scholarly journals Evaluation of Inotropic Activity of Fluorobenzene Derivative Using an Isolated Rat Heart Model

2018 ◽  
Vol 6 (1) ◽  
pp. 1-11
Author(s):  
Figueroa-Valverde Lauro ◽  
Hau-Heredia Lenin ◽  
García-Cervera Elodia ◽  
López-Ramos Maria ◽  
Díaz-Cedillo Francisco ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Heart Model ◽  
Inotropic Activity ◽  
Isolated Rat

Positive inotropic activity induced by a dehydroisoandrosterone derivative in isolated rat heart model

2013 ◽  
Vol 36 (10) ◽  
pp. 1270-1278 ◽  
Author(s):  
L. Figueroa-Valverde ◽  
F. Díaz-Cedillo ◽  
E. García-Cervera ◽  
E. Pool Gómez ◽  
M. López-Ramos ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Heart Model ◽  
Inotropic Activity ◽  
Isolated Rat

scholarly journals Evaluation of Positive Inotropic Activity Induced bya Danazol Derivative in Isolated Rat Heart Model

2013 ◽  
Vol 04 (04) ◽  
pp. 406-415
Author(s):  
L. Figueroa-Valverde ◽  
F. Díaz-Cedillo ◽  
E. García-Cervera ◽  
E. Pool Gómez ◽  
M. López-Ramos ◽  
...  
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Heart Model ◽  
Inotropic Activity ◽  
Isolated Rat

Dobutamine responsiveness, PET mismatch, and lack of necrosis in low-flow ischemia: is this hibernation in the isolated rat heart?

2003 ◽  
Vol 285 (1) ◽  
pp. H316-H324 ◽  
Author(s):  
Richard Southworth ◽  
Pamela B. Garlick
Keyword(s):  
Rat Heart ◽  
Recovery Of Function ◽  
Electron Microscopic Examination ◽  
Left Ventricular ◽  
Isolated Rat Heart ◽  
Low Flow ◽  
Hibernating Myocardium ◽  
Heart Model ◽  
Electron Microscopic ◽  
Isolated Rat

The clinical hallmarks of hibernating myocardium include hypocontractility while retaining an inotropic reserve (using dobutamine echocardiography), having normal or increased [18F]fluoro-2-deoxyglucose-6-phosphate (18FDG6P) accumulation associated with decreased coronary flow [flow-metabolism mismatch by positron emission tomography (PET)], and recovering completely postrevascularization. In this study, we investigated an isolated rat heart model of hibernation using experimental equivalents of these clinical techniques. Rat hearts ( n = 5 hearts/group) were perfused with Krebs-Henseleit buffer for 40 min at 100% flow and 3 h at 10% flow and reperfused at 100% flow for 30 min (paced at 300 beats/min throughout). Left ventricular developed pressure fell to 30 ± 8% during 10% flow and recovered to 90 ± 7% after reperfusion. In an additional group, this recovery of function was found to be preserved over 2 h of reperfusion. Electron microscopic examination of hearts fixed at the end of the hibernation period demonstrated a lack of ischemic injury and an accumulation of glycogen granules, a phenomenon observed clinically. In a further group, hearts were challenged with dobutamine during the low-flow period. Hearts demonstrated an inotropic reserve at the expense of increased lactate leakage, with no appreciable creatine kinase release. PET studies used the same basic protocol in both dual- and globally perfused hearts (with 250MBq18FDG in Krebs buffer ± 0.4 mmol/l oleate). PET data showed flow-metabolism “mismatch;” whether regional or global,18FDG6P accumulation in ischemic tissue was the same as (glucose only) or significantly higher than (glucose + oleate) control tissue (0.023 ± 0.002 vs. 0.011 ± 0.002 normalized counts · s-1· g-1· min-1, P < 0.05) despite receiving 10% of the flow. This isolated rat heart model of acute hibernation exhibits many of the same characteristics demonstrated clinically in hibernating myocardium.

Accelerated BMIPP uptake immediately after reperfused ischemia in the isolated rat heart model

2011 ◽  
Vol 25 (8) ◽  
pp. 560-565
Author(s):  
Kenji Fukushima ◽  
Mitsuru Momose ◽  
Chisato Kondo ◽  
Nobuhisa Hagiwara ◽  
Shuji Sakai
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Heart Model ◽  
Bmipp Uptake ◽  
Isolated Rat

ATP-loaded immunoliposomes specific for cardiac myosin provide improved protection of the mechanical functions of myocardium from global ischemia in an isolated rat heart model

2006 ◽  
Vol 14 (5) ◽  
pp. 273-280 ◽  
Author(s):  
Daya D. Verma ◽  
Tatyana S. Levchenko ◽  
Eugene A. Bernstein ◽  
Dmitriy Mongayt ◽  
Vladimir P. Torchilin
Keyword(s):  
Rat Heart ◽  
Isolated Rat Heart ◽  
Global Ischemia ◽  
Cardiac Myosin ◽  
Heart Model ◽  
Isolated Rat

scholarly journals Ozone reduces reperfusion injury in an isolated rat heart model

2003 ◽  
Vol 41 (6) ◽  
pp. 331
Author(s):  
Ofer Merin ◽  
Eyal Atias ◽  
Ari Zimran ◽  
Debbie Elstein ◽  
Gerhard Wasser ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Heart Model ◽  
Isolated Rat

Ozone Administration Reduces Reperfusion Injury in an Isolated Rat Heart Model

2007 ◽  
Vol 22 (4) ◽  
pp. 339-342 ◽  
Author(s):  
Ofer Merin ◽  
Eyal Attias ◽  
Deborah Elstein ◽  
Herzl Schwalb ◽  
Dani Bitran ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Rat Heart ◽  
Isolated Rat Heart ◽  
Heart Model ◽  
Isolated Rat

scholarly journals Gradual Clamping Reduced Ischemia-Reperfusion Injury in an Isolated Rat Heart Model

2016 ◽  
Vol 06 (06) ◽  
pp. 79-86
Author(s):  
Hongbin Feng ◽  
Hongli Wang ◽  
Yang Zhao ◽  
Zhinan Zheng ◽  
Sanqing Jin
Keyword(s):  
Reperfusion Injury ◽  
Rat Heart ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Isolated Rat Heart ◽  
Heart Model ◽  
Isolated Rat
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