Capture and Isotopic Exchange Method for Water and Hydrogen Isotopes on Zeolite Catalysts up to Technical Scale for Pre-Study of Processing Highly Tritiated Water

2015 ◽  
Vol 67 (3) ◽  
pp. 483-486 ◽  
Author(s):  
Robert Michling ◽  
Adalbert Braun ◽  
Ion Cristescu ◽  
Helmut Dittrich ◽  
Manfred Glugla ◽  
...  
Keyword(s):  
Isotopic Exchange ◽  
Tritiated Water ◽  
Hydrogen Isotopes ◽  
Zeolite Catalysts ◽  
Exchange Method

Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

2019 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

scholarly journals ELECTRO-OSMOTIC FRACTIONATION OF HYDROGEN ISOTOPES IN ELECTROLYTIC SOLUTIONS USING COMPOSITE PROTON-PERMEABLE MEMBRANES

2021 ◽  
pp. 11-16
Author(s):  
O. Pushkar'ov ◽  
A. Zubko ◽  
I. Sevruk ◽  
V. Dolin
Keyword(s):  
Hydrogen Bonds ◽  
Proton Conductivity ◽  
Tritiated Water ◽  
High Mobility ◽  
Hydrogen Isotopes ◽  
Water Molecules ◽  
Proton Conducting ◽  
Partial Dissociation ◽  
Surface Modified ◽  
Conducting Membranes

Based on the analysis of the features of electroosmotic processes that are implemented in proton-conducting membranes, the possibility of fractioning hydrogen isotopes in electrolytes formed using tritiated water (HTO) is estimated. The interaction of the solution with the membranes in their channels leads to polarization and partial dissociation of the electrolyte molecules. In water molecules, when protium is replaced by a heavy isotope of hydrogen, the energy of breaking of hydrogen bonds increases and the process of their dissociation proceeds predominantly according to the scheme: HTO ↔ H+ + TO—. A part of the released protons can join water molecules to form the H3O+ ion. H3O+ and TO— ions are more mobile than other singly charged ions. The main characteristic that determines the suitability of electroosmotic membranes to the fractionation of hydrogen isotopes is proton conductivity. The released protons have anomalously high mobility due to their small size, tunnel and relay movement through hydrogen bonds between adjacent polar groups in the channels of the proton-conducting membranes. To ensure high proton conductivity in the pores and channels of the membranes, modifying substances are fixed, which contain the groups: –ОН- , –NH2, –NH, –SH, –COOH, –SO3H, acid salts and oxides, containing surface proton-conducting groups. To create proton-conducting membranes, it is possible to use surface-modified β-alumina (β-Al2O3(H3O+)) and protonated (H3O+) montmorillonite with ionic conductivity (5х103 – 4х104 Ohm х cm–1). The most effective are surface modifiers with negatively charged sulfonic groups. The imposition of an external electric field leads to the movement of ions in the electrolyte, which leads to a redistribution of the isotope ratio in the near-anode and cathode spaces.

Solubility, Diffusivity, and Isotopic Exchange Rate of Hydrogen Isotopes in Li-Pb

2008 ◽  
Vol 54 (1) ◽  
pp. 131-134 ◽  
Author(s):  
Y. Maeda ◽  
Y. Edao ◽  
S. Yamaguchi ◽  
S. Fukada
Keyword(s):  
Exchange Rate ◽  
Isotopic Exchange ◽  
Hydrogen Isotopes

Insights into the catalytic activity of Ru/NaY catalysts for efficient H2 production through aqueous phase reforming

2020 ◽  
Vol 4 (2) ◽  
pp. 678-690 ◽  
Author(s):  
Pranjal Gogoi ◽  
Atul S. Nagpure ◽  
Prabu Kandasamy ◽  
C. V. V. Satyanarayana ◽  
Thirumalaiswamy Raja
Keyword(s):  
Catalytic Activity ◽  
Ion Exchange ◽  
Aqueous Phase ◽  
H2 Production ◽  
Zeolite Catalysts ◽  
Nay Zeolite ◽  
Ruthenium Nanoparticles ◽  
Exchange Method ◽  
Aqueous Phase Reforming ◽  
Ion Exchange Method

Ruthenium nanoparticles supported on NaY zeolite catalysts were synthesized by a simple ion exchange method.

Peculiarities of the isotopic exchange of the hydrogen of the hydroxyl groups of metal-zeolite catalysts

1975 ◽  
Vol 24 (12) ◽  
pp. 2556-2558
Author(s):  
Kh. M. Minachev ◽  
R. V. Dmitriev ◽  
K. -G. Steinberg ◽  
G. Bremer ◽  
A. N. Detyuk
Keyword(s):  
Isotopic Exchange ◽  
Zeolite Catalysts ◽  
Hydroxyl Groups

The solubility and isotopic exchange equilibrium for hydrogen isotopes in lithium

1979 ◽  
Vol 41 (7) ◽  
pp. 1001-1009 ◽  
Author(s):  
F.J. Smith ◽  
J.F. Land ◽  
G.M. Begun ◽  
A.M. La Gamma de Batistoni
Keyword(s):  
Isotopic Exchange ◽  
Hydrogen Isotopes ◽  
Exchange Equilibrium

Highly Tritiated Water Processing by Isotopic Exchange

2015 ◽  
Vol 67 (3) ◽  
pp. 563-566 ◽  
Author(s):  
W. M. Shu ◽  
I. Cristescu ◽  
R. Michling ◽  
D. Demange ◽  
R. S. Willms ◽  
...  
Keyword(s):  
Isotopic Exchange ◽  
Tritiated Water

scholarly journals [18F]SuFEx Click Chemistry Enabled Ultrafast Late-stage Radiosynthesis

2020 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

scholarly journals A New Type of Radiometric Analysis—Non-equilibrium Isotopic Exchange Method

RADIOISOTOPES ◽  
1969 ◽  
Vol 18 (6) ◽  
pp. 224-226 ◽  
Author(s):  
Nagao IKEDA ◽  
Kan KIMURA ◽  
Yasuko TAKAHASHI ◽  
Yoshiko FUJIKI
Keyword(s):  
Isotopic Exchange ◽  
Exchange Method ◽  
Radiometric Analysis ◽  
New Type ◽  
Non Equilibrium
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