Development of a Cryogenic Target Delivery System for HiPER

2009 ◽  
Vol 56 (1) ◽  
pp. 405-408
Author(s):  
Paul J. Perin ◽  
J. Manuel Perlado ◽  
Martin Tolley ◽  
Keyword(s):  
Delivery System ◽  
Target Delivery ◽  
Cryogenic Target

scholarly journals Conceptual design report for the University of Rochester cryogenic target delivery system

1993 ◽  
Author(s):  
R.L. Fagaly ◽  
N.B. Alexander ◽  
R.F. Bourque ◽  
C.F. Dahms ◽  
J.R. Lindgren ◽  
...  
Keyword(s):  
Conceptual Design ◽  
Delivery System ◽  
Target Delivery ◽  
Cryogenic Target ◽  
The University ◽  
Conceptual Design Report

Conceptual design for the OMEGA Upgrade Cryogenic Target Delivery System

2002 ◽  
Author(s):  
R.L. Fagaly ◽  
N.B. Alexander ◽  
R.A. Mangano ◽  
R.F. Bourque ◽  
D.N. Bittner ◽  
...  
Keyword(s):  
Conceptual Design ◽  
Delivery System ◽  
Target Delivery ◽  
Cryogenic Target

scholarly journals Conceptual design report for the University of Rochester cryogenic target delivery system

1993 ◽  
Author(s):  
R.L. Fagaly ◽  
N.B. Alexander ◽  
R.F. Bourque ◽  
C.F. Dahms ◽  
J.R. Lindgren ◽  
...  
Keyword(s):  
Conceptual Design ◽  
Delivery System ◽  
Target Delivery ◽  
Cryogenic Target ◽  
The University ◽  
Conceptual Design Report

Development of target delivery system based on actinomycin class drugs and recombinant alpha-fetoprotein

2017 ◽  
Vol 473 (1) ◽  
pp. 148-150 ◽  
Author(s):  
E. D. Nikolskaya ◽  
O. A. Zhunina ◽  
N. G. Yabbarov ◽  
V. I. Shvets ◽  
B. I. Krugliy ◽  
...  
Keyword(s):  
Delivery System ◽  
Alpha Fetoprotein ◽  
Target Delivery

scholarly journals Target delivery of MYCN siRNA by folate-nanoliposomes delivery system in a metastatic neuroblastoma model

2013 ◽  
Vol 13 (1) ◽  
pp. 65 ◽  
Author(s):  
Qiqi Zhu ◽  
Chen Feng ◽  
Weiwei Liao ◽  
Yan Zhang ◽  
Suoqin Tang
Keyword(s):  
Delivery System ◽  
Target Delivery

scholarly journals Rationale and Application of PEGylated Lipid-Based System for Advanced Target Delivery of siRNA

2021 ◽  
Vol 11 ◽  
Author(s):  
Xuemei Ge ◽  
Lijuan Chen ◽  
Bo Zhao ◽  
Weien Yuan
Keyword(s):  
Delivery System ◽  
High Efficiency ◽  
Sirna Delivery ◽  
High Specificity ◽  
Life Time ◽  
Delivery Systems ◽  
Target Delivery ◽  
Rnai Technology ◽  
Targeting Delivery

RNA interference (RNAi) technology has become a powerful tool in application of unraveling the mechanism of disease and may hold the potential to be developed for clinical uses. Small interfering RNA (siRNA) can bind to target mRNA with high specificity and efficacy and thus inhibit the expression of related protein for the purpose of treatment of diseases. The major challenge for RNAi application is how to improve its stability and bioactivity and therefore deliver therapeutic agents to the target sites with high efficiency and accuracy. PEGylated lipid-based delivery system has been widely used for development of various medicines due to its long circulating half-life time, low toxicity, biocompatibility, and easiness to be scaled up. The PEGylated lipid-based delivery system may also provide platform for targeting delivery of nucleic acids, and some of the research works have moved to the phases for clinical trials. In this review, we introduced the mechanism, major challenges, and strategies to overcome technical barriers of PEGylated lipid-based delivery systems for advanced target delivery of siRNA in vivo. We also summarized recent advance of PEGylated lipid-based siRNA delivery systems and included some successful research works in this field.

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