scholarly journals Antioxidant Effects of Mixed Doses of Vitamins B12 and E on Male Wistar Albino Rats Infected with Trypanosoma Brucei Brucei

2020 ◽  
Vol 8 (2) ◽  
pp. 7-13
Author(s):  
Edoga C. O. ◽  
Ejo J. E. ◽  
Anukwuorji C. A. ◽  
Ani C. E. ◽  
Izundu M. I.
Keyword(s):  
Trypanosoma Brucei ◽  
Albino Rats ◽  
Trypanosoma Brucei Brucei ◽  
Wistar Albino Rats ◽  
Antioxidant Effects

Effects of Trypanosoma brucei brucei infection and diminazene aceturate administration on the blood pressure, heart rate, and temperature of Wistar albino rats

2018 ◽  
Vol 29 (3) ◽  
pp. 265-269
Author(s):  
Olushola Emmanuel Adeleye ◽  
Jude Makinde Ale ◽  
Emmanuella Olubanke Amope Sogebi ◽  
Ladoke A. Durotoye ◽  
Adenike Iyabo Adeleye ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Trypanosoma Brucei ◽  
Treated Group ◽  
Control Group ◽  
Albino Rats ◽  
Trypanosoma Brucei Brucei ◽  
Blood Pressure Monitor ◽  
Diminazene Aceturate ◽  
Wistar Albino Rats

Abstract Background: This study was carried out to determine the blood pressure changes in experimentally Trypanosoma brucei brucei-infected Wistar albino rats and diminazene aceturate-treated rats. Methods: Twenty-four rats were purchased and divided into four groups consisting of six rats each. Control group (CON) received 0.5 mL of distilled water, i.m., infected but not treated group (INF) received 2×106 trypanosome/mL i.m., infected but diminazene aceturate-treated group (INFDIM) received 2×106 trypanosome/mL, 3.5 mg/kg, i.m.) and non-infected but diminazene aceturate-treated group (DIM) received 3.5 mg/kg, i.m. and served as negative control. The blood pressures were measured using a CODA 2® non-invasive blood pressure monitor (Kent Scientific, USA). The results were compiled and statistical analysis was done with significance set at p≥0.05. Results: The values of the blood pressure readings of the Trypanosoma-infected INF (137.0±2.0 mmHg) and diminazene-treated rats INFDIM (125.0±7.5 mmHg) when compared to the control group (168.0±3.0 mmHg) were significantly lower (p≤0.05) at the end of day 7. The heart rate was also significantly reduced in the INF (403.5±1.5 beats/min) and DIM (445.0±24 beats/min) groups of rats when compared with the control group (613.0±2.0 beats/min) at the end of day 8. Conclusion: The findings indicate the significant reduction in blood pressure and heart rates during Trypanosoma brucei brucei infection and with diminazene aceturate administration. Hence, caution should be exercised when treating trypanosome-infected patients with diminazene aceturate.

scholarly journals Correction to: Impaired epididymal function in Trypanosoma brucei brucei and Trypanosoma congolense infected and treated albino rats

2019 ◽  
Vol 28 (5) ◽  
pp. 1535-1535
Author(s):  
M. I. Okpala ◽  
I. O. Ezeh ◽  
C. F. Obi ◽  
I. S. Ochiogu ◽  
R. I. Obidike ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Trypanosoma Congolense ◽  
Albino Rats ◽  
Trypanosoma Brucei Brucei

Impaired epididymal function of albino rats infected and treated with Trypanosoma brucei brucei and Trypanosoma congolense

2019 ◽  
Vol 28 (5) ◽  
pp. 1415-1420
Author(s):  
M. I. Okpala ◽  
I. O. Ezeh ◽  
C. F. Obi ◽  
I. S. Ochiogu ◽  
R. I. Obidike ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Trypanosoma Congolense ◽  
Albino Rats ◽  
Trypanosoma Brucei Brucei

Efficacy of combined therapy of Diminaveto® and Intromidium® in albino rats experimentally infected with Trypanosoma brucei brucei

2021 ◽  
Author(s):  
Michael Ikenna Okpala ◽  
Chukwunonso Francis Obi ◽  
Ikenna Onyema Ezeh ◽  
Lotanna Gilbert Nwobi ◽  
Terry Adaeze Nzeakor ◽  
...  
Keyword(s):  
Trypanosoma Brucei ◽  
Combined Therapy ◽  
Albino Rats ◽  
Trypanosoma Brucei Brucei

Azithromycin and Diminazene Aceturate Combination Therapy in Experimental Multidrug-resistant Trypanosoma brucei brucei Infection in Albino Rats

2020 ◽  
Vol 282 ◽  
pp. 109138
Author(s):  
Chukwunonso Francis Obi ◽  
Ikenna Onyema Ezeh ◽  
Michael Ikenna Okpala ◽  
Idika Kalu Idika ◽  
Nnamdi Mbe ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Trypanosoma Brucei ◽  
Multidrug Resistant ◽  
Albino Rats ◽  
Trypanosoma Brucei Brucei ◽  
Diminazene Aceturate
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