only in full higher-order logic a reliable definition of identity is possible. However, the definition needs the standard semantics and we know that with this semantics completeness is lost. We have also studied the relationship of equality with comprehension and extensionality and pointed out the relevant role played by these two axioms in Henkin’s completeness method. We finish our paper with a section devoted to general semantics, where the role played by the nameable hierarchy of types is the key in Henkin’s completeness method.

Two Cases of Epithelioid Angiosarcoma Involving the Thyroid and a Brief Review of Non-Alpine Epithelioid Angiosarcoma of the Thyroid

2003 ◽  
Vol 127 (2) ◽  
pp. e70-e73 ◽  
Author(s):  
Seng Geok Nicholas Goh ◽  
Khoon Leong Chuah ◽  
Hood Keng Christopher Goh ◽  
Yun Yin Cosmas Chen
Keyword(s):  
Thyroid Disease ◽  
Positive Staining ◽  
Epithelioid Cells ◽  
Epithelioid Angiosarcoma ◽  
Old Chinese ◽  
First Case ◽  
History Of ◽  
Vascular Structures ◽  
Relationship Of ◽  
The Relationship

Abstract Epithelioid angiosarcoma involving the thyroid is a rare entity, more often described in the Alpine region. Two cases of epithelioid angiosarcoma that affected the thyroid in patients from a non-Alpine location were diagnosed during a 10-year period in our department. The first case occurred in an 89-year-old Chinese man with a history of longstanding goiter, whereas the second case involved a 74-year-old Chinese man with a history of angiosarcoma of the scalp. On histologic examination, both thyroid tumors were composed of plump epithelioid cells with vesicular chromatin and prominent nucleoli, forming vascular structures and solid sheets. Positive staining for CD31 and factor VIII–related antigen confirmed endothelial differentiation in both cases. Both patients died within 5 months following the diagnosis of thyroid disease. The relationship of the scalp angiosarcoma and thyroid disease of the second patient is unclear. A brief review of non-Alpine primary thyroid epithelioid angiosarcoma is presented.

Drug-Induced Linear Immunoglobulin-A Bullous Dermatosis

1998 ◽  
Vol 16 (3) ◽  
pp. 389-391 ◽  
Author(s):  
Michael Camilleri ◽  
Joseph L. Pace
Keyword(s):  
Immunoglobulin A ◽  
Drug Induced ◽  
Bullous Dermatosis
Sign in / Sign up

Export Citation Format

Share Document